Review
Ecology
Julia Joanna Pawluk, Magdalena Zagalska-Neubauer
Summary: The sex ratio of sexually reproducing animal species is usually close to 1:1 and can be influenced by both parents. This review focuses on summarizing the knowledge of male control in sex allocation, particularly the mechanisms of adjustment at different stages. While maternal effects are well studied, the paternal effects on sex ratio remain elusive.
Article
Geriatrics & Gerontology
Maryam Farahmand, Maryam Mousavi, Amir Abbas Momenan, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study investigated the association between age at menarche and the incidence of arterial hypertension. The findings suggest that late menarche may be a risk factor for arterial hypertension and should be considered in cardiovascular risk assessment programs.
Article
Marine & Freshwater Biology
Guirandy Noemie, Gagnaire Beatrice, Camilleri Virginie, Cavalie Isabelle, Pierron Fabien, Gonzalez Patrice, Simon Olivier
Summary: In this study, the effects of radiation exposure on zebrafish across multiple generations were examined. The results showed that radiation impacted the reproductive capacity, larval survival rate, and sex ratio of the fish. These findings suggest that radiation can alter population dynamics and have worsening effects over generations. This highlights the importance of conducting multigenerational studies for assessing the ecological risk of radiation in fish.
AQUATIC TOXICOLOGY
(2022)
Article
Ecology
Cora E. Anderson, Morad C. Malek, Rachael A. Jonas-Closs, Yongmin Cho, Leonid Peshkin, Marc W. Kirschner, Lev Y. Yampolsky
Summary: The effects of maternal age on offspring life history vary and have specific mechanisms. In this study, the specific impact of maternal age on offspring longevity and the propensity to produce male offspring was observed. These effects can be explained by maternal lipid provisioning during embryonic development.
AMERICAN NATURALIST
(2022)
Article
Ecology
Prem Aguilar, Berfin Dag, Pau Carazo, Zahida Sultanova
Summary: Advanced paternal age can modulate offspring quality via male- and/or female-driven processes, and these effects may be sex-specific. Using Drosophila melanogaster as a model organism, we found that paternal age caused an increase in offspring quality, and this increase was more pronounced in daughters.
JOURNAL OF EVOLUTIONARY BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Elizabeth A. DeVilbiss, Alexandra C. Purdue-Smithe, Lindsey A. Sjaarda, Brandie D. Taylor, Joshua R. Freeman, Neil J. Perkins, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford
Summary: We examined the association between preconception adiposity and offspring sex and sex ratio. Among women attempting pregnancy, higher levels of adiposity were associated with reduced sex ratio, primarily driven by a decrease in male livebirths. Obesity and higher levels of serum leptin and skinfold measurements were significantly associated with lower sex ratios. This study highlights the importance of preconception adiposity in determining offspring sex and sex ratio.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Amna Khalid, Rizwan Qaisar, M. Azhar Hussain, Asima Karim
Summary: This study found that girls living at higher latitudes have a delayed age at menarche. Higher latitude is associated with lower levels of circulating follicle stimulating hormone (FSH) and physical growth parameters such as body mass index (BMI), waist-hip ratio, and waist-height ratio. On the other hand, lower socio-economic status (SES) is associated with lower growth hormone (GH) levels and lower BMI.
Article
Biology
Wenjie Li, Cuijuan Niu, Shijun Bian
Summary: Classic population regulation theories focus on immediate factors influencing current populations, while studies on parental environment factors and their effects on offspring populations are scarce. Maternal environments can influence offspring life-history traits across generations, potentially affecting population dynamics and serving as a mechanism for population regulation.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Perret Martine, Anzeraey Aude
Summary: Parental age at conception has a significant impact on the longevity of offspring, particularly the age of the mother. However, the age of the father has a minimal effect on offspring longevity. The longevity of female offspring is positively correlated with the longevity of both parents.
Article
Public, Environmental & Occupational Health
Misao Fukuda, Kiyomi Fukuda, Shawn Mason, Kenichi Tatsumi, Takashi Shimizu, Taiichiro Akahori, Tsunekazu Matsumoto, Masahiro Tahara, Claus Yding Andersen
Summary: This study found that contralateral ovulation and specific ovulation patterns were associated with offspring sex ratios, with younger women more likely to have male offspring. Right-sided ovulation favored male offspring, while left-sided ovulation favored female offspring, with differences observed in infertile women compared to fertile women.
REPRODUCTIVE HEALTH
(2022)
Article
Zoology
Ryan C. Scauzillo, Karl N. Rohrer, Michael H. Ferkin
Summary: There is a potential relationship between parental age and offspring sex ratios in meadow voles. Older fathers tend to sire more sons, possibly due to selective forces of competition, while middle-aged mothers tend to sire more sons, possibly to produce offspring that can better survive and compete.
JOURNAL OF MAMMALOGY
(2022)
Article
Ecology
Denyelle A. V. Kilgour, Courtney R. R. Linkous, Todd W. W. Pierson, Sarah Guindre-Parker
Summary: The Trivers-Willard hypothesis suggests that mothers adjust their offspring sex ratio based on their own condition and breeding environment. This study investigates the impact of urbanization on parental body condition and secondary offspring sex ratios in European starlings. The results indicate that parental body condition and site did not affect the production of male offspring, but the similarity of maternal and paternal CORT levels may increase the likelihood of successfully fledging sons.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Pediatrics
Minning Cheng, Ying Yao, Yuxin Zhao, Yizhou Lin, Si Gao, Juan Xie, Xin Zhang, Hong Zhu
Summary: In this study, urban girls were found to experience menarche earlier than rural girls, and this urban-rural difference could not be explained by family income, parental education, weight status of the participants and their parents, participants' physical exercise, and sleeping hours. Higher parental education was associated with earlier onset of menarche, but this association disappeared after adjustment for living residence.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Agriculture, Dairy & Animal Science
R. M. Garcia-Garcia, M. Arias-Alvarez, M. Rodriguez, A. Sanchez-Rodriguez, N. Formoso-Rafferty, P. L. Lorenzo, P. G. Rebollar
Summary: This study investigated the effects of restricting food intake in the early stages of pregnancy on reproductive outcomes and offspring viability in primiparous female rabbits. The results showed that food restriction did not have significant effects on conception rate, embryo survival, foetal size, weight, and other variables.
Article
Agriculture, Dairy & Animal Science
Joaquim Casellas, Marta Vasquez-Gomez, Samir Id-Lahoucine, Melani Martin de Hijas-Villalba
Summary: Offspring sex ratio in livestock populations can be influenced by environmental and genetic factors. This study used a new analytical approach to investigate the effects of environmental factors, inbreeding, and potential new mutations on offspring sex ratio in sheep and rabbit populations.
Article
Endocrinology & Metabolism
Sandro C. Esteves, Alessandro Conforti, Sesh K. Sunkara, Luigi Carbone, Silvia Picarelli, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo, Claus Yding Andersen, Raoul Orvieto, Peter Humaidan, Carlo Alviggi
Summary: The POSEIDON criteria were developed to help identify low-prognosis patients undergoing assisted reproductive technology and guide therapeutic strategies. However, existing evidence shows inconsistent and incomplete reporting, prompting the development of guidelines to improve reporting quality. The ultimate goal is to advance knowledge on the clinical use of POSEIDON criteria for the benefit of patients, clinicians, and the infertility community.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Stine Gry Kristensen, Yu Wakimoto, Lotte Berdiin Colmorn, Margit Dueholm, Susanne Elisabeth Pors, Kirsten Tryde Macklon, Linn Salto Mamsen, Dmitry Nikiforov, Jesus Cadenas, Vinnie Hornshoj Greve, Anne-Mette Bay Bjorn, Mikkel Rosendahl, Anette Tonnes Pedersen, Anders Nyboe Andersen, Jens Fedder, Erik Ernst, Claus Yding Andersen
Summary: This study evaluated the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort, revealing that OTT rates depended on diagnosis, age at OTC, and follow-up time. Longer follow-up is needed, especially for younger girls.
FERTILITY AND STERILITY
(2021)
Article
Genetics & Heredity
Jesus Cadenas, Dmitry Nikiforov, Susanne Elisabeth Pors, Lenin Arturo Zuniga, Yu Wakimoto, Zeinab Ghezelayagh, Linn Salto Mamsen, Stine Gry Kristensen, Claus Yding Andersen
Summary: The study found that adding 70 or 250 IU/L FSH to the IVM medium improved oocyte nuclear maturation by regulating gene expression in cumulus cells, suggesting a threshold for FSH concentration during IVM of human oocytes from small follicles. Moreover, FSH functions in vitro by downregulating FSHR and upregulating LHCGR in cumulus cells, which facilitates the maturation of immature oocytes.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Linn Salto Mamsen, Hanna Ornes Olesen, Susanne Elisabeth Pors, Xiaohui Hu, Peter Bjerring, Kare Christiansen, Cristina Subiran Adrados, Claus Yding Andersen, Stine Gry Kristensen
Summary: This study investigated whether Er:YAG laser treatment could improve re-vascularization and follicle survival in human ovarian tissue xenotransplantation. The results showed no positive effect on follicle density, suggesting further studies are needed to fully explore the potential angiogenic effects of controlled tissue damage using different intensities or lasers.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Multidisciplinary Sciences
Katherine S. Ruth, Felix R. Day, Jazib Hussain, Ana Martinez-Marchal, Catherine E. Aiken, Ajuna Azad, Deborah J. Thompson, Lucie Knoblochova, Hironori Abe, Jane L. Tarry-Adkins, Javier Martin Gonzalez, Pierre Fontanillas, Annique Claringbould, Olivier B. Bakker, Patrick Sulem, Robin G. Walters, Chikash Terao, Sandra Turon, Momoko Horikoshi, Kuang Lin, N. Charlotte Onland-Moret, Aditya Sankar, Emil Peter Thrane Hertz, Pascal N. Timshel, Vallari Shukla, Rehannah Borup, Kristina W. Olsen, Paula Aguilera, Monica Ferrer-Roda, Yan Huang, Stasa Stankovic, Paul R. H. J. Timmers, Thomas U. Ahearn, Behrooz Z. Alizadeh, Elnaz Naderi, Irene L. Andrulis, Alice M. Arnold, Kristan J. Aronson, Annelie Augustinsson, Stefania Bandinelli, Caterina M. Barbieri, Robin N. Beaumont, Heiko Becher, Matthias W. Beckmann, Stefania Benonisdottir, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig E. Bojesen, Manjeet K. Bolla, Dorret I. Boomsma, Nicholas Bowker, Jennifer A. Brody, Linda Broer, Julie E. Buring, Archie Campbell, Harry Campbell, Jose E. Castelao, Eulalia Catamo, Stephen J. Chanock, Georgia Chenevix-Trench, Marina Ciullo, Tanguy Corre, Fergus J. Couch, Angela Cox, Laura Crisponi, Simon S. Cross, Francesco Cucca, Kamila Czene, George Davey Smith, Eco J. C. N. de Geus, Renee de Mutsert, Immaculata De Vivo, Ellen W. Demerath, Joe Dennis, Alison M. Dunning, Miriam Dwek, Mikael Eriksson, Tonu Esko, Peter A. Fasching, Jessica D. Faul, Luigi Ferrucci, Nora Franceschini, Timothy M. Frayling, Manuela Gago-Dominguez, Massimo Mezzavilla, Montserrat Garcia-Closas, Christian Gieger, Graham G. Giles, Harald Grallert, Daniel F. Gudbjartsson, Vilmundur Gudnason, Pascal Guenel, Christopher A. Haiman, Niclas Hakansson, Per Hall, Caroline Hayward, Chunyan He, Wei He, Gerardo Heiss, Miya K. Hoffding, John L. Hopper, Jouke J. Hottenga, Frank Hu, David Hunter, Mohammad A. Ikram, Rebecca D. Jackson, Micaella D. R. Joaquim, Esther M. John, Peter K. Joshi, David Karasik, Sharon L. R. Kardia, Christiana Kartsonaki, Robert Karlsson, Cari M. Kitahara, Ivana Kolcic, Charles Kooperberg, Peter Kraft, Allison W. Kurian, Zoltan Kutalik, Martina La Bianca, Genevieve LaChance, Claudia Langenberg, Lenore J. Launer, Joop S. E. Laven, Deborah A. Lawlor, Loic Le Marchand, Jingmei Li, Annika Lindblom, Sara Lindstrom, Tricia Lindstrom, Martha Linet, YongMei Liu, Simin Liu, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Massimo Mangino, Arto Mannermaa, Brumat Marco, Jonathan Marten, Nicholas G. Martin, Hamdi Mbarek, Barbara McKnight, Sarah E. Medland, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Lili Milani, Roger L. Milne, Grant W. Montgomery, Dennis O. Mook-Kanamori, Antonella Mulas, Anna M. Mulligan, Alison Murray, Mike A. Nalls, Anne Newman, Raymond Noordam, Teresa Nutile, Dale R. Nyholt, Andrew F. Olshan, Hakan Olsson, Jodie N. Painter, Alpa V. Patel, Nancy L. Pedersen, Natalia Perjakova, Annette Peters, Ulrike Peters, Paul D. P. Pharoah, Ozren Polasek, Eleonora Porcu, Bruce M. Psaty, Iffat Rahman, Gad Rennert, Hedy S. Rennert, Paul M. Ridker, Susan M. Ring, Antonietta Robino, Lynda M. Rose, Frits R. Rosendaal, Jacques Rossouw, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia F. Sala, Emmanouil Saloustros, Dale P. Sandler, Serena Sanna, Elinor J. Sawyer, Chloe Sarnowski, David Schlessinger, Marjanka K. Schmidt, Minouk J. Schoemaker, Katharina E. Schraut, Christopher Scott, Saleh Shekari, Amruta Shrikhande, Albert V. Smith, Blair H. Smith, Jennifer A. Smith, Rossella Sorice, Melissa C. Southey, Tim D. Spector, John J. Spinelli, Meir Stampfer, Doris Stoeckl, Joyce B. J. van Meurs, Konstantin Strauch, Unnur Styrkarsdottir, Anthony J. Swerdlow, Toshiko Tanaka, Lauren R. Teras, Alexander Teumer, Unnur thorsteinsdottir, Nicholas J. Timpson, Daniela Toniolo, Michela Traglia, Melissa A. Troester, Therese Truong, Jessica Tyrrell, Andre G. Uitterlinden, Sheila Ulivi, Celine M. Vachon, Veronique Vitart, Uwe Voelker, Peter Vollenweider, Henry Voelzke, Qin Wang, Nicholas J. Wareham, Clarice R. Weinberg, David R. Weir, Amber N. Wilcox, Ko Willems van Dijk, Gonneke Willemsen, James F. Wilson, Bruce H. R. Wolffenbuttel, Alicja Wolk, Andrew R. Wood, Wei Zhao, Marek Zygmunt, Zhengming Chen, Liming Li, Lude Franke, Stephen Burgess, Patrick Deelen, Tune H. Pers, Marie Louise Grondahl, Claus Yding Andersen, Anna Pujol, Andres J. Lopez-Contreras, Jeremy A. Daniel, Kari Stefansson, Jenny Chang-Claude, Yvonne T. van der Schouw, Kathryn L. Lunetta, Daniel I. Chasman, Douglas F. Easton, Jenny A. Visser, Susan E. Ozanne, Satoshi H. Namekawa, Petr Solc, Joanne M. Murabito, Ken K. Ong, Eva R. Hoffmann, Anna Murray, Ignasi Roig, John R. B. Perry
Summary: A study identified 290 genetic determinants of ovarian aging, associated with DNA damage response processes and loss-of-function variants in key DDR-associated genes. Experimental models showed that these DDR processes act across the life-course to shape ovarian reserve and its rate of depletion. Extending reproductive life in women may improve bone health and reduce the risk of type 2 diabetes, but it could increase the risk of hormone-sensitive cancers.
Article
Reproductive Biology
Susanne Elisabeth Pors, Stine Gry Kristensen, Dmitry Nikiforov, Linn Salto Mamsen, Jesus Cadenas, Vinnie Hornshoj Greve, Margit Dueholm, Claus Yding Andersen
Summary: This study aimed to investigate the stability of pH when transporting ovarian tissue in media buffered with HEPES or histidine, and the impact of transport media choice on in vitro maturation rate of oocytes collected in connection with ovarian tissue cryopreservation. The results showed that the pH in histidine buffered media is closer to physiological levels and more stable than in HEPES buffered media, supporting the use of histidine buffered media for cooled transportation of human ovaries.
JOURNAL OF OVARIAN RESEARCH
(2021)
Editorial Material
Endocrinology & Metabolism
Sandro C. Esteves, Claus Yding Andersen, Robert Fischer, Peter Humaidan, Carlo Alviggi
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Richelle D. Bjorvang, Marie-Therese Vinnars, Nikos Papadogiannakis, Sebastian Gidlof, Linn Salto Mamsen, Daniel Mucs, Hannu Kiviranta, Panu Rantakokko, Paivi Ruokojarvi, Christian H. Lindh, Claus Yding Andersen, Pauliina Damdimopoulou
Summary: The study found that more chemicals were detected in fetal tissues compared to maternal serum and placenta, which may provide a misleading picture of actual fetal exposures.
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grondahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
Summary: The use of letrozole during ovarian stimulation for IVF did not significantly decrease the proportion of women with premature progesterone levels above 1.5 ng/ml at the time of triggering final oocyte maturation. However, letrozole did significantly increase the proportion of women with mid-luteal progesterone levels above 30 ng/ml.
HUMAN REPRODUCTION
(2022)
Review
Urology & Nephrology
Christian F. S. Jensen, Lihua Dong, Murat Gul, Mikkel Fode, Simone Hildorf, Jorgen Thorup, Eva Hoffmann, Dina Cortes, Jens Fedder, Claus Y. Andersen, Jens Sonksen
Summary: Treatment for childhood cancer may lead to infertility in survivors, but there are options for fertility preservation such as sperm or testis tissue cryopreservation. Physicians should inform patients and parents about the reproductive effects of treatment and provide relevant choices. Fertility preservation options for pre-pubertal boys are limited globally, while preservation for pubertal boys is clinically proven.
NATURE REVIEWS UROLOGY
(2022)
Review
Obstetrics & Gynecology
Dmitry Nikiforov, Marie Louise Grondahl, Julius Hreinsson, Claus Yding Andersen
Summary: Assessment of oocyte morphology can impact treatment outcomes, with certain abnormalities potentially affecting the results. Overall, morphology assessment is informative but not predictive, and combining artificial intelligence with oocyte morphology assessment may improve the accuracy of treatment outcomes.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Jesus Catienas, Liv la Cour Poulsen, Linn Salto Mamsen, Claus Yding Andersen
Summary: In several mammalian species, oocytes from small antral follicles after in vitro maturation (IVM) are successfully used for procreation. Humans are the exception, mainly due to limited access to immature oocytes and unique regulation of oocyte maturation. However, recent findings suggest that human IVM can be developed, with factors such as oocyte diameter, follicle size, hormone levels, and cumulus-oocyte complex secretion influencing the maturation process. Furthermore, studies on signal transduction pathways and hormone levels during physiological conditions provide new insights for improving the current IVM platform. With continued research efforts, it is envisioned that a human IVM platform equally effective as in other mammalian species can be achieved. (Fertil Sterile 2023;119:550-9. (c) 2023 by American Society for Reproductive Medicine.)
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
J. Cadenas, L. C. Poulsen, D. Nikiforov, M. L. Grondahl, A. Kumar, K. Bahnu, A. L. M. Englund, J. Malm, G. Marko-Varga, I Pla, A. Sanchez, S. E. Pors, C. Yding Andersen
Summary: This study investigates the substances and signal transduction pathways involved in the regulation of human oocyte maturation downstream to the effects of FSH and LH. The results reveal that human oocyte maturation is a multifactorial process involving several different signal transduction pathways. Various pathways, including those involving CNP, EGF-related peptides, TGF-beta family members, activins/inhibins, FF-MAS, and MDK, are potentially active, while the GDF9 and BMP15 pathways show less pronounced influence.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Agnieszka Katarzyna Warzecha, Mette Villads Nielsen, Claus Yding Andersen, Marianne Dreyer Holt, Morten Ronn Petersen, Negjyp Sopa, Anne Zedeler, Anne Lis Englund, Anja Pinborg, Marie Louise Grondahl, Sven Olaf Skouby, Nicholas Stephen Macklon
Summary: LZ co-treatment during ovarian stimulation with gonadotropins for in IVF does not impact follicle recruitment, oocyte number and quality, embryo quality, or live birth rate (LBR).
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Mengxue Zheng, Jesus Cadenas, Susanne Elisabeth Pors, Tasnim Esa, Stine Gry Kristensen, Linn Salto Mamsen, Cristina Subiran Adrados, Claus Yding Andersen
Summary: This study aimed to optimize the culture conditions for murine preantral follicles to improve their growth and survival. The results showed that altering the alginate concentration, adding estradiol, and increasing follicle-stimulating hormone concentration can promote the growth and development of preantral follicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
