Article
Endocrinology & Metabolism
Marlene Hager, Didier Dewailly, Rodrig Marculescu, Stefan Ghobrial, John Preston Parry, Johannes Ott
Summary: In a retrospective cohort study, it was found that women with stress-induced functional hypothalamic amenorrhea (FHA) have a higher prevalence of polycystic ovarian morphology (PCOM) compared to women with exercise-induced FHA. The stress group also exhibited higher levels of prolactin and a trend towards higher levels of dehydroepiandrosterone-sulphate (DHEAS). This suggests that the well-known stress sensitivity in women with polycystic ovary syndrome (PCOS) may explain their propensity to develop FHA and the high prevalence of PCOM in FHA women.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Clara Selzer, Johannes Ott, Didier Dewailly, Rodrig Marculescu, Johanna Steininger, Marlene Hager
Summary: The aim of this study was to assess prolactin levels in FHA patients and controls and factors influencing prolactin levels. The results showed that women with FHA have similar prolactin levels to healthy age-matched individuals. Eating disorders and excessive exercise were associated with prolactin levels < 12 μg/L, while TSH was associated with prolactin levels > 12 μg/L.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Neurosciences
Carlo Pruneti, Sara Guidotti
Summary: This study found that patients with Functional Hypothalamic Amenorrhea (FHA) exhibit autonomic hyper-activation and psychological distress. Therefore, a multimodal, multidimensional, and multidisciplinary assessment of stress is necessary for evaluating this condition.
Review
Nutrition & Dietetics
Karina Ryterska, Agnieszka Kordek, Patrycja Zaleska
Summary: Functional hypothalamic amenorrhea is a common condition affecting women of procreative age, characterized by a variety of factors such as stress, poor nutrition, and excessive exercise. Therapeutic interventions may not address all causes, potentially impacting women's health. Research suggests that modifying the underlying causes can reverse this condition.
Article
Agriculture, Dairy & Animal Science
Hehe Liu, Xia Xiong, Fajun Pu, Jianmei Wang, Yanying Li, Yang Xi, Shengchao Ma, Lili Bai, Rongping Zhang, Li Liang, Chaowu Yang
Summary: This study revealed that high stocking density negatively affects the reproductive performance in ducks. Transcriptome analysis identified differentially expressed genes (DEGs) in the hypothalamus, pituitary, ovary, and follicular membrane, showing their crucial roles in regulating stress response and reproduction.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
L. Fontana, E. Garzia, G. Marfia, V. Galiano, M. Miozzo
Summary: Functional hypothalamic amenorrhea (FHA) is a temporary female infertility caused by the suppression of the HPG axis due to stress factors. Recent studies have shown a genetic and epigenetic contribution to FHA, and induced pluripotent stem cells (iPSCs) have been used to study the molecular pathways involved.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Jingyi Sun, Mujiao Li, Yuting Xiong, Lingling Zhai, Jian Zhao
Summary: This study investigated the mechanism of oxidative stress mediated by N6-methyladenosine (m6A) methylation contributing to high fat diet-induced reproductive dysfunction. The results showed that high fat diet led to decreased sperm count, sperm motility, testosterone, luteinizing hormone levels, hyaluronidase, acrosomal enzyme levels, and total antioxidant capacity. Malondialdehyde levels increased while the expression of Nrf2, SOD1, and NQO1 decreased significantly. m6A levels in the testis tissue increased, along with an increase in m6A regulatory proteins. In vitro experiments showed that ROS levels decreased while Nrf2 expression increased in cells treated with S-Adenosylhomocysteine and gene silencing. Additionally, m6A expression decreased. Therefore, oxidative stress mediated by m6A methylation may contribute to high fat diet-induced male reproductive dysfunction.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxu Wang, Xincen Wang, Peixu Cong, Lulu Wu, Yingxu Ma, Zhigao Wang, Tianyu Jiang, Jie Xu
Summary: This study demonstrates that dietary ether-phospholipids (ether-PLs) can alleviate high-fat diet-induced hepatic lipid accumulation and regulate hypothalamic autophagy. Ether-PLs activate autophagy in the hypothalamus, which helps maintain energy balance and ameliorate the effects of chronic high-fat diet-induced obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Juliette Di Francesco, Gabriela F. Mastromonaco, Janice E. Rowell, John Blake, Sylvia L. Checkley, Susan Kutz
Summary: This study measured physiological stress response in muskoxen by measuring fecal glucocorticoid metabolite levels following ACTH injections in winter and summer. Results showed variability in fecal cortisol levels and a clearer response in fecal corticosterone levels, influenced by seasonal factors and individual differences.
Review
Nutrition & Dietetics
Danai Barlampa, Maria Sotiria Bompoula, Alexandra Bargiota, Sophia Kalantaridou, George Mastorakos, Georgios Valsamakis
Summary: PCOS is the most common endocrine disorder among women of reproductive age, and the inflammation in the hypothalamus caused by a high-fat and -sugar diet may play a role in its pathophysiology. Targeting these mechanisms could lead to effective therapies for PCOS treatment.
Article
Endocrinology & Metabolism
Eatemad A. Awadalla, Abd El-Kader M. Abd El-Kader, Samia A. Gbr, Amna H. Nour, Mohammed H. Hassan
Summary: The study aimed to evaluate the protective effects of α-lipoic acid against octylphenol-induced male infertility. The results showed that octylphenol caused abnormalities in serum reproductive hormone levels and oxidative stress levels, as well as histopathological and histochemical abnormalities in hypothalamus, pituitary, and testicular tissues. However, these derangements were successfully reversed by α-lipoic acid through its antioxidant and anti-inflammatory properties.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Engineering, Environmental
Ying Zhang, Yang Yang, Yue Tao, Xiangyong Guo, Yunhe Cui, Zixu Li
Summary: This study systematically reviewed the adverse effects of multiple PAEs on the HPG axis and discussed the possible underlying mechanisms. Abnormal release of gonadotropin-releasing hormone and gonadotropin, dysfunction of sex hormone receptors and steroid hormone synthesis, and general damage were confirmed to be involved in this process. This study aimed to provide reliable potential biomarkers for future environmental risk assessment and epidemiological investigation of PAEs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Martina Capuzzo, Antonio La Marca
Summary: This review discusses the role of anti-mullerian hormone (AMH) in the differential diagnosis of anovulatory disorders, focusing on its value in predicting the severity of the disease. Current limitations and potential future clinical applications are also addressed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Chrisandra L. Shufelt, Mariam Saadedine, Galen Cook-Wiens, Margareta D. Pisarska, JoAnn E. Manson, Sarah L. Berga, Moshe Arditi, Prediman K. Shah, C. Noel Bairey Merz
Summary: This study found that about one-third of women with functional hypothalamic amenorrhea (FHA) had endothelial dysfunction. FHA may be a preclinical cardiovascular disease (CVD) marker, and its occurrence is not solely explained by hypoestrogenemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)