Article
Obstetrics & Gynecology
N. Friis Wang, J. W. Bogstad, S. E. Pors, M. R. Petersen, A. Pinborg, C. Yding Andersen, K. Lossl
Summary: Continuous low-dose hCG administration for 8 weeks does not increase the proportion of antral follicles reaching the preovulatory state in women with low ovarian reserve.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Yun Sun, Linlin Cui, Yao Lu, Jichun Tan, Xi Dong, Tianxiang Ni, Junhao Yan, Yichun Guan, Guimin Hao, Jia-Yin Liu, Bo Zhang, Daimin Wei, Yan Hong, Yaqiong He, Jia Qi, Bing Xu, Juanjuan Lu, Qian Zhang, Shanshan Zhao, Xiaowei Ji, Xiaofang Du, Jie Zhang, Jinyong Liu, Jing Wang, Yingqin Huang, Dongmei Huang, Yanzhi Du, Hugo Vankelecom, Heping Zhang, Zi-jiang Chen
Summary: Prednisone treatment does not improve live birth rate in patients with recurrent implantation failure compared to placebo. The use of prednisone may increase the risk of preterm delivery and biochemical pregnancy loss. These findings challenge the value of prednisone use in clinical practice for the treatment of recurrent implantation failure.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Sarit Uzzan, Abed N. Azab
Summary: Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood disorders. This study found that chronic combined treatment attenuated LPS-induced hypothermia and reduced cytokine levels, suggesting a potential approach for treating inflammation-related mental illness. The treatment also showed antidepressant-like effects.
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Alla Shnaider, Sarit Uzzan, Ahmad Nassar, Adi Jabarin, Naim Abu-Freha, Karen Meir, Abed N. Azab
Summary: Chronic low-dose aspirin can mitigate the typical renal side effects of standard-dose lithium and enhance the beneficial behavioral effects of low-dose lithium therapy without aggravating its toxicity.
Article
Medicine, General & Internal
Emmanuelle Mathieu d'Argent, Celia Ravel, Alexandra Rousseau, Karine Morcel, Nathalie Massin, Julie Sussfeld, Tabassome Simon, Jean-Marie Antoine, Jacqueline Mandelbaume, Emile Darai, Kamila Kolanska
Summary: High-dose folic acid supplementation in men with male infertility undergoing IVF-ICSI has been shown to increase the biochemical pregnancy rate, reduce DNA fragmentation, and potentially improve the clinical pregnancy rate. Despite no observed changes in sperm characteristics, folic acid supplementation appears to have a positive impact on IVF-ICSI outcomes for male infertility patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Martina Balli, Anna Cecchele, Valerio Pisaturo, Sofia Makieva, Giorgia Carullo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano'
Summary: This article reviews the advantages and limitations of conventional IVF and discusses fundamental questions related to the technique. It provides insights into the opportunities and best practices in human c-IVF in the field of reproductive medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ilaria D'Agostino, Stefania Tacconelli, Annalisa Bruno, Annalisa Contursi, Luciana Mucci, Xiaoyue Hu, Yi Xie, Raja Chakraborty, Kanika Jain, Angela Sacco, Mirco Zucchelli, Raffaele Landolfi, Melania Dovizio, Lorenza Falcone, Patrizia Ballerini, John Hwa, Paola Patrignani
Summary: Enhanced platelet activation, systemic TXA(2) biosynthesis, and TP gene expression were found in patients with essential hypertension and a salt-sensitive hypertension mouse model, highlighting the role of the unconstrained TXA(2)/TP pathway in their pathophysiology. Low-dose Aspirin selectively inhibiting platelet TXA(2) production was effective in reducing blood pressure and preventing early cardiac fibrosis in these hypertensive conditions.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Yuan Zhang, Yunjie Song, Xinru Xia, Jing Wang, Yi Qian, Chun Yuan, Yundong Mao, Feiyang Diao, Jiayin Liu, Xiang Ma
Summary: This study found that anticoagulant therapy can significantly improve live birth rate, pregnancy rate, and reduce miscarriage rate in infertile women with persistent aPL positive. Combination treatment of aspirin and LMWH showed better results compared to monotherapy. For high-risk aPL positive infertile population, aspirin plus LMWH adjuvant treatment is recommended.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Wentao Rao, Yuying Li, Nijie Li, Qingyun Yao, Yufeng Li
Summary: This study evaluated the association between caffeine and alcohol consumption and in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes. The results showed that caffeine consumption was not significantly associated with IVF/ICSI outcomes, while maternal alcohol consumption was negatively associated with pregnancy rate and paternal alcohol consumption was negatively associated with partner's live birth rate after IVF/ICSI treatment.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Oncology
Mehrnoosh Shahrivar, Caroline E. Weibull, Karin Ekstrom Smedby, Bengt Glimelius, Ingvar Syk, Peter Matthiessen, Caroline Nordenvall, Anna Martling
Summary: In this large nationwide cohort study, there was no convincing association between aspirin use after colorectal cancer and overall survival or colorectal cancer-specific survival.
Article
Cell Biology
Sofia Makieva, Celine Staehli, Min Xie, Ana Velasco Gil, Maike Katja Sachs, Brigitte Leeners
Summary: This study aimed to determine the association between the time interval from insemination to vitrification and pregnancy rate. The findings suggest that the latest timing of vitrification is significantly associated with a higher pregnancy rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Si Sun, HongYang Qian, Congcong Li, Qiaohong Wang, Aimin Zhao
Summary: This study retrospectively investigated the safety of low dose aspirin (LDA) during pregnancy. The results showed that the use of aspirin did not increase the risk of fetal congenital anomalies. Additionally, a previous history of fetal abnormalities was found to be an independent risk factor for congenital anomalies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Oncology
Johannes Wach, Agi Gueresir, Hartmut Vatter, Ulrich Herrlinger, Albert Becker, Marieta Toma, Michael Hoelzel, Erdem Gueresir
Summary: In non-skull-base meningiomas, the use of low-dose acetylsalicylic acid (ASA) can lower the MIB-1 index and preoperative seizure burden, especially in elderly female patients. NSAIDs may have an anti-proliferative effect and reduce symptomatic burden caused by inflammation.