Article
Obstetrics & Gynecology
David J. McLernon, Edwin-Amalraj Raja, James P. Toner, Valerie L. Baker, Kevin J. Doody, David B. Seifer, Amy E. Sparks, Ethan Wantman, Paul C. Lin, Siladitya Bhattacharya, Bradley J. Van Voorhis
Summary: This study aims to develop in vitro fertilization (IVF) prediction models to estimate individualized chances of cumulative live birth, providing guidance for IVF treatment at different time points.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Mingze Du, Junwei Zhang, Zhancai Wei, Li Li, Xinmi Liu, Manman Liu, Xingling Wang, Yichun Guan
Summary: A retrospective cohort study found no evidence that season and temperature on oocyte retrieval day affect the cumulative live birth rate and time to live birth.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhuoyao Mai, Manlin Liu, Ping Pan, Lin Li, Jia Huang, Xiaoli Chen, Dongzi Yang
Summary: This study found that women with PCOS aged 35 years and older had a higher cumulative live birth rate over two years of IVF/ICSI cycles compared with age- and BMI-matched controls. Factors such as the number of transferable embryos and antral follicle counts were significant predictors of cumulative live birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Ze Wang, Yueru Meng, Xue Shang, Lu Suo, Dingying Zhao, Xinwei Han, Min Yang, Mengfei Yin, Haozhe Miao, Yixuan Wang, Huiming Yang, Yunhai Yu, Daimin Wei, Zi-Jiang Chen
Summary: This study aimed to evaluate the association between different interpregnancy interval (IPI) lengths after a preceding clinical pregnancy loss (CPL) and pregnancy outcomes of the next frozen embryo transfer (FET). The study found that delaying the next FET for at least 6 months after a preceding CPL was associated with beneficial pregnancy outcomes, considering that a decreased likelihood of achieving clinical pregnancy and live birth was observed among women with shorter IPIs.
Article
Obstetrics & Gynecology
Neal Mahutte, Michael Hartman, Lynn Meng, Andrea Lanes, Zhong-Cheng Luo, Kimberly E. Liu
Summary: The thickness of the endometrium has a significant impact on live birth rates in fresh and frozen-thaw embryo transfer cycles. In fresh cycles, increasing endometrial thickness can improve live birth rates until it reaches 10-12 mm, while in frozen cycles, live birth rates plateau after the endometrium measures 7-10 mm. Endometrial thickness below 6 mm is clearly associated with a dramatic reduction in live birth rates.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Wei Wu, Li-Feng Zhang, Yi-Ting Li, Tian-Xiao Hu, Dan-Qing Chen, Yong-Hong Tian
Summary: This study investigated the characteristics of hCG levels and rise patterns in patients with gestational diabetes mellitus (GDM) after in vitro fertilization (IVF). The results showed that there was no substantial difference in hCG rise curves between the GDM and non-GDM groups, and low hCG values in early pregnancy may be a clue to help predict GDM in subsequent gestation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Dang Kien Nguyen, Sean O'Leary, Moustafa Abdelhafez Gadalla, Bronnie Roberts, Helen Alvino, Kelton P. Tremellen
Summary: This study found that serum AMH levels can predict cumulative live birth rates to some extent following IVF/ICSI treatment. Women with higher AMH levels had higher CLBR, while those with lower AMH levels may take longer to achieve a successful pregnancy.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Giulia Scaravelli, Carlotta Zaca, Paolo Emanuele Levi Setti, Claudia Livi, Filippo Maria Ubaldi, Maria Teresa Villani, Ermanno Greco, Maria Elisabetta Coccia, Alberto Revelli, Giuseppe Ricci, Francesco Fusi, Vincenzo Vigiliano, Roberto De Luca, Simone Bolli, Andrea Borini
Summary: The study revealed a positive association between fertilization rate and CLBR, suggesting the predictive clinical relevance of this parameter and its adoption as a key performance indicator.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
James Zhang, Deepon Bhaumik, David Meltzer
Summary: The access barrier to medication has been a persistent challenge in healthcare systems worldwide. This longitudinal study examines the cost-related medication non-adherence (CRN) behaviors among different generational cohorts in the US. The findings suggest that as Americans age, there is a decrease in CRN rates independent of disease burden, income, and insurance status, indicating a changing pattern of medication adherence behaviors.
Article
Obstetrics & Gynecology
Sara Batha, Goli Ardestani, Olcay Ocali, Pam Jarmuz, Denis A. Vaughan, C. Brent Barrett, Denny Sakkas
Summary: The use of r-ICSI can eliminate concerns about total fertilization failure (TFF) after conventional IVF (C-IVF) and achieve high live birth rates after frozen blastocyst transfer.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Federica Zullo, Valentina Fiano, Anna Gillio-Tos, Sara Leoncini, Ginevra Nesi, Luigia Macri, Mario Preti, Alessandro Rolfo, Chiara Benedetto, Alberto Revelli, Laura De Marco
Summary: This study aims to evaluate the impact of HPV infection on IVF process and outcome. The results showed that HPV infection has a slight effect on the kinetic of embryonic development, but does not affect live birth rate.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Kenny A. Rodriguez-Wallberg, Hanna P. Nilsson, Tekla Lind
Summary: This study conducted a systematic review and meta-analysis to quantify the impact of unilateral oophorectomy (UO) on the rates of live birth and pregnancy in women undergoing IVF/ICSI. The results showed that women with previous UO had significantly lower rates of live birth and pregnancy, as well as higher doses of administered gonadotropins and a lower number of retrieved oocytes.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Haiyan Zhu, Chenqiong Zhao, Yibin Pan, Hanjing Zhou, Xiaoying Jin, Wen Xu, Songying Zhang
Summary: Dual trigger for final follicular maturation improves the cumulative pregnancy and live-birth rates compared with hCG trigger in freeze-all IVF/ICSI cycles.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Xiaoyan Liu, Zhiyun Chen, Yanqin Ji
Summary: This study developed prediction models based on parameters before and after the first IVF cycle to predict live births in women. The LGBM model showed good predictive performance in predicting live birth before and after the first cycle in women who underwent IVF.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Medicine, General & Internal
Akanksha Sood, Gadha Mohiyiddeen, Gaity Ahmad, Cheryl Fitzgerald, Andrew Watson, Lamiya Mohiyiddeen
Summary: The use of growth hormone (GH) as an adjuvant treatment in IVF has uncertain effects on live birth rates and number of oocytes retrieved in normal responders. However, it may slightly increase the number of oocytes retrieved and pregnancy rates in poor responders. The results need to be interpreted cautiously due to small sample sizes, bias, and variability in GH doses and regimens used in the trials. Additional research is needed to further define the role of GH in IVF as adjuvant therapy.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Endocrinology & Metabolism
Sallwa M. Alshehre, Sheila Duffy, Georgina Jones, William L. Ledger, Mostafa Metwally
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Ali Aflatounian, Melissa C. Edwards, Valentina Rodriguez Paris, Michael J. Bertoldo, Reena Desai, Robert B. Gilchrist, William L. Ledger, David J. Handelsman, Kirsty A. Walters
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Cell Biology
Yuliya Makeyeva, Christopher Nicol, William L. Ledger, David K. Ryugo
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Review
Obstetrics & Gynecology
Georgina M. Chambers, Elena Keller, Stephanie Choi, Yakoub Khalaf, Sara Crawford, Willings Botha, William Ledger
FERTILITY AND STERILITY
(2020)
Article
Multidisciplinary Sciences
Valentina Rodriguez Paris, Samantha M. Solon-Biet, Alistair M. Senior, Melissa C. Edwards, Reena Desai, Nicodemus Tedla, Madeleine J. Cox, William L. Ledger, Robert B. Gilchrist, Stephen J. Simpson, David J. Handelsman, Kirsty A. Walters
NATURE COMMUNICATIONS
(2020)
Article
Obstetrics & Gynecology
Angelique H. Riepsamen, Mark W. Donoghoe, Angela Baerwald, Michael W. Pankhurst, Shelly Lien, Yih Harng Chong, David M. Robertson, William L. Ledger, Robert B. Gilchrist
Summary: This study characterized and evaluated the variation in serum concentrations of GDF9 and BMP15 across the menstrual cycle in women of different reproductive ages. The researchers found that there were minimal changes in GDF9 or BMP15 concentrations within a woman across the cycle, and the variance was highest in the luteal phases for BMP15. Further research is needed to fully understand the utility of these oocyte biomarkers for diagnosing fertility potential and disease.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Hang Wun Raymond Li, David Mark Robertson, Chris Burns, William Leigh Ledger
Summary: Serum anti-Mullerian hormone (AMH) is a key marker for ovarian reserve, used in infertility treatment, menopause prediction, and polycystic ovarian syndrome diagnosis. There are 21 different commercial AMH immunoassay platforms, but there is a lack of international standardization for calibration.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Erin M. Nesbitt-Hawes, Hans Peter Dietz, William L. Ledger, Jason A. Abbott
Summary: This study demonstrates a weak correlation between 4DUS biometry of the pelvic floor and clinical pain and vaginal pressure outcomes in the context of BoNT-A injection for PFTM treatment.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Reproductive Biology
Jennifer K. Y. Ko, Andrew Kan, Peter Leung, Vivian C. Y. Lee, Raymond H. W. Li, William Ledger, Ernest H. Y. Ng
Summary: This study compared the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing IVF using a standardized stimulation regimen. Despite Chinese women being older, having a higher BMI, longer duration of infertility, and lower AFC, they had a higher number of oocytes compared to Caucasian women after controlling for age, BMI, AFC, and AMH. Ethnicity was found to be a significant independent determinant of the number of oocytes obtained.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Geriatrics & Gerontology
Jared M. Campbell, Saabah B. Mahbub, Michael J. Bertoldo, Abbas Habibalahi, Dale M. Goss, William L. Ledger, Robert B. Gilchrist, Lindsay E. Wu, Ewa M. Goldys
Summary: Increasing age has a negative impact on female fertility due to deteriorating quality of oocytes. The use of nicotinamide mononucleotide (NMN) has been shown to restore oocyte quality and fertility in aged animals. Identifying the multispectral profile of oocyte autofluorescence during aging could serve as a non-invasive and sensitive measure of oocyte quality.
Article
Obstetrics & Gynecology
Stephanie K. Y. Choi, Christos Venetis, William Ledger, Alys Havard, Katie Harris, Robert J. Norman, Louisa R. Jorm, Georgina M. Chambers
Summary: In a country with supportive funding for medically assisted reproduction (MAR) technologies, the proportion of MAR births increased from 5.1% in 2009 to 6.7% in 2017, with ART births increasing by 55% and stable contribution from OI/IUI births.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Ting Xiong, Valentina Rodriguez Paris, Melissa C. Edwards, Ying Hu, Blake J. Cochran, Kerry-Anne Rye, William L. Ledger, Vasantha Padmanabhan, David J. Handelsman, Robert B. Gilchrist, Kirsty A. Walters
Summary: AR signaling in white and brown adipose tissue, but less likely in skeletal muscle, is involved in the development of metabolic PCOS traits, highlighting the importance of androgen actions in adipose tissue and obesity in the manifestation of metabolic disturbances.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Abbas Habibalahi, Jared M. Campbell, Michael J. Bertoldo, Saabah B. Mahbub, Dale M. Goss, William L. Ledger, Robert B. Gilchrist, Lindsay E. Wu, Ewa M. Goldys
Summary: The purpose of this study is to develop a deep radiomic signature based on an artificial intelligence model, which can accurately identify oocyte morphological changes associated with reproductive aging. By employing deep learning, swarm intelligence, and discriminative analysis, a highly informative signature was obtained and applied to distinguish oocytes from different age groups. The results showed that the signature could successfully differentiate morphological changes in oocytes, reflecting the decline in oocyte quality.
Article
Health Care Sciences & Services
Georgina M. Chambers, Stephanie K. Y. Choi, Katie Irvine, Christos Venetis, Katie Harris, Alys Havard, Robert J. Norman, Kei Lui, William Ledger, Louisa R. Jorm
Summary: This study describes the creation and performance of a bespoke population-based data linkage of an ART clinical quality registry to state-based and national administrative datasets, demonstrating high linkage rates and high concordance in birth data, supporting the evaluation of long-term health outcomes of ART treatment.
INTERNATIONAL JOURNAL OF POPULATION DATA SCIENCE (IJPDS)
(2021)
Article
Endocrinology & Metabolism
Valentina Rodriguez Paris, Melissa C. Edwards, Ali Aflatounian, Michael J. Bertoldo, William L. Ledger, David J. Handelsman, Robert B. Gilchrist, Kirsty A. Walters
Summary: PCOS is a common disorder with unclear etiology and pathogenesis, managed based on symptoms. A PCOS mouse model showed that irregular cycles, anovulation, and weight gain are early features, while adiposity, impaired glucose tolerance, and dyslipidemia are later characteristics. These findings support early diagnosis with body weight criteria.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)