Biological Evaluation of Halogenated Thioureas as Cholinesterases Inhibitors Against Alzheimer's Disease & Molecular Modeling Studies

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition is thought to be an encouraging approach towards the therapy of Alzheimer's disease (AD). The current paper targets to give a concise information of mono and dihalo-substituted thioureas similarity with anti-AD potential. The present results represent evaluation of cholinesterase inhibitory potential for halogenated thioureas derivatives. Compound 1t was constituted to be highly potent inhibitor with K-i value 0.12 +/- 0.05 mu M against AChE, while 1b was most the active inhibitor for BChE with K-i value of 0.03 +/- 0.001 mu M. Molecular docking simulations were performed using the homology models of both cholinesterases in order to explore the plausible binding modes of synthesized compounds.