Article
Oncology
Lei Wang, Xiu-Xiu Liu, Yu-Meng Yang, Yan Wang, Yuan-Yuan Song, Shan Gao, Lu-Yuan Li, Zhi-Song Zhang
Summary: The study identified the important role of rhomboid family genes in the progression of kidney renal clear cell carcinoma, particularly highlighting the correlation between high expression levels of RHBDF2 gene and poor prognosis in the disease. Furthermore, it revealed that high RHBDF2 expression may promote cell migration in cancer tissues and inhibit immune cell activity by sustaining PD-L1 protein levels.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Huiming Jiang, Haibin Chen, Pei Wan, Meng Liang, Nanhui Chen
Summary: TMEM45A is significantly overexpressed in ccRCC patients, correlated with poor overall survival, and may promote tumorigenesis and metastasis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jiajin Wu, Chenkui Miao, Yuhao Wang, Songbo Wang, Zhongyuan Wang, Yiyang Liu, Xiaoyi Wang, Zengjun Wang
Summary: This study demonstrates that SPTBN1 is significantly down-regulated in ccRCC and its knockdown promotes ccRCC progression. Overexpression of SPTBN1 reverses this effect. Further investigations reveal that SPTBN1 mediates ccRCC development through the GPT2-dependent glycolysis pathway and regulates the mRNA stability of GPT2 as an RNA-binding protein.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xinwei Ma, Xiaoqi Wang, Qian Dong, Hongquan Pang, Jianming Xu, Junkang Shen, Jianbing Zhu
Summary: This study revealed that IRF6 is down-regulated in ccRCC and correlates with poor prognosis, while KIF20A is up-regulated and associated with prognosis in ccRCC. It was also found that IRF6 can affect ccRCC cell proliferation, invasion, and migration by inhibiting KIF20A.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Fan Zhang, Junyu Lin, Dechao Feng, Jiayu Liang, Yiping Lu, Zhihong Liu, Xianding Wang
Summary: This study explored the correlation between cuprotosis and clear cell renal cell carcinoma (ccRCC) and developed a cuprotosis-related signature to predict the prognosis of patients with ccRCC. The signature risk score was significantly associated with tumor stage, histological grade, and immune cell infiltrates in ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Juan Chen, Xiaoliang Hua, Heying Chen, Xiangmin Qiu, Haibing Xiao, Shengdong Ge, Chaozhao Liang, Qin Zhou
Summary: PKMYT1 expression is closely associated with the pathological features of ccRCC and may participate in the tumorigenesis and progression of ccRCC by affecting cell cycle-related pathways and the EMT process. Knockdown of PKMYT1 in vitro can reduce the growth, migration, and invasion ability of RCC cells, promote cell apoptosis, and prevent the occurrence of the EMT phenotype.
Article
Cell Biology
Zonglong Wu, Yimeng Song, Yaqian Wu, Liyuan Ge, Zhuo Liu, Tan Du, Shudong Zhang, Lulin Ma
Summary: This study identified metastasis-related genes in clear cell renal cell carcinoma (ccRCC) and constructed a metastasis-associated prognostic gene signature. Kinesin family member 23 (KIF23) was identified as a prognostic marker in ccRCC patients, and inhibition of KIF23 expression reduced ccRCC cell proliferation, migration, and invasion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pathology
Yingting Liu, Zhaoyu Xing, Maoling Yuan, Bin Xu, Lujun Chen, Dachuan Zhang, You Zhou, Hao Huang, Xiao Zheng, Jinping Zhang, Jingting Jiang
Summary: The expression of IL1R2 is associated with tumor grade and prognosis in ccRCC, and it can serve as an independent prognostic predictor. The regulation of IL1R2 affects the cellular functions of ccRCC cells and involves the JAK2/STAT3 signaling pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Yixing Yang, Fengwen Ye, Tianxiang Xia, Qianwen Wang, Jun Du
Summary: This study investigates the expression and prognostic value of MICAL1 in renal clear cell carcinoma. The findings suggest that high MICAL1 expression is associated with poorer prognosis and increased cell migration in this type of cancer. MICAL1 also appears to play a role in regulating the tumor immune microenvironment.
Article
Genetics & Heredity
You Zuo, Shuai Fu, Zhongwei Zhao, Zeyan Li, Yijian Wu, Tienan Qi, Jianguo Zheng, Qinglong Du, Zhonghua Xu, Nengwang Yu
Summary: This study constructed a sarcomatoid-associated gene risk index (SAGRI) to predict the prognosis of renal cell carcinoma and found that SAGRI has a high predictive power. The study also suggested that the SAGRI-HIGH subgroup may benefit from immunotherapy.
FRONTIERS IN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Zuhu Yu, Chong Lu, Bin Lu, Hong Gao, Rongfang Liang, Wuxing Xiang
Summary: This study identified necroptosis-related microRNAs (miRNAs) associated with the prognosis of clear cell renal cell carcinoma (ccRCC), and developed a prognostic signature to predict overall survival in ccRCC patients. The targeted genes of these miRNAs were predicted using miRNA databases, and their functional and pathway associations with ccRCC prognosis were investigated. The differential expression of the three miRNAs in the signature was validated in ccRCC tissues.
Article
Endocrinology & Metabolism
Hong Xie, Jun Song, Jason Godfrey, Romain Riscal, Nicolas Skuli, Itzhak Nissim, M. Celeste Simon
Summary: The accumulation of glycogen is a consistent feature of clear cell renal cell carcinoma (ccRCC). However, it has been found that glycogen is not essential for tumor cell proliferation and survival in ccRCC, both in vivo and in vitro. This suggests that glycogen build-up in ccRCC tumor cells may be a secondary and seemingly non-essential consequence of HIF-1 alpha signaling.
Article
Genetics & Heredity
Jie Ming, Chunyang Wang
Summary: This study identified m7G-related lncRNAs and constructed a 12 m7G-related lncRNA prognostic signature for clear cell renal cell carcinoma (ccRCC) using transcriptome data and clinical data from TCGA. The risk signature showed high accuracy and reliability in predicting overall survival (OS) of ccRCC patients. Additionally, functional enrichment analysis and immunological analysis were performed, providing insight into the biological pathways and immune characteristics of ccRCC.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xianhui Liu, Weiyu Zhang, Huanrui Wang, Lin Zhu, Kexin Xu
Summary: ACADSB plays an important role in the diagnosis and prognosis of ccRCC. Its downregulation may promote tumorigenesis and tumor progression. The expression level of ACADSB can serve as a significant parameter to discriminate between normal and tumor tissues.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yue Wu, Xi Zhang, Xian Wei, Huan Feng, Bintao Hu, Zhiyao Deng, Bo Liu, Yang Luan, Yajun Ruan, Xiaming Liu, Zhuo Liu, Jihong Liu, Tao Wang
Summary: By analyzing differentially expressed ubiquitin-related genes in ccRCC, seven prognostic-related genes were identified and used to construct a predictive signature, which showed good prediction accuracy for evaluating tumor progression in ccRCC patients. The signature was confirmed to be an independent prognostic factor related to the prognosis of ccRCC patients, potentially providing diagnostic and prognostic markers for ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Seoil Moon, Goh Eun Chung, Sae Kyung Joo, Jeong Hwan Park, Mee Soo Chang, Ji Won Yoon, Bo Kyung Koo, Won Kim
Summary: The PNPLA3 rs738409 genotype is associated with the risk of diabetes mellitus (DM), but this association differs between individuals with and without nonalcoholic fatty liver disease (NAFLD).
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dong Hyeon Lee, Se Un Sung, Yun Kyu Lee, Ik Hyeon Lim, Heejoon Jang, Sae Kyoung Joo, Jeong Hwan Park, Mee Soo Chang, Young Ho So, Won Kim
Summary: This study explores the optimal diagnostic approach to detect advanced fibrosis in patients with NAFLD by using models combining FIB-4 score and LSM. The study finds that LSM has good diagnostic performance in predicting fibrosis stages and is influenced by waist circumference, serum albumin, and fibrosis stage.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Yun-Cheng Hsieh, Sae Kyung Joo, Bo Kyung Koo, Han-Chieh Lin, Dong Hyeon Lee, Mee Soo Chang, Jeong Hwan Park, Young Ho So, Won Kim, ITEN
Summary: This study found that severe myosteatosis is significantly associated with early NASH and fibrosis progression in early stage NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Bo kyung Koo, Hyunsuk Lee, Soo-heon Kwak, Dong hyeon Lee, Jeong hwan Park, Won Kim
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Hyesung Kim, Seung Bum Lee, Jae Kyung Myung, Jeong Hwan Park, Eunsun Park, Dong Il Kim, Cheol Lee, Younghoon Kim, Chul-Min Park, Min Bum Kim, Gil Chai Lim, Bogun Jang
Summary: The study aimed to identify the major EMT-inducing transcription factor in pleomorphic adenoma (PA) and found that SLUG was significantly upregulated in both normal salivary glands and PA. SLUG was specifically expressed in the myoepithelial cells of normal salivary glands and neoplastic myoepithelial cells and stromal cells of PA. The study concluded that SLUG is a key regulator of EMT in PA and is less likely to be affected by PLAG1.
LABORATORY INVESTIGATION
(2022)
Article
Pathology
Minsun Jung, Min-Sun Jin, Chungyeul Kim, Cheol Lee, Ilias P. Nikas, Jeong Hwan Park, Han Suk Ryu
Summary: Accurate diagnosis and grading of prostate needle biopsies are crucial for prostate cancer management. An AI system called DeepDx has been developed to assist pathologists in making unbiased decisions and improve efficiency. This study validated the performance of DeepDx in prostate cancer diagnosis and grading, and demonstrated its potential value in routine practice by enhancing the general pathologist's diagnostic performance.
Article
Oncology
Jiwoong Jung, Ki-Tae Hwang, In Sil Choi, Byoung Hyuck Kim, Sohee Oh, Jongjin Kim, Jeong Hwan Park, Jin Hyun Park, Se Hyun Paek, Sook Young Jeon, Tae-Hoon Yeo
Summary: This study aimed to demonstrate racial differences in the predictive values of the 21-gene recurrence score (RS) assay. The results showed that the assay had a good predictive value for assessing chemotherapy benefit in White women, but this was not validated in non-White women, except for Black women with grade 3 tumors.
Article
Gastroenterology & Hepatology
Hyena Kang, Hyun Ju You, Giljae Lee, Seung Hyun Lee, Taekyung Yoo, Murim Choi, Sae Kyung Joo, Jeong Hwan Park, Mee Soo Chang, Dong Hyeon Lee, Won Kim, GwangPyo Ko
Summary: This study investigated the relationship between high carbohydrate intake and nonalcoholic fatty liver disease (NAFLD) and found that this relationship may be mediated by interactions between gut microbial modulation, impaired insulin response, and hepatic de novo lipogenesis.
Article
Gastroenterology & Hepatology
Su Hwan Kim, Ji Won Kim, Seong-Joon Koh, Sang Gyun Kim, Jeong Mo Bae, Jung Ho Kim, Jeong Hwan Park, Mee Soo Chang, Kee Don Choi, Hyoun Woo Kang, Byeong Gwan Kim, Kook Lae Lee
Summary: Tauroursodeoxycholic acid (TUDCA) protects gastric epithelial cells by inhibiting NF-kappa B signaling and ameliorating ethanol- and NSAID-induced gastritis.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Hyesung Kim, Dong Hui Lee, Eunsun Park, Jae Kyung Myung, Jeong Hwan Park, Dong Il Kim, Se Ik Kim, Maria Lee, Younghoon Kim, Chul Min Park, Chang Lim Hyun, Young Hee Maeng, Cheol Lee, Bogun Jang
Summary: This study investigated the expression and functional significance of LGR5 in human ovary tissues. The researchers found that LGR5 expression was negligible in the human ovary surface epithelium, but was present in ovarian stromal cells and in certain types of ovarian tumors. The study also discovered that LGR5 expression was associated with improved progression-free survival in high grade serous carcinoma (HGSC) patients and that LGR5 expression suppressed tumor proliferation and migratory capabilities in vitro assays.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Yongju Lee, Jeong Hwan Park, Sohee Oh, Kyoungseob Shin, Jiyu Sun, Minsun Jung, Cheol Lee, Hyojin Kim, Jin-Haeng Chung, Kyung Chul Moon, Sunghoon Kwon
Summary: This study demonstrates a method of using graph deep learning to extract prognostic histopathological features from the tumour microenvironment. By training a neural network model, interpretable features of the heterogeneous tumour microenvironment can be obtained, aiding diagnostic and prognostic tasks.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Oncology
Sun-ju Byeon, Mee Soo Chang, Hwa Jin Cho, Jeong Hwan Park, Ki Hwan Kim, Jin Hyun Park, In Sil Choi, Won Kim, Dong-Seok Han, Hye Seong Ahn, Seung Chul Heo
Summary: The expression of PD-L1 and leptin in biliary tract cancers is associated with prognosis, which may depend on tumor protein expression and anatomical site.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Tae Hoon Lee, Bum-Sup Jang, Ji Hyun Chang, Eunji Kim, Jeong Hwan Park, Eui Kyu Chie
Summary: This study aimed to identify genomic biomarkers in rectal cancer using whole-exome sequencing. Pre-chemoradiation (CRT) biopsy and post-CRT surgical specimens were obtained from 27 patients, and mutations and copy number alterations were analyzed in relation to clinical outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Il Jung, Min Hoan Moon, Chang Kyu Sung, Myoung Seok Lee, Jeong Hwan Park, Sohee Oh
Summary: This study aimed to assess the role of renal Doppler ultrasonography (US) in predicting non-diabetic kidney disease (NDKD) in patients with diabetes, using histologic findings as the reference standard. The results showed that the resistive index (RI) measured by renal Doppler US can be useful in predicting NDKD in patients with diabetes and chronic kidney disease (CKD).
Article
Oncology
Pamela Sung, Jong Yoon Lee, Jong-Ho Cheun, In Sil Choi, Jin Hyun Park, Jeong Hwan Park, Byoung Hyuck Kim, Sohee Oh, A. Jung Chu, Ki-Tae Hwang
Summary: This study investigated the implications of focal breast edema on preoperative breast magnetic resonance imaging (MRI) in patients with breast cancer. The study found that focal breast edema implies a higher possibility of lymphovascular invasion and axillary lymph node metastasis, which can lead to poor prognosis. Detailed description of edema on preoperative breast MRI, especially subcutaneous edema, may provide prognostic predictions.
JOURNAL OF BREAST CANCER
(2023)
