Article
Surgery
Neda Amini, Joseph R. Habib, Alex Blair, Neda Rezaee, Benedict Kinny-Koster, John L. Cameron, Ralph H. Hruban, Matthew J. Weiss, Elliot K. Fishman, Kelly J. Lafaro, Atif Zaheer, Lindsey Manos, William R. Burns, Richard Burkhart, Jin He, Jun Yu, Christopher L. Wolfgang
Summary: There is a risk of progression in the remnant pancreas after resection of noninvasive IPMNs, including both invasive and noninvasive progression. Multifocality and high-grade dysplasia are associated with invasive progression. Patients with high-risk features should be monitored more closely.
Article
Oncology
Timothy D. Jones, Liang Cheng
Summary: The distinction between PUNLMP and low-grade noninvasive papillary urothelial carcinoma is controversial and unnecessary for treatment and prognosis. Combining these two tumor types into a single category (NIPUN) can improve diagnostic accuracy among medical imaging observers.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Joseph G. Cheaib, Lauren E. Claus, Hiten D. Patel, Max R. Kates, Andres Matoso, Noah M. Hahn, Trinity J. Bivalacqua, Jean H. Hoffman-Censits, Phillip M. Pierorazio
Summary: Metastatic recurrence occurs in over 25% of upper tract urothelial carcinoma patients treated with radical nephroureterectomy, with lymphovascular invasion being a predictor of metastatic recurrence. Hepatic and osseous recurrences have relatively quicker onset and less favorable prognosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Medicine, Research & Experimental
Ava Slotman, Minqi Xu, Katherine Lindale, Celine Hardy, Dan Winkowski, Regan Baird, Lina Chen, Priti Lal, Theodorus van der Kwast, Chelsea L. Jackson, Robert J. Gooding, David M. Berman
Summary: This study aimed to measure morphometric features relevant to grading criteria in noninvasive papillary urothelial carcinoma (NPUC) and build simplified classification models to distinguish between different grades objectively. The findings indicate that nuclear morphometry and automated mitotic figure counts can be used to objectively differentiate the grades of NPUC. These quantitative elements have the potential to revolutionize pathologic assessment and improve the prognostic utility of grade.
LABORATORY INVESTIGATION
(2023)
Review
Medicine, Research & Experimental
Siyu Wu, Rong Li, Yuanhong Jiang, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Yang Wang, Zhenqun Xu, Shijie Li, Xiaonan Chen
Summary: Liquid biopsy is an accurate method for determining molecular profiles in urothelial carcinoma (UC). It has the potential to play a crucial role in early diagnosis, treatment monitoring, and prognosis prediction, thereby contributing to precision medicine in UC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ziyu Liu, Shumei Wei, Jinlong Tang
Summary: This study retrospectively evaluated the clinicopathologic features and recurrence rates of inverted noninvasive urothelial papillary tumors. The results showed that inverted papillary urothelial tumors have lower recurrence rates and better prognosis. The study identified tumor number as an important prognostic factor for the disease-free survival of low malignant potential and high-grade papillary urothelial carcinoma with an inverted growth pattern.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Article
Endocrinology & Metabolism
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Nabil Siraj, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study retrospectively analyzed 1283 patients with papillary thyroid carcinoma (PTC) and found a high incidence of bilateral multifocality. Bilateral multifocality was closely associated with clinical pathological characteristics such as age, gender, tumor size, and lymph node metastasis. It was also identified as an independent predictor of PTC recurrence. Therefore, patients with bilateral multifocal PTC may benefit from more frequent follow-up to detect recurrences earlier.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Johannes Bobjer, Oskar Hagberg, Firas Aljabery, Truls Gardmark, Staffan Jahnson, Tomas Jerlstrom, Amir Sherif, Athanasious Simoulis, Viveka Strock, Christel Haggstrom, Lars Holmberg, Fredrik Liedberg
Summary: This study found that compared to PUNLMP, TaG1 bladder cancer has a higher risk of recurrence, while progression events were too few to compare.
SCANDINAVIAN JOURNAL OF UROLOGY
(2022)
Article
Gastroenterology & Hepatology
Woo Hyun Paik, Hee Seung Lee, Kyong Joo Lee, Sung Ill Jang, Woo Jin Lee, Jin-Hyeok Hwang, Chang Min Cho, Chang-Hwan Park, Jimin Han, Sang Myung Woo, Seok Jeong, Hyung Ku Chon, Tae Nyeun Kim, Jun Kyu Lee, Joung-Ho Han, Jai Hoon Yoon, Yong-Tae Kim, Jae Hee Cho
Summary: This study investigated the clinical course and risk factors for malignant potential of small PNENs, finding that WHO grade is responsible for the malignant potential of small PNENs <= 2 cm. Therefore, EUS-FNAB could be recommended for early treatment strategies.
Article
Medicine, General & Internal
Sung Yong Han, Dong Uk Kim, Hyeong Seok Nam, Dae Hwan Kang, Sung Ill Jang, Dong Ki Lee, Dong Woo Shin, Kwang Bum Cho, Min Jae Yang, Jae Chul Hwang, Jin Hong Kim, Hoonsub So, Sung Jo Bang, Min Je Sung, Chang-Il Kwon, Dong Wook Lee, Chang-Min Cho, Jae Hee Cho
Summary: This study evaluated the predictors of malignancy in intraductal papillary neoplasm of the bile duct (IPNB) according to anatomical location and investigated the prognosis without surgery. The results showed that extrahepatic IPNB (E-IPNB) had a higher rate of malignancy than intrahepatic IPNB (I-IPNB), with mural nodule > 12 mm in I-IPNB and mural nodule enhancement in E-IPNB being predictive factors for malignancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Guoliang Zhang, Bing Li, Yuanmei Lin
Summary: ITGA3 is overexpressed in papillary thyroid carcinoma (PTC), especially in those with higher tumor invasion grades and lymph node metastasis, and was associated with recurrence and poor relapse-free survival (RFS) of PTC. High expression of ITGA3 may have the potential role of predicting PTC recurrence and lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen, Hong Shen
Summary: The study demonstrated that eIF6 expression was significantly increased in HCC and correlated with its pathological progression. eIF6 served as a new diagnostic biomarker and an independent risk factor for OS in HCC patients. Functional studies showed that deletion of eIF6 exhibited tumor-suppressor activity in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Joshua I. Warrick, Margaret A. Knowles, Carolyn D. Hurst, Lauren Shuman, Jay D. Raman, Vonn Walter, Jeffrey Putt, Lars Dyrskjot, Clarice Groeneveld, Mauro A. A. Castro, A. Gordon Robertson, David J. DeGraff
Summary: In this study, a transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma (NIPUC) was identified. The activity of transcription factors in this network was associated with mutational burden, copy number instability, and other characteristics. The findings suggest that transcription factor activity plays a prominent role in driving cell cycle dysregulation in NIPUC.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Xinyu Wang, Jingyu Deng, Han Liang
Summary: The study found that patients with papillary gastric adenocarcinoma (PGC) were generally older and had tumors located in the upper 1/3 of the stomach, with characteristics such as serosal infiltration and early lymph node metastasis. The risk factor for poor survival in PGC patients was papillary adenocarcinoma.
Article
Oncology
Yan Gui, Dongmei Huang, Yun Hou, Xudong Wei, Jinming Zhang, Junyi Wang
Summary: This retrospective study analyzed pediatric patients with papillary thyroid carcinoma (PTC) and found that younger patients had a higher risk of aggressive features and recurrence compared to older patients. The study suggests that prophylactic or therapeutic lymph node dissection should be considered for younger patients with positive preoperative thyroid-stimulating hormone (TSH), tumors larger than 2 cm, lateral lymph node metastases, and more than 5 lymph node metastases to reduce the risk of recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Haider A. Mejbel, Shuko Harada, Todd M. Stevens, Xiao Huang, George J. Netto, Alexander C. Mackinnon, Sameer Al Diffalha
Summary: MEIS1::NCOA1/2 sarcomas are rare low-grade tumors that often affect the genitourinary and gynecologic tracts. They can be diagnostically challenging due to their similarity to other entities, but molecular pathology plays a crucial role in arriving at an accurate diagnosis.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Medical Laboratory Technology
Jaylou M. Velez Torres, Manuel Lora Gonzalez, Ernesto Martinez Duarte, Bassel Zein-Sabatto, Manju Aron, Nilesh S. Gupta, Darcy A. Kerr, George J. Netto, Merce Jorda, Oleksandr N. Kryvenko
Summary: In this study, the features of pseudocarcinomatous urothelial hyperplasia (PCUH) in urine cytology were described. The results showed that PCUH features in urine cytology can overlap with nonurothelial malignancies and lead to misdiagnosis initially.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Editorial Material
Urology & Nephrology
George J. Netto, Mahul B. Amin, Eva M. Comperat, Anthony J. Gill, Arndt Hartmann, Holger Moch, Santosh Menon, Maria R. Raspollini, Mark A. Rubin, John R. Srigley, Puay Hoon Tan, Satish K. Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, Daniel M. Berney
Letter
Urology & Nephrology
Mark A. Rubin, Mahul B. Amin, Eva Comperat, Anthony Gill, Arndt Hartman, Santosh Menon, Maria Raspollini, John Srigley, Puay Hoon Tan, Satish Ticktoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, Daniel Berney, Holger Moch, George J. Netto
Article
Pathology
Yuki Teramoto, Numbereye Numbere, Ying Wang, Hiroshi Miyamoto
Summary: The laterality of perineural invasion (PNI) in prostate cancer has a significant impact on clinical outcomes. Patients with bilateral PNI have a higher risk of disease progression after radical prostatectomy (RP) compared to those with unilateral PNI.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Cell Biology
Hiroshi Miyamoto
Review
Oncology
Masato Yasui, Liam Cui, Hiroshi Miyamoto
Summary: Patients with non-muscle-invasive bladder tumor often experience recurrence even after surgery, and muscle-invasive disease is often fatal. It is crucial to understand the molecular mechanisms responsible for bladder tumor progression and tumorigenesis.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Pathology
Ying Wang, Yuki Teramoto, Hiroshi Miyamoto
Summary: It is controversial whether Gleason grade should be assigned to intraductal carcinoma of the prostate (IDC-P) and if the prognostic value of comedonecrosis associated with IDC-P is equivalent to that in conventional/invasive prostatic adenocarcinoma (CPA) as a Gleason grade 5 pattern. This study evaluated radical prostatectomy findings and postoperative outcomes in 287 patients with CPA exhibiting any Gleason pattern 5. The presence of necrosis only in IDC-P was found to be associated with significantly worse oncologic outcomes, compared with necrosis only in CPA, suggesting that IDC-P necrosis should not be simply considered as a grade 5 pattern.
Article
Oncology
Wilrama Lima, Ying Wang, Hiroshi Miyamoto
Summary: This study evaluated the clinical significance of intraoperative frozen section analysis (FSA) in patients with upper urinary tract cancer. The results showed that FSA can significantly reduce the risk of positive surgical margins in patients with ureteral tumors, but routine FSA for upper urinary tract cancer did not improve long-term oncologic outcomes significantly.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Urology & Nephrology
Yuki Teramoto, Ying Wang, Hiroshi Miyamoto
Summary: Quantification of perineural invasion on prostate biopsy showed significance as an independent predictor of prognosis, with multifocal perineural invasion and >1 perineural invasion per 10-mm tumor associated with worse outcomes after radical prostatectomy. Additionally, assigning points for multifocal perineural invasion improved the accuracy of predicting 5-year recurrence-free survival.
JOURNAL OF UROLOGY
(2023)
Letter
Pathology
Yuki Teramoto, Numbereye Numbere, Hiroshi Miyamoto
PATHOLOGY INTERNATIONAL
(2023)
Review
Chemistry, Medicinal
Tomoyuki Tatenuma, Hiroshi Miyamoto
Summary: Androgen deprivation therapy is the main treatment for advanced prostate cancer, and relugolix has been developed as an oral alternative. Previous studies have shown comparable efficacy between relugolix and other gonadotropin-releasing hormone antagonists or agonists. This review summarizes the design, development, and therapeutic application of relugolix and discusses its potential as a promising oral alternative to injectable therapy.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
Yuri Tolkach, Vlado Ovtcharov, Alexey Pryalukhin, Marie-Lisa Eich, Nadine Therese Gaisa, Martin Braun, Abdukhamid Radzhabov, Alexander Quaas, Peter Hammerer, Ansgar Dellmann, Wolfgang Hulla, Michael C. Haffner, Henning Reis, Ibrahim Fahoum, Iryna Samarska, Artem Borbat, Hoa Pham, Axel Heidenreich, Sebastian Klein, George Netto, Peter Caie, Reinhard Buettner
Summary: This retrospective study validates a deep learning-based classifier for prostate cancer (PCA) detection and Gleason grading (AI tool) in biopsy samples. The AI tool showed high accuracy in tumor detection and had similar accuracy in Gleason grading compared to experienced pathologists.
NPJ PRECISION ONCOLOGY
(2023)
Review
Pathology
Maria Rosaria Raspollini, Eva M. Comperat, Antonio Lopez-Beltran, Rodolfo Montironi, Alessia Cimadamore, Toyonori Tsuzuki, George J. Netto
Summary: The fifth edition of WHO Classification of Tumors series for urinary and male genital tract tumors has been published after six years of the fourth edition. New treatment approaches and molecular data on urological cancers have been implemented during these years. Although morphology remains the basis for taxonomy, a molecular approach and new therapeutic modalities like immunotherapy are emerging. More data is required for the application of these advances in routine pathology practice and patient management.
Article
Pathology
Manju Arona, Darshan S. Chandrashekarc, Sofia Canete-Portilloc, Fadi Brimod, Sean R. Williamsone, Adeboye O. Osunkoyaf, Maria Rosaria Raspollinih, Lakshmi P. Kunjui, Sooryanarayana Varamballyc, Alexander C. Mackinnonc, Shuko Haradac, George J. Nettoc
Summary: Nested urothelial carcinoma (NUC) and large nested urothelial carcinoma (LNUC) of the upper urinary tract are rare tumors. This study provides insights into their clinicopathological and molecular characteristics, revealing better clinical outcomes for LNUC and a higher prevalence of pathogenic mutations in FGFR3 and PIK3CA in LNUC.
