Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Veterinary Sciences
Ana R. Flores, Alexandra Rema, Joao R. Mesquita, Marian Taulescu, Fernanda Seixas, Fatima Gartner, Irina Amorim
Summary: This study found that abnormal expression of E-cadherin is associated with canine gastric cancer, and it may play a role in tumor progression and serve as a prognostic tool.
VETERINARY SCIENCES
(2022)
Article
Oncology
Mitsuhiro Nikaido, Nobuyuki Kakiuchi, Shin'ichi Miyamoto, Tomonori Hirano, Yasuhide Takeuchi, Taro Funakoshi, Akira Yokoyama, Tatsuki Ogasawara, Yoshihiro Yamamoto, Atsushi Yamada, Takeshi Setoyama, Takahiro Shimizu, Yukari Kato, Suguru Uose, Takaki Sakurai, Sachiko Minamiguchi, Kazutaka Obama, Yoshiharu Sakai, Manabu Muto, Tsutomu Chiba, Seishi Ogawa, Hiroshi Seno
Summary: The study found that CDH1 somatic mutation is a driver mutation for Hp-uninfected intramucosal DGC, while TP53 mutation is more common in advanced DGC. Intramucosal DGCs are mainly pure signet ring cell carcinoma with a lower likelihood of developing into advanced DGCs.
Review
Surgery
Naveena A. N. Kumar, Anmi Jose, Nawaz Usman, Keshava Rajan, Murali Munisamy, Preethi S. Shetty, Mahadev Rao
Summary: There has been an increasing incidence of signet ring cell cancer (SRCC) in the stomach and gastro-esophageal junction (GEJ), with multistage carcinogenesis involving genetic and epigenetic aberrations possibly playing a major role. Studies examining the prognostic value of SRCC have produced inconsistent results, making it difficult to draw meaningful conclusions. Specific therapeutic strategies and personalized multimodal treatments based on tumor characteristics are recommended for SRCC, with the need for further research in genetic and molecular analysis, histopathological classification, and treatment options to improve outcomes.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Review
Oncology
Yunjin Li, Yi Cao, Xiaoying Wu, Ruijie Liu, Kuansong Wang
Summary: This study reports a rare case of neuroendocrine tumor in the breast with a signet ring cell appearance. The documentation and literature review contribute to the understanding of the prognosis and management of this rare tumor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Biao Hu, Run-Pu Zou, Yin-Wen Gan, Yi-Hao Zhu, Si-Min Ren, Wei-Zhong Hou, Zhi-Xin Xie, Ru Wang, Wen-Ting Yang, Peng-Ji Lin, Jun-Tao Feng, Zi-Min Gao, Xu-Guang Guo
Summary: A predictive model was developed to identify which patients with signet ring cell carcinoma of the stomach would benefit from primary tumor operation, using clinical data from the SEER database. The model identified certain patients who benefited from the surgery, resulting in a longer cancer-specific survival time compared to non-benefiting patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yu Yang, Yuxuan Li, Xiaohui Du
Summary: This study compared the prognosis of hepatoid adenocarcinoma of the stomach (HAS) and gastric signet ring cell carcinoma (SRC) patients, showing no significant difference in overall survival between the two. However, in patients with advanced tumor stage, HAS may have a worse prognosis than SRC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Chi Zhang, Ran Liu, Wei-Han Zhang, Xin-Zu Chen, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Zhi-Xin Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study found that patients with signet ring cell gastric cancer are typically younger and more commonly female compared to those with non-signet ring cell gastric cancer. For early stage signet ring cell gastric cancer patients, they have a lower lymph nodes metastasis rate and comparable prognosis with non-signet ring cell cancers; however, in advanced tumor stage, signet ring cell gastric cancer has a significantly worse prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Weizhu Zhao, Yanfei Jia, Guangyu Sun, Haiying Yang, Luguang Liu, Xianlin Qu, Jishuang Ding, Hang Yu, Botao Xu, Siwei Zhao, Ligang Xing, Jie Chai
Summary: Gastric signet ring cell carcinoma (GSRC) is a distinct subtype of gastric cancer with poor prognosis, but there is a lack of in-depth and systematic study on GSRC. In this study, single-cell RNA sequencing was performed on GC samples, revealing the presence of signet ring cell carcinoma (SRCC) cells. These SRCC cells showed upregulation of genes involved in cancer-related and immune response signaling pathways. They also demonstrated lower cell adhesion, higher immune evasion capabilities, and an immunosuppressive microenvironment, which may contribute to the relatively poor prognosis of GSRC. Overall, GSRC exhibits unique cytological characteristics and a distinct immune microenvironment, which could be beneficial for accurate diagnosis and treatment.
NATURE COMMUNICATIONS
(2023)
Review
Genetics & Heredity
Mathis Lepage, Nancy Uhrhammer, Maud Privat, Flora Ponelle-Chachuat, Myriam Kossai, Julien Scanzi, Zangbewende Guy Ouedraogo, Mathilde Gay-Bellile, Yannick Bidet, Mathias Cavaille
Summary: Germline pathogenic variants in E-cadherin (CDH1) are associated with a high risk of developing lobular breast cancer and diffuse gastric cancer (DGC). The cumulative risk of DGC in CDH1 carriers has been reassessed recently, and the risk varies depending on the presence and number of gastric cancers in the family. The management of CDH1 carriers, particularly those with incidental findings, poses challenges for both patients and providers. This study reports on the management of the risk of DGC in a family with CDH1 carriers, as well as the incidental finding of a rare aggressive cancer in a CDH1 carrier.
Article
Oncology
Malin Enblad, Peter Pal Egerszegi, Helgi Birgisson, Tobias Sjoblom, Bengt Glimelius, Joakim Folkesson
Summary: Signet ring cell (SRC) carcinoma of colorectal and appendiceal cancer is rare but has the poorest prognosis. The prognostic relevance of a SRC component <50% is unclear. This study found that SRCs, both = 50% and <50%, were associated with aggressive histopathological features, advanced stages, and peritoneal metastases. It suggests that information about the presence of SRCs should be routinely registered to aid our understanding of SRCs in these cancers.
Article
Oncology
Yangkun Wang, Yingying Li, Bin Wang, Dongmei Ran, Chaoya Zhu, Ping Li, Bo Jiang, Sunan Wang
Summary: This study investigated the early onset, development, and histological features of gastric signet-ring cell carcinoma (SRCC). The results showed that gastric mucosa infection, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in specific areas of the stomach. SRCC grows infiltratively and can differentiate into various types of adenocarcinoma with signet-ring cell differentiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Katsunori Matsueda, Noriya Uedo, Masanori Kitamura, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Yoji Takeuchi, Koji Higashino, Ryu Ishihara, Tomoki Michida, Seiji Kawano, Yoshiro Kawahara
Summary: The endoscopic features of gastric neuroendocrine carcinoma (G-NEC) were investigated and compared with clinicopathological findings. Submucosal tumor-like marginal elevation (87%), adherent white coat (67%), and ulceration with a distinct border (60%) were characteristic endoscopic findings in white-light images. Magnifying narrow-band imaging endoscopy revealed an absent microsurface (MS) pattern plus disrupted irregular microvessel (MV) in the majority of cases.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Reidar Fossmark, Rune Johannessen, Gunnar Qvigstad, Patricia Mjones
Summary: Gastric neuroendocrine tumors (NETs) and signet ring cell carcinomas may have a common origin, with chronic atrophic gastritis, hypoacidity, and hypergastrinemia as shared risk factors.
MEDICINA-LITHUANIA
(2022)
Article
Oncology
Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li, Sheng Yan
Summary: The study showed that high vimentin expression with loss of E-cadherin expression in patients with grade 1 and 2 pNETs undergoing resection was correlated with risks of lymph node metastasis, distant metastasis, disease progression, and poor prognosis.