Journal
HUMAN PATHOLOGY
Volume 42, Issue 10, Pages 1562-1567Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2011.01.012
Keywords
ALK-positive large B-cell lymphoma; Cytogenetics
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Anaplastic lymphoma kinase positive large B-cell lymphoma is a rare non Hodgkin lymphoma that exhibits a characteristic immunoblastic/plasmablastic morphology and is frequently associated with t(2;17)(p23;q23) and expression of Clathrin anaplastic lymphoma kinase fusion protein. Here, we report a refractory anaplastic lymphoma kinase positive large B-cell lymphoma in a 49-year-old human immunodeficiency virus positive man. The neoplastic cells expressed CD 138, epithelial membrane antigen, CD45, and perforin, and showed a strong granular cytoplasmic anaplastic lymphoma kinase staining pattern. Conventional chromosome analysis revealed a clone with multiple anomalies and a chromosome count of 76 to 79. Fluorescence in situ hybridization studies showed 5 copies of the ALK gene with 2 intact signals and 3 signals resulting from 2 independent, previously unreported, rearrangements. One rearrangement, seen in 2 copies, involved translocation of ALK sequences to chromosome Xq21. The second rearrangement involved translocation of ALK sequences to chromosome 12q24.1. This case broadens the cytogenetic alterations in anaplastic lymphoma kinase-positive large B-cell lymphoma, and it also demonstrates the high genetic instability of this tumor. (C) 2011 Elsevier Inc. All rights reserved.
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