Article
Medicine, Research & Experimental
Junjiong Zheng, Sihong Lu, Yi Huang, Xu Chen, Jie Zhang, Yuhui Yao, Jinhua Cai, Jieying Wu, Jianqiu Kong, Tianxin Lin
Summary: This study confirms the prognostic value of preoperative FISH assay and proposes a FISH-clinical nomogram for predicting RFS in NMIBC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Donghao Shang, Yuting Liu, Xiuhong Xu, Zhenghao Chen, Daye Wang
Summary: The study found that both CellDetect and FISH have superior sensitivity in diagnosing UC compared to traditional urine cytology, with no significant difference in specificity. CellDetect shows varying sensitivity in different types and grades of UC, making it suitable for monitoring UC recurrence and screening undetectable cases.
CANCER CELL INTERNATIONAL
(2021)
Editorial Material
Oncology
Derek B. Allison
Summary: The study suggests that the variant morphologic findings of P-CIS are subtle and often do not meet the criteria for high-grade urothelial carcinoma according to the Paris System.
CANCER CYTOPATHOLOGY
(2021)
Article
Oncology
Bo Fan, Yuanbin Huang, Shuang Wen, Qiliang Teng, Xinrui Yang, Man Sun, Tingyu Chen, Yan Huang, Yumei Wang, Zhiyu Liu
Summary: Preoperative urine cytology has been validated as a potential predictor of intravesical recurrence in UUT-UC patients after RNU, with significant improvement in predictive efficacy and accuracy when combined with other factors. Preoperative positive urine cytology is associated with an increased risk of IVR and malignant biological behavior.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Tomomi Nakagawa, Kazuyoshi Shigehara, Yuki Kato, Shohei Kawaguchi, Hiroki Nakata, Taito Nakano, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Although urine and bladder washing samples are commonly used for cytological evaluation of the bladder, their suitability for investigating HPV prevalence in the urinary bladder has been unknown. This study found that the use of washing samples appears to be applicable in screening HPV infection in the urinary bladder, as HPV-DNA detected in these samples may frequently originate from the bladder.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chunjin Ke, Xuguang Liu, Jie Wan, Zhiquan Hu, Chunguang Yang
Summary: This study explores the application value of FISH in carcinoma of non-urothelial lineages (CNUL) for the first time. The results suggest that positive urine FISH tests not only indicate urothelial carcinoma (UC), but also CNUL. CNUL and UC show different genetic changes in FISH.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Christopher J. Vandenbussche, Christopher D. Heaney, Max Kates, John J. Hooks, Kelly Baloga, Lori Sokoll, Dorothy Rosenthal, Barbara Detrick
Summary: The presence of IL-6 and IL-8 in urine specimens may have predictive value for urothelial carcinoma. However, further long-term studies are needed to eliminate confounding factors and support this theory. In this study, the authors found significantly elevated concentrations of IL-6 and IL-8 in the urine of patients with urothelial carcinoma, indicating that the combination of IL-6 and IL-8 may serve as a potential marker for high-grade bladder cancer.
CANCER CYTOPATHOLOGY
(2023)
Article
Urology & Nephrology
Stefan Pycha, Emanuela Trenti, Christine Mian, Christine Schwienbacher, Esther Hanspeter, Margherita Palermo, Armin Pycha, Hansjorg Danuser, Carolina D'Elia
Summary: The study evaluated the performance of Xpert(R)-BC-Detection and Bladder-Epicheck(R)-test in the detection of upper urinary tract tumors (UTUC) and compared them with cytology and Urovysion(R)-FISH test. The results showed that Bladder-Epicheck(R) and Urovysion(R)-FISH, combined with cytology, could be helpful ancillary methods for the diagnosis of UTUC while Xpert(R)-BC-Detection had limited usefulness due to its low specificity.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Takashi Yokoyama, Makoto Toguchi, Junpei Iizuka, Shigeru Horita, Tsutomu Ishizuka, Yu Chu-Su, Yoji Nagashima, Toshio Takagi, Kazunari Tanabe, Yoshikazu Tokuoka
Summary: This study proposed a protocol that utilizes ALA-PpIX staining and ImageJ analysis to enhance the accuracy of urine cytology analysis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Urology & Nephrology
Lennert Eismann, Jan-Niclas Mumm, Lucas Bohn, Christian Wuelfing, Ruth Knuechel-Clarke, Jozefina Casuscelli, Raphaela Waidelich, Christian G. Stief, Boris Schlenker, Severin Rodler
Summary: The study showed that preoperative FISH diagnostics provide important information for the preoperative diagnostic workup of UTUC patients, with a significant shift towards lower T stages below T1 observed within organ-confined disease.
UROLOGIA INTERNATIONALIS
(2021)
Review
Andrology
Takashi Nagai, Taku Naiki, Toshiki Etani, Keitaro Iida, Yusuke Noda, Nobuhiko Shimizu, Teruki Isobe, Satoshi Nozaki, Takehiko Okamura, Ryosuke Ando, Noriyasu Kawai, Takahiro Yasui
Summary: Urothelial carcinoma (UC) is a high-incidence disease with a demand for easily and non-invasive detection methods. The UroVysion test, utilizing a multi-target, multicolor fluorescence in situ hybridization (FISH) assay, has been approved by the US FDA for nearly 20 years.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Louise C. McLoughlin, Sophie O'Halloran, Michael Tjong, Khaled Ajib, Katherine Lajkosz, Heather Ruff, Sikei Lou, Peter Chung, Srinivas Raman, Girish S. Kulkarni, Alexandre R. Zlotta, Neil E. Fleshner, Alejandro Berlin
Summary: This study investigates the significance of positive/equivocal cytology without visible disease following TMT for MIBC. Positive cytology is common and does not preclude subsequent negative cytology. However, cytology that remains positive at subsequent follow-up may be associated with adverse recurrence and survival outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Multidisciplinary Sciences
Shinsuke Oda, Masayoshi Fujisawa, Li Chunning, Toshihiro Ito, Takahiro Yamaguchi, Teizo Yoshimura, Akihiro Matsukawa
Summary: Aberrant activation of the Ras/Raf/ERK-MAPK pathway is involved in cancer progression, but the negative regulation by Spred2 may counter this progression in non-invasive bladder carcinoma. The loss of Spred2 regulation is associated with increased ERK activation and Ki67 index in more malignant cancers. Spred2 appears to be a key regulator in the progression of non-invasive bladder carcinoma.
Review
Biochemistry & Molecular Biology
Vincenzo Fiorentino, Cristina Pizzimenti, Mariausilia Franchina, Esther Diana Rossi, Pietro Tralongo, Angela Carlino, Luigi Maria Larocca, Maurizio Martini, Guido Fadda, Francesco Pierconti
Summary: The management of NMIBC requires monitoring and evaluation methods such as urinary cytology, cystoscopy, and radiological assessment of the upper urinary tract. Urine cytology and methylation analysis are commonly used methods with high sensitivity for detecting high-grade bladder carcinoma and carcinoma in situ. The combined use of urine cytology and methylation analysis can diagnose high-grade bladder carcinoma and predict clinical and histological recurrences in doubtful cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Koji Shiraishi, Seiji Kitahara, Hideaki Ito, Kazuo Oba, Chietaka Ohmi, Hideyasu Matsuyama
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Oncology
Hiroaki Matsumoto, Kazuhiro Nagao, Masahiro Samoto, Junichi Mori, Kosuke Shimizu, Ryo Inoue, Yoshiaki Yamamoto, Seiji Yano, Hiroshi Hirata, Tomoyuki Shimabukuro, Hideyasu Matsuyama
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Junichi Inokuchi, Kentaro Kuroiwa, Hiroyuki Nishiyama, Takahiro Kojima, Yoshiyuki Kakehi, Mikio Sugimoto, Toshiki Tanikawa, Hiroyuki Fujimoto, Momokazu Gotoh, Naoya Masumori, Osamu Ogawa, Masatoshi Eto, Chikara Ohyama, Akito Yamaguchi, Hideyasu Matsuyama, Tomohiko Ichikawa, Keiichi Ito, Junki Mizusawa, Junko Eba, Seiji Naito
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Shuji Mikami, Ryuichi Mizuno, Tsunenori Kondo, Nobuo Shinohara, Norio Nonomura, Seiichiro Ozono, Masatoshi Eto, Katsunori Tatsugami, Tatsuya Takayama, Hideyasu Matsuyama, Takeshi Kishida, Mototsugu Oya
Article
Pharmacology & Pharmacy
Yoshiaki Yamamoto, Toru Otori, Ryo Inoue, Seiji Yano, Hiroshi Hirata, Hiroaki Matsumoto, Kenji Matsuyama, Hideyasu Matsuyama
JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Urology & Nephrology
Koji Shiraishi, Masanori Tabara, Hideyasu Matsuyama
JOURNAL OF UROLOGY
(2020)
Article
Oncology
Masaki Shiota, Naohiro Fujimoto, Yoshiaki Yamamoto, Ario Takeuchi, Katsunori Tatsugami, Takeshi Uchiumi, Hideyasu Matsuyama, Masatoshi Eto
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Urology & Nephrology
Kimihiko Nakamura, Yudai Nagata, Toshiya Hiroyoshi, Naohito Isoyama, Koki Fujikawa, Yutaka Miura, Hideyasu Matsuyama, Makoto Kuro-o
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Article
Oncology
Atsushi Ikeda, Takahiro Kojima, Koji Kawai, Shiro Hinotsu, Naoto Keino, Kenichiro Shiga, Hideaki Miyake, Yasuyoshi Miyata, Yutaka Enomoto, Fumitaka Shimizu, Satoshi Anai, Hideyasu Matsuyama, Chieko Suzuki, Yusuke Kanimoto, Keisuke Shigeta, Seiji Naito, Hideyuki Akaza, Hiroyuki Nishiyama
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Immunology
Yuki Nakayama, Naohito Isoyama, Takeshi Yamamoto, Yudai Nagata, Masafumi Matsumura, Koki Fujikawa, Hideyasu Matsuyama, Koji Shiraishi
TRANSPLANT IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Makito Miyake, Nagaaki Marugami, Yuya Fujiwara, Kazumasa Komura, Teruo Inamoto, Haruhito Azuma, Hiroaki Matsumoto, Hideyasu Matsuyama, Kiyohide Fujimoto
Article
Oncology
Makito Miyake, Hideyasu Matsuyama, Satoshi Teramukai, Fumie Kinoshita, Isao Yokota, Hiroaki Matsumoto, Keiji Shimada, Mitsuru Kinjyo, Tatsuro Shimokama, Koji Okumura, Masaya Yomenori, Hideki Enokida, Masayuki Nakagawa, Yasushi Nakai, Kiyohide Fujimoto
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Yoshiaki Yamamoto, Hideyasu Matsuyama, Hiroaki Matsumoto, Shigeru Sakano, Nakanori Fuji, Kazuo Oba, Mitsutaka Yamamoto, Yoriaki Kamiryo, Takeshi Hiragino, Kazuhiro Nagao, Kimio Takai, Akihiko Aoki
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Kazuhiro Suzuki, Nobuaki Matsubara, Hirotaka Kazama, Takeshi Seto, Shoko Tsukube, Hideyasu Matsuyama
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2019)
Review
Obstetrics & Gynecology
Koji Shiraishi, Hideyasu Matsuyama
REPRODUCTIVE MEDICINE AND BIOLOGY
(2019)