Article
Dentistry, Oral Surgery & Medicine
J. J. Wu, L. W. Ma, C. H. Jiang, J. Chen, N. Li, X. Q. Chen, A. J. Min, W. J. Wang, Y. Q. Hu, X. Gao
Summary: This study aims to evaluate the rare postoperative supraclavicular metastasis originating from oral squamous cell carcinoma (OSCC) and discuss the potential predictive marker of epidermal growth factor receptor (EGFR). The findings suggest that supraclavicular metastasis of OSCC is infrequent and associated with a poor prognosis, and EGFR might predict the occurrence of supraclavicular metastasis.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Plant Sciences
Lorenzo Alibardi, Marta Surbek, Leopold Eckhart
Summary: EPS8L1 is expressed in the terminally differentiated cells of human epidermis, and it has also been detected in the granular layer of mammalian epidermis as well as the inner root sheath of hair follicles. EPS8L1 may have a role in regulating the skin barrier.
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Jacqueline S. Gerritsen, Joseph S. Faraguna, Rudy Bonavia, Frank B. Furnari, Forest M. White
Summary: This study investigated the relationship between specific EGFR phosphorylation sites and the signaling network as well as cell response. The results showed that the EGFR network remains resilient even with multiple Y-to-F mutations in the C-terminal tail. Additionally, the study revealed previously unidentified network nodes associated with EGFR signaling. The data-driven model highlighted the signaling network nodes associated with distinct EGF-driven cell responses.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Oncology
Yu-Jin Wang, Qing-Wen Wang, Dong-Hu Yu, Cong-Kuan Song, Zi-Xin Guo, Xiao-Ping Liu, Chen Chen, Jie Yao, Ai-Fen Wang, Wei-Dong Hu
Summary: The correlation between Osteopontin (OPN) and EGFR affects the sensitivity of lung adenocarcinoma (LUAD) cells to the first-generation TKI gefitinib, suggesting OPN as a potential target for molecular therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Pathology
Claud M. Grigg, Chad Livasy, Jiaxian He, Aaron Hartman, Peter E. Clark, Jason Zhu, Derek Raghavan, Earle F. Burgess
Summary: The study evaluated the concordance of HER2 expression in primary urothelial carcinomas and distant metastatic lesions, finding low agreement of HER2-positive status between the two, with loss of HER2 overexpression in some cases. The presence of HER2 ITH impacted the concordance, potentially influencing patient selection for HER2 targeted therapies.
Article
Oncology
Ruimin He, Xiaohua Yang, Tengxiang Li, Yaolin He, Xiaoxue Xie, Qilei Chen, Zijian Zhang, Tingting Cheng
Summary: This study aimed to find a novel data-driven genetic testing method that can effectively predict the mutation status of EGFR based on a prediction model combining clinical features. The results showed that the subset of radiographic and clinical features selected by feature engineering effectively predicted the EGFR mutation status of this NSCLC patient cohort.
Article
Neurosciences
Zachary Beine, Zimei Wang, Pantelis Tsoulfas, Murray G. Blackmore
Summary: This study analyzed neurons projecting from the brain to the spinal cord in mice, identifying 14 transcriptionally distinct cell types and marker genes. The findings provide insights into the molecular characteristics and physiological functions of supraspinal cell populations.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Hui Hu, Xiao-Wei Zhang, Lin Li, Ming-Ning Hu, Wen-Qian Hu, Jing-Ying Zhang, Xiao-Kang Miao, Wen-Le Yang, Ling-Yun Mou
Summary: Non-small cell lung cancer (NSCLC) is the most common cancer in the world, and Gefitinib has been shown to be effective in treating NSCLC. However, innate and acquired resistance present challenges in therapy. Inhibition of autophagy is considered a promising strategy to overcome resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Carolien Eggermont, Philippe Giron, Maxim Noeparast, Hugo Vandenplas, Pedro Aza-Blanc, Gustavo J. Gutierrez, Jacques De Greve
Summary: In this study, a high-throughput siRNA kinome screen was performed to identify targets involved in functional drug tolerance against EGFR TKI in NSCLC. STYK1 was identified as a potential target that, when downregulated, enhances the effects of EGFR inhibition. The study also found that STYK1 selectively interacts with mutant EGFR and that its downregulation counteracts the upregulation of FGF1 induced by EGFR TKI. Co-targeting EGFR and STYK1 could lead to a better overall outcome for NSCLC patients.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Joanne L. Peterson, Brian P. Ceresa
Summary: Maintaining proper structure and function of the cornea is essential for clear vision. The epidermal growth factor receptor (EGFR) plays a crucial role in maintaining and restoring the corneal epithelium. Recent advances in understanding EGFR signaling and trafficking offer new strategies to overcome receptor desensitization and optimize receptor signaling for corneal health.
Article
Gastroenterology & Hepatology
Juhoon So, Minwook Kim, Seung-Hoon Lee, Sungjin Ko, Daniel A. Lee, Hyewon Park, Mizuki Azuma, Michael J. Parsons, David Prober, Donghun Shin
Summary: The differentiation of liver progenitor cells (LPCs) into hepatocytes is crucial for reducing inflammation and fibrosis in chronic liver diseases. Inhibition of the epidermal growth factor receptor (EGFR) signaling pathway promotes LPC-to-hepatocyte differentiation and may serve as a proregenerative therapeutic approach for patients with advanced liver disease. This study provides insights into the mechanisms underlying LPC-mediated liver regeneration and suggests the potential of EGFR inhibitors as a treatment option.
