Novel CYP2B6 Enzyme Variants in a Rwandese Population: Functional Characterization and Assessment of In Silico Prediction Tools

Bioactivation of chlorpyrifos by CYP2B6 variants

(2012) Alice L. Crane et al.   XENOBIOTICA

In Vitro Assessment of the Allelic Variants of Cytochrome P450

(2011) Masahiro Hiratsuka   Drug Metabolism and Pharmacokinetics

Performance of mutation pathogenicity prediction methods on missense variants

(2011) Janita Thusberg et al.   HUMAN MUTATION

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

(2011) C. Wyen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Analysis of clinically relevant substrates of CYP2B6 enzyme by computational methods

(2011) Rui-Juan Niu et al.   JOURNAL OF MOLECULAR MODELING

Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection

(2010) Y. Jamshidi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effect ofCYP2B6,ABCB1, andCYP3A5Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study

(2010) Heather J. Ribaudo et al.   JOURNAL OF INFECTIOUS DISEASES

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-A Resolution

(2010) S. C. Gay et al.   MOLECULAR PHARMACOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Automated inference of molecular mechanisms of disease from amino acid substitutions

(2009) B. Li et al.   BIOINFORMATICS

A Bioinformatics Approach for the Phenotype Prediction of Nonsynonymous Single Nucleotide Polymorphisms in Human Cytochromes P450

(2009) L.-L. Wang et al.   DRUG METABOLISM AND DISPOSITION

Functional annotations improve the predictive score of human disease-related mutations in proteins

(2009) Remo Calabrese et al.   HUMAN MUTATION

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

The Genetic Structure and History of Africans and African Americans

(2009) S. A. Tishkoff et al.   SCIENCE

CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme

(2008) Hongbing Wang et al.   CURRENT DRUG METABOLISM

Aberrant Splicing Caused by Single Nucleotide Polymorphism c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible for Decreased Expression and Activity of CYP2B6 in Liver

(2008) M. H. Hofmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo

(2008) T.-A. Nguyen et al.   MOLECULAR PHARMACOLOGY

Pharmacogenetics of Anti-HIV Drugs

(2007) A. Telenti et al.   Annual Review of Pharmacology and Toxicology