Deep sequencing of theLRRK2gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

(2011) Owen A Ross et al.   LANCET NEUROLOGY

Performance of Genotype Imputation for Rare Variants Identified in Exons and Flanking Regions of Genes

(2011) Li Li et al.   PLoS One

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

(2011) B. D. Looyenga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes

(2010) Erin L. Heinzen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study

(2010) Dalia Kasperavičiūtė et al.   BRAIN

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

In silico functional profiling of human disease-associated and polymorphic amino acid substitutions

(2010) Matthew Mort et al.   HUMAN MUTATION

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

(2010) Themistocles L. Assimes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease

(2010) Jan O. Aasly et al.   MOVEMENT DISORDERS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Statistical analysis strategies for association studies involving rare variants

(2010) Vikas Bansal et al.   NATURE REVIEWS GENETICS

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

(2010) Patrick Danoy et al.   PLoS Genetics

Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci

(2009) Charlotte Vignal et al.   ARTHRITIS AND RHEUMATISM

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

(2009) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors

(2009) Martin Preisig et al.   BMC Psychiatry

SNP detection for massively parallel whole-genome resequencing

(2009) R. Li et al.   GENOME RESEARCH

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population

(2009) Karen Nuytemans et al.   HUMAN MUTATION

LRRK2gene variation and its contribution to Parkinson disease

(2009) Coro Paisán-Ruiz   HUMAN MUTATION

LRRK2 variant associated with Alzheimer's disease

(2009) Yi Zhao et al.   NEUROBIOLOGY OF AGING

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide Linkage and Association Analyses to Identify Genes Influencing Adiponectin Levels: The GEMS Stud

(2009) Hua Ling et al.   Obesity

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Positive Selection in the Human Genome: From Genome Scans to Biological Significance

(2008) Joanna L. Kelley et al.   Annual Review of Genomics and Human Genetics

SOAP: short oligonucleotide alignment program

(2008) R. Li et al.   BIOINFORMATICS

The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome

(2008) Mathieu Firmann et al.   BMC Cardiovascular Disorders

Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)

(2008) J. Vestbo et al.   EUROPEAN RESPIRATORY JOURNAL

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Comprehensive analysis ofLRRK2in publicly available Parkinson's disease cases and neurologically normal controls

(2008) Coro Paisán-Ruíz et al.   HUMAN MUTATION

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Population-based linkage analysis of schizophrenia and bipolar case–control cohorts identifies a potential susceptibility locus on 19q13

(2008) C Francks et al.   MOLECULAR PSYCHIATRY

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

(2008) P Muglia et al.   MOLECULAR PSYCHIATRY

Genes mirror geography within Europe

(2008) John Novembre et al.   NATURE

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

(2008) Jaspal S Kooner et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

The LRRK2 Arg1628Pro variant is a risk factor for Parkinson’s disease in the Chinese population

(2008) Chin-Song Lu et al.   NEUROGENETICS

Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

(2007) Hao Li et al.   ARCHIVES OF NEUROLOGY