Article
Multidisciplinary Sciences
Su-Hyun Lee, Jihye Kim, Bokman Lim, Hwang-Jae Lee, Yun-Hee Kim
Summary: Wearable assistive robotics, such as the EX1, have shown promise in supplementing or replacing motor functions and improving mobility in individuals recovering from injury or with reduced mobility. In this study, long-term exercise with the EX1 was found to improve gait, physical function, and cardiopulmonary metabolic energy efficiency in elderly individuals. The experimental group who exercised with the EX1 showed greater improvements in spatiotemporal gait parameters, muscle strength, and reduced muscle effort during walking compared to the control group who did not use the EX1. These findings support the effectiveness of using the EX1 in physical activity and gait exercise for older adults.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Luca Prosperini, Valentina Tomassini, Letizia Castelli, Andrea Tacchino, Giampaolo Brichetto, Davide Cattaneo, Claudio Marcello Solaro
Summary: The study found that exergames have a moderate effect on improving balance dysfunction in neurological conditions. Higher frequency interventions were associated with larger effects, but overall intervention duration and session intensity did not affect the outcome. The beneficial effects of exergames may be maintained for at least 4 weeks after discontinuation, but further research is needed to explore this retention effect.
JOURNAL OF NEUROLOGY
(2021)
Article
Orthopedics
Sarah M. Schwab, Sarah Dugan, Michael A. Riley
Summary: Mobility and speech-language impairments in adults with neurological conditions do not manifest in isolated anatomical components, but are task-dependent and require interprofessional care for optimization. Despite the benefits of cotreatment between physical therapists and speech-language pathologists, there are still limitations in this collaboration. Enhanced cotreatment and collaboration between these disciplines can improve function and task-relevant conditions.
Article
Geriatrics & Gerontology
Serena Granziera, Andrea Alessandri, Anna Lazzaro, Daniela Zara, Alberto Scarpa
Summary: Non-pharmacological interventions, such as Nordic Walking and Walking, were compared in a randomized controlled trial for patients with Parkinson's disease. While both activities showed improvements in various symptoms, Nordic Walking did not demonstrate superiority over Walking in this study. Outdoor group activities at moderate intensity appear to be beneficial for both motor and non-motor symptoms in Parkinson's disease patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Clinical Neurology
Maria Grazia Maggio, Daniela De Bartolo, Rocco Salvatore Calabro, Irene Ciancarelli, Antonio Cerasa, Paolo Tonin, Fulvia Di Iulio, Stefano Paolucci, Gabriella Antonucci, Giovanni Morone, Marco Iosa
Summary: This article reviews the available software and devices for computerized cognitive training and rehabilitation interventions, as well as their feasibility and efficacy in both hospital and home settings. The study demonstrates that technology-based devices can be potential and valuable tools for remote cognitive rehabilitation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rehabilitation
Allison Miller, Ryan T. Pohlig, Tamara Wright, Hyosub E. Kim, Darcy S. Reisman
Summary: This study identified latent classes of survivors of chronic stroke using a mixture model and found significant differences in walking ability, psychosocial factors, environment, and cognition among these classes. The results indicated that real-world walking activity in survivors of stroke is influenced by multiple factors including walking ability, self-efficacy, cognitive function, and socioeconomic environment.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Chemistry, Multidisciplinary
Marianna Capecci, Nicolo Baldini, Francesca Campignoli, Lorenzo Pasquale Lombardo, Elisa Andrenelli, Maria Gabriella Ceravolo
Summary: This retrospective study evaluates the impact of COVID-19 on the clinical and functional evolution of 221 consecutively referred PD patients. The findings show that all primary endpoint measures worsened in 2020 compared to 2019, and the percentage of patients receiving neurologic visits or rehabilitation sessions reduced significantly. However, patients who received at least one cycle of rehabilitation sessions in 2020 maintained their independence level.
APPLIED SCIENCES-BASEL
(2023)
Article
Health Care Sciences & Services
Valentina Varalta, Paola Poiese, Serena Recchia, Barbara Montagnana, Cristina Fonte, Mirko Filippetti, Michele Tinazzi, Nicola Smania, Alessandro Picelli
Summary: This study investigated the effects of consecutive physiotherapy and cognitive rehabilitation on cognitive, motor, and psychological aspects in Parkinson's disease patients. Results showed that patients who received consecutive training performed better in functional mobility and memory tasks, supporting the hypothesis that consecutive physiotherapy plus cognitive rehabilitation may be more beneficial than physiotherapy alone.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Neurosciences
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Subramanian Mariappan, Subramanian Rashmi, Thiwanya Choeisoongnern, Phakkharawat Sittiprapaporn, Chaiyavat Chaiyasut
Summary: Parkinson's disease is a common neurological disorder characterized by motor and non-motor features, which is more prevalent in the elderly. Sleep disorders and cognitive disturbances are common characteristics of Parkinson's disease and have important prognostic value in predicting neurodegeneration and dementia. Understanding the relationship between sleep disorders, cognitive impairment, and Parkinson's disease can aid in the development of effective treatments.
Article
Clinical Neurology
Mercedes Paniagua-Monrobel, Isabel Escobio-Prieto, Eleonora Magni, Alejandro Galan-Mercant, David Lucena-Anton, Elena Pinero-Pinto, Carlos Luque-Moreno
Summary: Physical therapy is essential for functional recovery after a stroke. This study analyzed clinical history data of stroke patients who received physical therapy to identify a preferential patient profile for early treatment. The results indicate that younger patients with hemorrhagic stroke, particularly on the left side or bilateral, are more suitable for early physical therapy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Alexandra Balshi, Elena Taylor, Yishang Huang, Danielle Obando, Ashley Miles, Michael Comisac, Yujie Wang, Scott D. Newsome
Summary: This study investigated the prevalence of non-neurological autoantibodies and associated conditions in a large cohort of people with Stiff Person Syndrome Spectrum Disorders (SPSD), and found that autoimmune comorbidities were weakly associated with disease burden.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elle E. M. Scheijen, David M. Wilson
Summary: Neurological complications have a direct impact on the lives of hundreds of millions of people globally. Accumulation of genomic DNA damage and cellular responses can lead to apoptosis and neurodegenerative diseases. Individuals with pathogenic mutations in DNA damage response genes experience severe neuropathological manifestations. Understanding DNA repair mechanisms is crucial for treating neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Monica Elena Iosub, Dorina Ianc, Elena Sirbu, Doriana Ciobanu, Liviu Lazar
Summary: This article compared the effects of Vojta therapy and conservative physical therapy versus physical therapy only for lumbar disc herniation. The results showed that both interventions significantly reduced pain and disability, and improved mobility, muscle strength, and health-related quality of life.
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, Research & Experimental
Yuan-yi Wang, Jin Cheng, Ya-dong Liu, Yi-peng Wang, Qi-wei Yang, Nan Zhou
Summary: Neurological disorders have a significant impact on patients' quality of life. Traditional surgical and medical approaches have limited effectiveness, leading to the widespread use of neurorehabilitation protocols. However, neural regeneration is often limited, necessitating the introduction of regenerative rehabilitation. Exosomes, released by stimulated cells, play a crucial role in neurorehabilitation by promoting neural regeneration. Combining exosome therapy with neurorehabilitation approaches can effectively repair neural tissue damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Orthopedics
Lucas Rodrigues Nascimento, Willian Assis do Carmo, Gabriela Pinto de Oliveira, Fernando Zanela da Silva Areas, Fernanda Moura Vargas Dias
Summary: A systematic review with meta-analyses of randomized clinical trials found that the addition of tDCS to walking training in patients with Parkinson's disease did not provide clinically significant benefits in walking outcomes such as speed, step length, and cadence. There was no evidence to suggest an effect of tDCS on freezing of gait, falls, or social participation in these patients.
JOURNAL OF PHYSIOTHERAPY
(2021)
Article
Neurosciences
Mana Biabani, Michael Farrell, Maryam Zoghi, Gary Egan, Shapour Jaberzadeh
NEUROSCIENCE LETTERS
(2018)
Article
Anesthesiology
Leonie J. Cole, Kim L. Bennell, Yasmin Ahamed, Christina Bryant, Francis Keefe, G. Lorimer Moseley, Paul Hodges, Michael J. Farrell
Article
Multidisciplinary Sciences
Pascal Saker, Michael J. Farrell, Gary F. Egan, Michael J. McKinley, Derek A. Denton
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Neurosciences
Mana Biabani, Michael Farrell, Maryam Zoghi, Gary Egan, Shapour Jaberzadeh
REVIEWS IN THE NEUROSCIENCES
(2018)
Article
Neurosciences
Tara G. Bautista, Jennifer Leech, Stuart B. Mazzone, Michael J. Farrell
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Review
Clinical Neurology
Simon Sung, Nirosen Vijiaratnam, Daniela Wan Chi Chan, Michael Farrell, Andrew H. Evans
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2018)
Article
Pharmacology & Pharmacy
Stuart B. Mazzone, Michael J. Farrell
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Respiratory System
Ayaka Ando, Stuart B. Mazzone, Michael J. Farrell
EUROPEAN RESPIRATORY JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Michael J. Farrell, Stuart B. Mazzone
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Pascal Saker, Steve Carey, Marcus Grohmann, Michael J. Farrell, Philip J. Ryan, Gary F. Egan, Michael J. McKinley, Derek A. Denton
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
Michael J. Farrell, Tara G. Bautista, Emma Liang, Damian Azzollini, Gary F. Egan, Stuart B. Mazzone
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Review
Neurosciences
Robert Behrens, Alice E. McGovern, Michael J. Farrell, Aung Aung Kywe Moe, Stuart B. Mazzone
Summary: Airway afferents monitor local chemical and physical environments in airway and lungs, regulating neural circuits involved in respiratory control, sensory encoding, and cognitive processing. Recent research highlights the central wiring of airway afferent circuits in the brainstem and brain, providing new insights into airway sensory processing. Describing the molecular diversity of airway afferents may shape future research on central connectivity of these pathways.
NEUROSCIENCE LETTERS
(2021)
Review
Anesthesiology
Malcolm N. Hogg, Anthony Kavanagh, Michael J. Farrell, Anne L. J. Burke
Summary: The study found that persistent pain services in Australia have increased in both adult and pediatric fields, but there are still some long wait times. Although clinical activity has increased, the number of medical staff has not increased, indicating that clinics are operating differently. Privately funded clinics perform more procedures than publicly funded services.
Article
Neurosciences
Stuart B. Mazzone, Tara G. Bautista, Anthony J. M. Verberne, Matthew W. Trewella, Michael J. Farrell, Alice E. McGovern
JOURNAL OF NEUROSCIENCE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chetan Julka, Richard Bassed, Matthew Dimmock, Michael Farrell, Chris O'Donnell, Linda Iles
JOURNAL OF FORENSIC RADIOLOGY AND IMAGING
(2019)
Article
Neurosciences
John J. Buchanan, Alberto Cordova
Summary: Research has shown that spontaneous visual coupling supports frequency entrainment, phase attraction, and intermittent interpersonal coordination during the switch from a novision (NV) to vision (V) context among co-actors. The experiments demonstrate that similar self-paced frequencies result from same amplitude movements, while different amplitudes lead to disparate frequencies. In experiment 1, co-actors were instructed to maintain amplitude without explicit instructions for coordination, which limited frequency and phase entrainment in the V context. In experiment 2, co-actors were instructed to maintain amplitude and intentionally coordinate together, resulting in significant frequency modulations and the production of various stable relative phase patterns.
HUMAN MOVEMENT SCIENCE
(2024)