Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia

Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications

(2014) Ximena Paredes-Gonzalez et al.   AAPS Journal

Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia

(2014) Yogesh K. Chutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frataxin Deficiency Leads to Defects in Expression of Antioxidants and Nrf2 Expression in Dorsal Root Ganglia of the Friedreich's Ataxia YG8R Mouse Model

(2013) Yuxi Shan et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

(2013) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Dimethyl fumarate regulates histone deacetylase expression in astrocytes

(2013) Sergey Kalinin et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurodegeneration, Mitochondrial Dysfunction, and Oxidative Stress

(2013) Emilio L. Streck et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation

(2012) Ying Huang et al.   JOURNAL OF NUTRITION

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Thioredoxin Reductase Deficiency Potentiates Oxidative Stress, Mitochondrial Dysfunction and Cell Death in Dopaminergic Cells

(2012) Pamela Lopert et al.   PLoS One

Structure–Function Analysis of Friedreich’s Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe–S Assembly Complex

(2011) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

HSC20 interacts with frataxin and is involved in iron–sulfur cluster biogenesis and iron homeostasis

(2011) Yuxi Shan et al.   HUMAN MOLECULAR GENETICS

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

(2011) Chiranjeevi Sandi et al.   NEUROBIOLOGY OF DISEASE

Respiration-dependent H2O2Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System

(2010) Derek A. Drechsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood cells from Friedreich ataxia patients harbor frataxin deficiency without a loss of mitochondrial function

(2010) Mary A. Selak et al.   MITOCHONDRION

A rapid, noninvasive immunoassay for frataxin: Utility in assessment of Friedreich ataxia

(2010) Eric C. Deutsch et al.   MOLECULAR GENETICS AND METABOLISM

Measuring the rate of progression in Friedreich ataxia: Implications for clinical trial design

(2010) Lisa S. Friedman et al.   MOVEMENT DISORDERS

Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

(2010) Siwang Yu et al.   PLoS One

The dorsal root ganglion in Friedreich’s ataxia

(2009) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

Frataxin deficiency induces Schwann cell inflammation and death

(2009) Chunye Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells

(2009) Se-Jin Kim et al.   HEARING RESEARCH

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia

(2009) Vincent Paupe et al.   PLoS One

Epigenetic Silencing in Friedreich Ataxia Is Associated with Depletion of CTCF (CCCTC-Binding Factor) and Antisense Transcription

(2009) Irene De Biase et al.   PLoS One

The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation

(2008) Andrew G. Cox et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation andS-Nitrosylation of Cysteine Residues

(2008) Seyed Isaac Hashemy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lateral-flow immunoassay for the frataxin protein in Friedreich’s ataxia patients and carriers

(2008) John H. Willis et al.   MOLECULAR GENETICS AND METABOLISM

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH