The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

(2015) Deliang Guo et al.   CURRENT PHARMACEUTICAL DESIGN

Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations

(2014) Eivind Lund et al.   NUCLEIC ACIDS RESEARCH

Nuclear envelope-related lipodystrophies

(2014) A.C. Guénantin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Partners and post-translational modifications of nuclear lamins

(2013) Dan N. Simon et al.   CHROMOSOMA

Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes

(2013) E. Lund et al.   GENOME RESEARCH

Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes

(2013) Anja R. Oldenburg et al.   HUMAN MOLECULAR GENETICS

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

(2013) Baohua Liu et al.   Nature Communications

Nuclear lamins

(2013) Eivind Lund et al.   Nucleus

Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria

(2012) Baohua Liu et al.   Cell Metabolism

SREBPs: regulators of cholesterol/lipids as therapeutic targets in metabolic disorders, cancers and viral diseases

(2012) Amy K Walker et al.   Clinical Lipidology

Lamin misexpression upregulates three distinct ubiquitin ligase systems that degrade ATR kinase in HeLa cells

(2012) Bhattiprolu Muralikrishna et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Ubiquitin ligase RNF123 Mediates Degradation of Heterochromatin Protein 1α and β in Lamin A/C Knock-Down Cells

(2012) Pankaj Chaturvedi et al.   PLoS One

LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue

(2011) Véronique Béréziat et al.   AMERICAN JOURNAL OF PATHOLOGY

Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide

(2011) Changiz Taghibiglou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins

(2011) Isabelle Duband-Goulet et al.   EXPERIMENTAL CELL RESEARCH

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells

(2011) Thorsten Kolb et al.   Nucleus

Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence

(2010) You-Mie Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear envelope in genome organization, expression and stability

(2010) Karim Mekhail et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lamin A Rod Domain Mutants Target Heterochromatin Protein 1α and β for Proteasomal Degradation by Activation of F-Box Protein, FBXW10

(2010) Pankaj Chaturvedi et al.   PLoS One

Nuclear Lamins

(2010) T. Dechat et al.   Cold Spring Harbor Perspectives in Biology

The Posttranslational Processing of Prelamin A and Disease

(2009) Brandon S.J. Davies et al.   Annual Review of Genomics and Human Genetics

A Phosphorylation Cascade Controls the Degradation of Active SREBP1

(2009) Maria T. Bengoechea-Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope

(2008) José María González et al.   JOURNAL OF CELL BIOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

(2008) Sophie Rome et al.   PHYSIOLOGICAL GENOMICS

SREBPs: the crossroads of physiological and pathological lipid homeostasis

(2008) Rajendra Raghow et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes

(2008) Brian D. Reed et al.   PLoS Genetics