Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway

FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption

(2012) Inna V. Nechipurenko et al.   JOURNAL OF CELL BIOLOGY

TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction

(2012) Jay Penney et al.   NEURON

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

(2011) E E Vincent et al.   BRITISH JOURNAL OF CANCER

Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex

(2011) Peter Tsai et al.   CURRENT OPINION IN NEUROLOGY

TSC1/TSC2 signaling in the CNS

(2011) Juliette M. Han et al.   FEBS LETTERS

Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex

(2011) S. Anderl et al.   HUMAN MOLECULAR GENETICS

S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development

(2011) Ling Cheng et al.   JOURNAL OF CELL BIOLOGY

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Increased Levels of Anxiety-related Behaviors in a Tsc2 Dominant Negative Transgenic Mouse Model of Tuberous Sclerosis

(2010) Dan Ehninger et al.   BEHAVIOR GENETICS

Tuberous sclerosis complex: a brave new world?

(2010) Kevin C Ess   CURRENT OPINION IN NEUROLOGY

The Late Endosome is Essential for mTORC1 Signaling

(2010) Rory J. Flinn et al.   MOLECULAR BIOLOGY OF THE CELL

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

(2010) Dan Ehninger et al.   TRENDS IN MOLECULAR MEDICINE

Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

(2010) Lutz Kockel et al.   PLoS Genetics

Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors

(2009) J. Huang et al.   CANCER RESEARCH

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling

(2009) Y. P. Wairkar et al.   JOURNAL OF NEUROSCIENCE

Rab3 Dynamically Controls Protein Composition at Active Zones

(2009) Ethan R. Graf et al.   NEURON

Akt Phosphorylates Both Tsc1 and Tsc2 in Drosophila, but Neither Phosphorylation Is Required for Normal Animal Growth

(2009) Sibylle Schleich et al.   PLoS One

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synaptic Defects in a Drosophila Model of Congenital Muscular Dystrophy

(2008) Y. P. Wairkar et al.   JOURNAL OF NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE