Functional characterization of SIM1-associated enhancers

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features

(2013) Amélie Bonnefond et al.   JOURNAL OF CLINICAL INVESTIGATION

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Dissecting genomic regulatory elements in vivo

(2012) Vanja Haberle et al.   NATURE BIOTECHNOLOGY

ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions

(2012) Terrence S. Furey   NATURE REVIEWS GENETICS

Genotype–phenotype correlation in interstitial 6q deletions: a report of 12 new cases

(2012) Jill A. Rosenfeld et al.   NEUROGENETICS

Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure

(2012) Dong Xi et al.   PLoS One

Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh that Controls the Generation of Interneuron Progenitors

(2011) Pierre Flandin et al.   NEURON

6q1 monosomy: a distinctive syndrome

(2010) Catherine Turleau et al.   CLINICAL GENETICS

Postnatal Sim1 Deficiency Causes Hyperphagic Obesity and Reduced Mc4r and Oxytocin Expression

(2010) K. P. Tolson et al.   JOURNAL OF NEUROSCIENCE

A genomic atlas of mouse hypothalamic development

(2010) Tomomi Shimogori et al.   NATURE NEUROSCIENCE

Analysis of the SIM1 Contribution to Polygenic Obesity in the French Population

(2010) Maya Ghoussaini et al.   Obesity

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

A systematic approach to identify functional motifs within vertebrate developmental enhancers

(2009) Qiang Li et al.   DEVELOPMENTAL BIOLOGY

Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians

(2009) M. Traurig et al.   DIABETES

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Detailed phenotype–genotype study in five patients with chromosome 6q16 deletion: narrowing the critical region for Prader–Willi-like phenotype

(2008) Maria Clara Bonaglia et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study

(2008) M. A. Calton et al.   HUMAN MOLECULAR GENETICS

Shadow Enhancers as a Source of Evolutionary Novelty

(2008) J.-W. Hong et al.   SCIENCE