Evidence for dysregulation of genome-wide recombination in oocytes with nondisjoined chromosomes 21

RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis

(2013) April Reynolds et al.   NATURE GENETICS

Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner

(2012) Simone de Jong et al.   BMC GENOMICS

Variation in Human Recombination Rates and Its Genetic Determinants

(2011) Adi Fledel-Alon et al.   PLoS One

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations

(2011) I. L. Berg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

(2010) Samantha E. Parker et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Fine-scale recombination rate differences between sexes, populations and individuals

(2010) Augustine Kong et al.   NATURE

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

(2010) Ingrid L Berg et al.   NATURE GENETICS

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

(2010) F. Baudat et al.   SCIENCE

Genetic Analysis of Variation in Human Meiotic Recombination

(2009) Reshmi Chowdhury et al.   PLoS Genetics

Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects

(2008) Emily Graves Allen et al.   HUMAN GENETICS

High-Resolution Mapping of Crossovers Reveals Extensive Variation in Fine-Scale Recombination Patterns Among Humans

(2008) G. Coop et al.   SCIENCE

Sequence Variants in the RNF212 Gene Associate with Genome-Wide Recombination Rate

(2008) A. Kong et al.   SCIENCE

New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

(2008) Tiffany Renee Oliver et al.   PLoS Genetics