PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Conditional Expression of Parkinson's Disease-Related Mutant  -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

(2012) X. Lin et al.   JOURNAL OF NEUROSCIENCE

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Impaired dopaminergic neuron development and locomotor function in zebrafish with loss ofpink1function

(2010) Yanwei Xi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Proteasome inhibition in medaka brain induces the features of Parkinson’s disease

(2010) Hideaki Matsui et al.   JOURNAL OF NEUROCHEMISTRY

Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson’s disease-like phenotypes in medaka fish

(2010) Hideaki Matsui et al.   JOURNAL OF NEUROCHEMISTRY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects

(2010) Taku Amo et al.   NEUROBIOLOGY OF DISEASE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

(2010) Mareike E. Fett et al.   PLoS One

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)

(2009) L. Flinn et al.   BRAIN

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

(2009) A. K. Berger et al.   HUMAN MOLECULAR GENETICS

Impaired dopamine release and synaptic plasticity in the striatum ofParkin−/− mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish

(2009) Hideaki Matsui et al.   NEUROSCIENCE RESEARCH

Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement

(2009) Hideaki Matsui et al.   NEUROSCIENCE RESEARCH

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

Correct Assay of Complex I Activity in Human Skin Fibroblasts by Timely Addition of Rotenone

(2008) L. E. A. de Wit et al.   CLINICAL CHEMISTRY

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

(2008) O. Anichtchik et al.   JOURNAL OF NEUROSCIENCE

L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner

(2008) Yasuhiro Moriwaki et al.   NEUROSCIENCE RESEARCH

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

(2008) H. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA