Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/β-catenin signaling

Mammalian sex determination—insights from humans and mice

(2012) Stefanie Eggers et al.   CHROMOSOME RESEARCH

Changing the game with whole exome sequencing

(2011) H Ostrer   CLINICAL GENETICS

Rapidly screening variants of uncertain significance in the MAP3K1 gene for phenotypic effects

(2011) J Loke et al.   CLINICAL GENETICS

Wnt Signaling in Ovarian Development Inhibits Sf1 Activation ofSox9via theTescoEnhancer

(2011) Pascal Bernard et al.   ENDOCRINOLOGY

Failure of SOX9 Regulation in 46XY Disorders of Sex Development with SRY, SOX9 and SF1 Mutations

(2011) Kevin C. Knower et al.   PLoS One

Minor Abnormalities of Testis Development in Mice Lacking the Gene Encoding the MAPK Signalling Component, MAP3K1

(2011) Nick Warr et al.   PLoS One

Mutations in MAP3K1 Cause 46,XY Disorders of Sex Development and Implicate a Common Signal Transduction Pathway in Human Testis Determination

(2010) Alexander Pearlman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway

(2010) Ser Sue Ng et al.   BIOLOGICAL CHEMISTRY

The Transcriptional Activity of Sox9 in Chondrocytes Is Regulated by RhoA Signaling and Actin Polymerization

(2009) D. Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Mixed Signals: Development of the Testis

(2009) Jonah Cool et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

(2009) Debora Bogani et al.   PLOS BIOLOGY

Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

(2008) Danielle M. Maatouk et al.   HUMAN MOLECULAR GENETICS

Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus

(2008) Lilia Topol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE