A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice

(2012) Anna E Beaudin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Maternal and infant gene-folate interactions and the risk of neural tube defects

(2012) Analee J. Etheredge et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects

(2012) Faith Pangilinan et al.   BMC Medical Genetics

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects

(2012) Dingxu Gong et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

(2012) J. Momb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1 metabolism and CVD outcomes in older adults

(2011) Helene McNulty et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Mthfs is an Essential Gene in Mice and a Component of the Purinosome

(2011) Martha S. Field et al.   Frontiers in Genetics

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline

(2010) Jian Yan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

MTHFR c.1793G>A polymorphism is associated with congenital cardiac disease in a Chinese population

(2010) Jing Xu et al.   CARDIOLOGY IN THE YOUNG

Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects

(2010) Frans A Hol et al.   CLINICAL GENETICS

TheMTHFD1c.1958 G>A polymorphism and recurrent spontaneous abortions

(2010) Tania O. Crişan et al.   Journal of Maternal-Fetal & Neonatal Medicine

Steatosis in Mice Is Associated with Gender, Folate Intake, and Expression of Genes of One-Carbon Metabolism

(2010) Karen E. Christensen et al.   JOURNAL OF NUTRITION

Pregnancy Alters the Proliferation and Apoptosis of Mouse Splenic Erythroid Lineage Cells and Leukocytes1

(2009) Michelle T. Norton et al.   BIOLOGY OF REPRODUCTION

Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice

(2009) Laura Pickell et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

(2009) Gary M Shaw et al.   BMC Medical Genetics

Analysis of the MTHFD1 promoter and risk of neural tube defects

(2009) Nicola Carroll et al.   HUMAN GENETICS

Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos

(2009) Schuyler T. Pike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Variants in Phosphatidylethanolamine N-methyltransferase and Methylenetetrahydrofolate Dehydrogenase Influence Biomarkers of Choline Metabolism When Folate Intake Is Restricted

(2009) Alexandre Ivanov et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

(2009) Donald D. Anderson et al.   PLoS One

One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency

(2008) Denise L.F. Furness et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

(2008) Karen E. Christensen et al.   HUMAN MUTATION

Mthfd1Is an Essential Gene in Mice and Alters Biomarkers of Impaired One-carbon Metabolism

(2008) Amanda J. MacFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women

(2007) Christian M. Abratte et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY