The CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression

Genetic disruption ofPtenin a novel mouse model of tomaculous neuropathy

(2012) Sandra Goebbels et al.   EMBO Molecular Medicine

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

(2012) D. L. Sherman et al.   JOURNAL OF NEUROSCIENCE

ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination

(2012) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling

(2012) Steve Jean et al.   MOLECULAR BIOLOGY OF THE CELL

Myotubularin phosphoinositide phosphatases: cellular functions and disease pathophysiology

(2012) Karim Hnia et al.   TRENDS IN MOLECULAR MEDICINE

Myotubularin Regulates Akt-dependent Survival Signaling via Phosphatidylinositol 3-Phosphate

(2011) Gina L. Razidlo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal Targeting of the Phosphoinositide 3-Phosphatase MTMR2 Is Regulated by an N-terminal Phosphorylation Site

(2011) Norah E. Franklin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Functions for ERK/MAPK Signaling during PNS Development

(2011) Jason M. Newbern et al.   NEURON

Phosphatidylinositol-3,5-Bisphosphate: No Longer the Poor PIP2

(2011) Cheuk Y. Ho et al.   TRAFFIC

Molecular mechanisms regulating myelination in the peripheral nervous system

(2011) Jorge A. Pereira et al.   TRENDS IN NEUROSCIENCES

Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies

(2011) Ilaria Vaccari et al.   PLoS Genetics

Genetic and clinical aspects of Charcot-Marie-Tooth's disease

(2010) H. Skre   CLINICAL GENETICS

Update on Charcot-Marie-Tooth Disease

(2010) Ágnes Patzkó et al.   Current Neurology and Neuroscience Reports

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

(2010) Shin-ichiro Yoshimura et al.   JOURNAL OF CELL BIOLOGY

DrosophilaMtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions

(2010) Michaella Velichkova et al.   JOURNAL OF CELL BIOLOGY

The Phosphoinositide 3-Phosphatase MTMR2 Interacts with PSD-95 and Maintains Excitatory Synapses by Modulating Endosomal Traffic

(2010) H. W. Lee et al.   JOURNAL OF NEUROSCIENCE

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination

(2010) L. Cotter et al.   SCIENCE

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

Rethinking phosphatidylinositol 3-monophosphate

(2009) Marco Falasca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling

(2009) Philipp Berger et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dlg1, Sec8, and Mtmr2 Regulate Membrane Homeostasis in Schwann Cell Myelination

(2009) A. Bolis et al.   JOURNAL OF NEUROSCIENCE

Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

(2009) Heather J. McCrea et al.   PHYSIOLOGY

Phosphoinositides and the endocytic pathway

(2008) Michael J. Clague et al.   EXPERIMENTAL CELL RESEARCH

Molecular mechanisms of inherited demyelinating neuropathies

(2008) Steven S. Scherer et al.   GLIA

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice

(2008) F. L. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA