A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

(2011) Shane McManus et al.   EMBO JOURNAL

Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action

(2011) Michael Q. Kemp et al.   HUMAN MOLECULAR GENETICS

Role of PTIP in Class Switch Recombination and Long-Range Chromatin Interactions at the Immunoglobulin Heavy Chain Locus

(2011) K. R. Schwab et al.   MOLECULAR AND CELLULAR BIOLOGY

Expanded CAG/CTG Repeat DNA Induces a Checkpoint Response That Impacts Cell Proliferation in Saccharomyces cerevisiae

(2011) Rangapriya Sundararajan et al.   PLoS Genetics

Mutant huntingtin impairs Ku70-mediated DNA repair

(2010) Yasushi Enokido et al.   JOURNAL OF CELL BIOLOGY

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy

(2010) Natalia B. Nedelsky et al.   NEURON

PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination

(2010) J. A. Daniel et al.   SCIENCE

Polyglutamine Diseases: Where does Toxicity Come from? What is Toxicity? Where are We Going?

(2010) T. Takahashi et al.   Journal of Molecular Cell Biology

Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways

(2009) M. Fang et al.   DEVELOPMENT

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

(2009) Heather L. Montie et al.   HUMAN MOLECULAR GENETICS

PTIP Regulates 53BP1 and SMC1 at the DNA Damage Sites

(2009) Jiaxue Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of Pax2 Transactivation Domain Interaction Protein (PTIP) at Sites of DNA Breaks via RNF8-dependent Pathway Is Required for Cell Survival after DNA Damage

(2009) Zihua Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spinal and bulbar muscular atrophy: a motoneuron or muscle disease?

(2008) C JORDAN et al.   CURRENT OPINION IN PHARMACOLOGY

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

(2008) Jennifer Illuzzi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rad50 Is Dispensable for the Maintenance and Viability of Postmitotic Tissues

(2008) C. A. Adelman et al.   MOLECULAR AND CELLULAR BIOLOGY

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

(2008) Janghoo Lim et al.   NATURE