Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome

Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center

(2011) Claudia Compagnucci et al.   GENESIS

Molecular and phenotypic aspects ofCHD7mutation in CHARGE syndrome

(2010) Gabriel E. Zentner et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Diverse FGF receptor signaling controls astrocyte specification and proliferation

(2010) Kyungjun Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear

(2010) E. A. Hurd et al.   DEVELOPMENT

Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates

(2010) E. Maier et al.   DEVELOPMENT

Neuronal Regulation of the Spatial Patterning of Neurogenesis

(2010) Rosa Gonzalez-Quevedo et al.   DEVELOPMENTAL CELL

Disruption of the Single Copy Gonadotropin-Releasing Hormone Receptor in Mice by Gene Trap: Severe Reduction of Reproductive Organs and Functions in Developing and Adult Mice

(2010) Sheng Wu et al.   ENDOCRINOLOGY

Dynamic roles of FGF-2 and Anosmin-1 in the migration of neuronal precursors from the subventricular zone during pre- and postnatal development

(2010) Diego García-González et al.   EXPERIMENTAL NEUROLOGY

Gonadotropin-releasing hormone (GnRH) neuron migration: Initiation, maintenance and cessation as critical steps to ensure normal reproductive function

(2010) Margaret E. Wierman et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination

(2010) Holly S. Cate et al.   JOURNAL OF NEUROCHEMISTRY

Mouse models to study the central regulation of puberty

(2010) William H. Colledge et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chromatin remodelling during development

(2010) Lena Ho et al.   NATURE

CHD7 cooperates with PBAF to control multipotent neural crest formation

(2010) Ruchi Bajpai et al.   NATURE

CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene Expression

(2010) Michael P. Schnetz et al.   PLoS Genetics

CHD7mutations in patients initially diagnosed with Kallmann syndrome - the clinical overlap with CHARGE syndrome

(2009) MCJ Jongmans et al.   CLINICAL GENETICS

Study of smell and reproductive organs in a mouse model for CHARGE syndrome

(2009) Jorieke EH Bergman et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome

(2009) W.S. Layman et al.   HUMAN MOLECULAR GENETICS

Otx2 Induction of the Gonadotropin-releasing Hormone Promoter Is Modulated by Direct Interactions with Grg Co-repressors

(2009) Rachel Larder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterozygous Orthodenticle Homeobox 2 Mutations Are Associated with Variable Pituitary Phenotype

(2009) Sumito Dateki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differential Regulation of Gonadotropin-Releasing Hormone Neuron Activity and Membrane Properties by Acutely Applied Estradiol: Dependence on Dose and Estrogen Receptor Subtype

(2009) Z. Chu et al.   JOURNAL OF NEUROSCIENCE

The hypothalamic GnRH pulse generator: multiple regulatory mechanisms

(2009) Lazar Z. Krsmanovic et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mutations in CHD7, Encoding a Chromatin-Remodeling Protein, Cause Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome

(2008) Hyung-Goo Kim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

(2008) D. Omodei et al.   DEVELOPMENT

Fibroblast Growth Factor 8 Signaling through Fibroblast Growth Factor Receptor 1 Is Required for the Emergence of Gonadotropin-Releasing Hormone Neurons

(2008) Wilson C. J. Chung et al.   ENDOCRINOLOGY

The Gonadotropin-Releasing Hormone (GnRH) Neuronal Population Is Normal in Size and Distribution in GnRH-Deficient and GnRH Receptor-Mutant Hypogonadal Mice

(2008) John C. Gill et al.   ENDOCRINOLOGY

Novel heterozygousOTX2mutations and whole gene deletions in anophthalmia, microphthalmia and coloboma

(2008) Alexander Wyatt et al.   HUMAN MUTATION

OTX2Mutation in a Patient with Anophthalmia, Short Stature, and Partial Growth Hormone Deficiency: Functional Studies Using theIRBP,HESX1, andPOU1F1Promoters

(2008) Sumito Dateki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice

(2008) John Falardeau et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivoevaluation andin vitrometabolism of leuprolide in mice-mass spectrometry-based biomarker measurement for efficacy and toxicity

(2008) Zacharias D. Sofianos et al.   JOURNAL OF MASS SPECTROMETRY

Noggin Expands Neural Stem Cells in the Adult Hippocampus

(2008) M. A. Bonaguidi et al.   JOURNAL OF NEUROSCIENCE

Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells

(2008) D. Colak et al.   JOURNAL OF NEUROSCIENCE

Drosophila Kismet Regulates Histone H3 Lysine 27 Methylation and Early Elongation by RNA Polymerase II

(2008) Shrividhya Srinivasan et al.   PLoS Genetics

Endocrine and Radiological Studies in Patients with Molecularly Confirmed CHARGE Syndrome

(2007) Yumi Asakura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM