Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl− cotransport activity

(2010) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule

(2010) Nis B. Pedersen et al.   KIDNEY INTERNATIONAL

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

(2009) Akihito Ohta et al.   HUMAN MOLECULAR GENETICS

Regulation of ROMK Channel and K+Homeostasis by Kidney-specific WNK1 Kinase

(2009) Zhen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

(2008) Eric Delpire et al.   BIOCHEMICAL JOURNAL

Aldosterone, but not Increased Na+Influx or NF-κB Activation, Increases Kidney-specific WNK1 Gene Expression in Renal Collecting Duct Cells

(2008) M. Vinciguerra   HORMONE AND METABOLIC RESEARCH

Deletion of WNK1 First Intron Results in Misregulation of Both Isoforms in Renal and Extrarenal Tissues

(2008) Céline Delaloy et al.   HYPERTENSION

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE