Global patterns of genetic diversity and signals of natural selection for human ADME genes

Association of theSLC22A1,SLC22A2, andSLC22A3genes encoding organic cation transporters with diabetic nephropathy and hypertension

(2010) Riitta Sallinen et al.   ANNALS OF MEDICINE

Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy

(2010) Eliecer Coto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium

(2010) L. E. Kelemen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

ABCG2 Polymorphism Is Associated With the Low-Density Lipoprotein Cholesterol Response to Rosuvastatin

(2010) B Tomlinson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

(2010) D. F. Carr et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Genetic Variation in Metabolizing Enzyme and Transporter Genes: Comprehensive Assessment in 3 Major East Asian Subpopulations With Comparison to Caucasians and Africans

(2010) Michael Man et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements

(2010) Kendra A Ross et al.   JOURNAL OF HUMAN GENETICS

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Target-enrichment strategies for next-generation sequencing

(2010) Lira Mamanova et al.   NATURE METHODS

Allele-Specific Down-Regulation of RPTOR Expression Induced by Retinoids Contributes to Climate Adaptations

(2010) Chang Sun et al.   PLoS Genetics

Analysis of glutathione S-transferase Pi isoform (GSTP1) single-nucleotide polymorphisms and macular telangiectasia type 2

(2010) Joshua A. Szental et al.   INTERNATIONAL OPHTHALMOLOGY

CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients

(2009) Awewura Kwara et al.   AIDS

Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma

(2009) Hee Nam Kim et al.   AMERICAN JOURNAL OF HEMATOLOGY

The global pattern of gene identity variation reveals a history of long-range migrations, bottlenecks, and local mate exchange: Implications for biological race

(2009) Keith L. Hunley et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Genome wide signatures of positive selection: The comparison of independent samples and the identification of regions associated to traits

(2009) William Barendse et al.   BMC GENOMICS

Association of ABCB1 gene polymorphisms with plasma lipid and apolipoprotein concentrations in the STANISLAS cohort

(2009) Elise Jeannesson et al.   CLINICA CHIMICA ACTA

Clinical Relevance of a Pharmacogenetic Approach Using Multiple Candidate Genes to Predict Response and Resistance to Imatinib Therapy in Chronic Myeloid Leukemia

(2009) D. H. Kim et al.   CLINICAL CANCER RESEARCH

The Increasing Complexity of Mercaptopurine Pharmacogenomics

(2009) S Marsh et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Vitro Glucuronidation of Fenofibric Acid by Human UDP-Glucuronosyltransferases and Liver Microsomes

(2009) J. Tojcic et al.   DRUG METABOLISM AND DISPOSITION

Identification of New CYP2C19 Variants Exhibiting Decreased Enzyme Activity in the Metabolism of S-Mephenytoin and Omeprazole

(2009) S.-J. Lee et al.   DRUG METABOLISM AND DISPOSITION

Polymorphism of human cytochrome P450 enzymes and its clinical impact

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Molecular Population Genetics of Human CYP3A Locus: Signatures of Positive Selection and Implications for Evolutionary Environmental Medicine

(2009) Xiaoping Chen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: Is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?

(2009) José AG Agúndez et al.   Expert Opinion on Drug Metabolism & Toxicology

Signals of recent positive selection in a worldwide sample of human populations

(2009) J. K. Pickrell et al.   GENOME RESEARCH

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

(2009) Leslie Z. Benet   MOLECULAR PHARMACEUTICS

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

SLCO1B1Variants and Statin-Induced Myopathy

(2009) Georgirene D. Vladutiu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetic variation at CYP2C9, CYP2C19, and CYP2D6 at global and microgeographic scales

(2009) Johanna Sistonen et al.   Pharmacogenetics and Genomics

Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression and Promoter Activity Predict Variation

(2009) Stephanie E. Hesselson et al.   PLoS One

Genetic Variation and Recent Positive Selection in Worldwide Human Populations: Evidence from Nearly 1 Million SNPs

(2009) David López Herráez et al.   PLoS One

Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes

(2009) M. Karaźniewicz-łada et al.   XENOBIOTICA

Fine-Scale Variation and Genetic Determinants of Alternative Splicing across Individuals

(2009) Jasmin Coulombe-Huntington et al.   PLoS Genetics

The Role of Geography in Human Adaptation

(2009) Graham Coop et al.   PLoS Genetics

Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia

(2008) Kazuma Kiyotani et al.   CANCER SCIENCE

Unraveling Ambiguous NAT2 Genotyping Data

(2008) J. A. G. Agundez et al.   CLINICAL CHEMISTRY

Developmental Changes in Human Liver CYP2D6 Expression

(2008) J. C. Stevens et al.   DRUG METABOLISM AND DISPOSITION

Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease

(2008) Silvia Sookoian et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7

(2008) Huan Qiu et al.   Pharmacogenetics and Genomics

Multiple Advantageous Amino Acid Variants in the NAT2 Gene in Human Populations

(2008) Francesca Luca et al.   PLoS One

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

(2008) J. Z. Li et al.   SCIENCE

Global analysis of genetic variation in SLCO1B1

(2007) Marja K Pasanen et al.   PHARMACOGENOMICS