Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

(2009) Viviana Cordeddu et al.   NATURE GENETICS

Costello syndrome associated with novel germlineHRAS mutations: An attenuated phenotype?

(2008) Karen W. Gripp et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

(2008) Alexander Eberth et al.   BIOCHEMICAL JOURNAL

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP interaction

(2008) Lothar Gremer et al.   BIOLOGICAL CHEMISTRY

Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II

(2008) Benjamin Stieglitz et al.   EMBO JOURNAL

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

(2008) Yoko Aoki et al.   HUMAN MUTATION

OncogenicHRASmutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome

(2008) Georg Rosenberger et al.   HUMAN MUTATION

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutation analysis in Costello syndrome: functional and structural characterization of theHRASp.Lys117Arg mutation

(2007) Ellen Denayer et al.   HUMAN MUTATION