The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

(2009) Thomas L. Edwards et al.   BIOCHEMICAL JOURNAL

Identification of the SPG15 Gene, Encoding Spastizin, as a Frequent Cause of Complicated Autosomal-Recessive Spastic Paraplegia, Including Kjellin Syndrome

(2008) Sylvain Hanein et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lack of Spartin Protein in Troyer Syndrome

(2008) Joanna C. Bakowska et al.   ARCHIVES OF NEUROLOGY

BMP inhibition enhances axonal growth and functional recovery after spinal cord injury

(2008) Iichiro Matsuura et al.   JOURNAL OF NEUROCHEMISTRY

Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism

(2008) J. Zhao et al.   JOURNAL OF NEUROSCIENCE

Screening of hereditary spastic paraplegia patients for alterations at NIPA1 mutational hotspots

(2008) Christian Beetz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Nervous Wreck Interacts with Thickveins and the Endocytic Machinery to Attenuate Retrograde BMP Signaling during Synaptic Growth

(2008) Kate M. O'Connor-Giles et al.   NEURON

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC