Review
Biochemistry & Molecular Biology
Sander E. Van Der Verren, Giulia Zanetti
Summary: Sar1, a small GTPase protein of the ARF family, plays a role in cargo concentration and membrane deformation by associating with the endoplasmic reticulum membrane and recruiting COPII components. The regulation of Sar1's GTP hydrolysis and its role in coat assembly, as well as the mechanism of Sar1-induced membrane deformation and scission, are still not fully understood, especially in higher organisms with a wider range of secreted cargoes. This review focuses on these aspects and highlights the additional specialization in higher eukaryotes, along with the outstanding questions regarding the orchestration of Sar1 functions.
Review
Pharmacology & Pharmacy
Colin G. Nichols
Summary: Ubiquitously expressed K-ATP channels couple cellular metabolism to electrical activity in multiple tissues through unique assembly as four Kir6 pore-forming subunits and four SUR subunits, leading to a large arsenal of selective channel opener and inhibitor drugs. Gain- or loss-of-function mutations in these channels can result in various pathologies, but therapeutic correction is possible. However, cross-reactivity with other subfamily members may limit the therapeutic usefulness of available drugs, highlighting the need for more specific or effective therapeutic agents.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Woo Sung, Camden M. Driggers, Barmak Mostofian, John D. Russo, Bruce L. Patton, Daniel M. Zuckerman, Show-Ling Shyng
Summary: Regulation of pancreatic KATP channels involves complex interactions between their subunits and ligands. This study investigates the structural changes and ligand interactions associated with channel gating using cryo-EM data. The results show that pharmacological inhibitors and ATP can modulate the channel conformation and affect intra-subunit and inter-subunit interactions.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeong Hun Kim, Han Nim Lee, Xiao Huang, Hyera Jung, Marisa S. Otegui, Faqiang Li, Taijoon Chung
Summary: The plant-specific PI3P-binding protein FYVE2 provides a functional link between the COPII machinery and autophagy by interacting with the small GTPase SAR1 and the PI3P effector ATG18A. FYVE2 regulates autophagosome biogenesis and delivery to vacuoles, working downstream of ATG2. Mutations in FYVE2 or dominant-negative mutant SAR1B proteins result in reduced autophagic flux and organelle accumulation.
Editorial Material
Endocrinology & Metabolism
Colin G. Nichols, Nathaniel W. York, Maria S. Remedi
Summary: Secretion of insulin from pancreatic beta-cells is mainly controlled by ATP-sensitive potassium (K-ATP) channel activity. Genetic mutations that affect K-ATP channel activity can lead to hyperinsulinism or diabetes. Drugs that target K-ATP channels have shown therapeutic effects in related diseases. However, the role of K-ATP channel activity in the development of type 2 diabetes is still not well understood.
Article
Endocrinology & Metabolism
Kelly Velasco, Johanna L. St-Louis, Henrikke N. Hovland, Nels Thompson, Asta Ottesen, Man Hung Choi, Line Pedersen, Pal R. Njolstad, Thomas Arnesen, Karianne Fjeld, Ingvild Aukrust, Line M. Myklebust, Anders Molven
Summary: Functional evaluation of 16 SCHAD missense variants revealed that CHI-associated variants may lead to protein instability or impaired enzymatic activity. Rare variants identified in general populations do not show functional effects on the protein.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Chemistry, Inorganic & Nuclear
Duraisamy Meena, Karuppaiya Vimala, Soundarapandian Kannan
Summary: A nanomaterial drug delivery system was designed for treating colon cancer, with controlled drug release behavior at different pH levels. The combination of DOX and Kaempferol was more efficient in inducing cytotoxic effects compared to each drug alone, with in vivo studies showing significant reduction in tumor volume without severe side effects.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Developmental Biology
L. C. Morley, M. Debant, J. J. Walker, D. J. Beech, N. A. B. Simpson
Summary: The mechanical force of blood flow, known as fluid shear stress (FSS), is crucial for placental development and function. FSS plays a key role in regulating fetoplacental circulatory flow in both normal pregnancy and that affected by fetal growth restriction. Identifying specific mechanical sensors and understanding the mechanisms governing how FSS force is converted into biochemical signals is a rapidly evolving area of research, with potential implications for developing new treatments for FGR.
Article
Environmental Sciences
Murugan Rajadurai, Natchimuthu Karmegam, Soundarapandian Kannan, Ananthanarayanan Yuvaraj, Ramasundaram Thangaraj
Summary: The study demonstrated that the earthworm species Drawida modesta and Lampito mauritii effectively removed polycyclic aromatic hydrocarbons (PAHs) and total petroleum hydrocarbons (TPHs) from oil-contaminated soil. Seed germination assay results showed a significant increase in germination percentage and index in earthworm inoculated treatments.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Psychiatry
Ditte Hulgaard, Charlotte Ulrikka Rask, Henriette Boye, Pia Veldt Larsen, Henrik Thybo Christesen, Marianne Skovsager Andersen, Tina Kold Jensen, Niels Bilenberg
Summary: The study found that during the COVID-19 pandemic, 7-9-year-old children experienced health anxiety symptoms, which were associated with the children's internalizing symptoms at age 5 and the health anxiety symptoms of parents, but not with family exposure to COVID-19 infection.
NORDIC JOURNAL OF PSYCHIATRY
(2022)
Article
Materials Science, Biomaterials
Chandrababu Rejeeth, Alok Sharma, Soundarapandian Kannan, Raju Suresh Kumar, Abdulrahman Almansour, Natarajan Arumugam, Samson Afewerki
Summary: A cost-effective novel biosensor was developed to detect PDGFR associated with cancer progression, achieving a dynamic range of 1-10,000 ng/mL and a detection limit of 1.5 pg/mL using multiwall carbon nanotubes and electrochemical PDGFR conversion sensing. The biosensor displayed good selectivity, repeatability, and stability, providing a pathway for diagnostic interface design and potential new sensor types based on ligand-receptor interactions.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nutrition & Dietetics
Josefine N. Pedersen, Christine Dalgard, Soren Moller, Louise B. Andersen, Anna Birukov, Marianne Skovsager Andersen, Henrik T. Christesen
Summary: Vitamin D status in early pregnancy is inversely associated with blood pressure in children at 5 years old.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Malene Dybdahl, Christine Dalgard, Dorte Glintborg, Marianne Skovsager Andersen, Henrik Thybo Christesen
Summary: This study aimed to investigate the association between maternal testosterone concentrations in the third trimester and offspring handgrip strength (HGS) at the age of 5. The results showed that higher concentrations of free testosterone in the third trimester were associated with lower HGS in 5-year-old children, suggesting a negative effect of maternal testosterone on offspring muscle strength.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Fiona Bartoli, Elizabeth L. Evans, Nicola M. Blythe, Leander Stewart, Eulashini Chuntharpursat-Bon, Marjolaine Debant, Katie E. Musialowski, Laeticia Lichtenstein, Gregory Parsonage, T. Simon Futers, Neil A. Turner, David J. Beech
Summary: Excess activity of PIEZO1 has detrimental effects on the heart, leading to cardiac hypertrophy and fibrosis, partly attributed to amplified PIEZO1 function in cardiac fibroblasts.
Article
Psychiatry
Emily Cantio, Niels Bilenberg, Signe Monrad Norgaard, Iben Have Beck, Soren Moller, Cathriona Cantio, Tina Kold Jensen, Nicoline Bebe Mortensen, Asta Rasmussen, Henrik Boye Thybo Christesen
Summary: This study investigates the association between blood concentrations of serum 25-hydroxyvitamin D at different time points and intelligence quotient score at the age of 7, and explores potential differences in the association based on child sex.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Manickam Rajkumar, Karuppaiya Vimala, Darwin Dasan Tamiliniyan, Ramasundaram Thangaraj, Ramakrishnan Jaganathan, Poomani Kumaradhas, Soundarapandian Kannan
Summary: This study successfully synthesized Ge/PVA/Mg(OH)(2) nanocomposites and demonstrated their good biocompatibility, ability to inhibit Aβ protein expression, and protect neuronal cells from damage. Animal experiments also showed that this nanocomposite has a protective effect on cognitive and synaptic impairments in an AD model. Therefore, Ge/PVA/Mg(OH)(2) nanocomposite may be a potential candidate for treating AD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Chinnaraj Santhosh, Balamuralikrishnan Balasubramanian, Palani Vino, Maluventhen Viji, Chandrababu Rejeeth, Soundarapandian Kannan, Hammad Ullah, Kannan R. R. Rengasamy, Maria Daglia, Arumugam Maruthupandian
Summary: This study successfully biosynthesized selenium nanoparticles (Gw-SeNPs) from Goniothalamus wightii and characterized their properties. The Gw-SeNPs exhibited a polygonal shape and highly crystalline structure. They showed good antibacterial potential against both gram-positive and gram-negative pathogens, as well as demonstrated antioxidant, cytotoxic, and dye degradation abilities.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Louise Kjersgaard Jakobsen, Rikke Beck Jensen, Niels Holtum Birkebaek, Dorte Hansen, Ann-Margrethe Ronholt Christensen, Maja Carsting Bjerrum, Henrik Thybo Christesen
Summary: This study aimed to estimate the national incidence of congenital combined pituitary hormone deficiency (cCPHD) diagnosed before the age of 18, and in subgroups. Data from Danish registries revealed an estimated national incidence of cCPHD of 10.34 per 100,000 births, with an annual incidence rate of 5.74 per million. The incidence was highest in the 1-17 years age group, highlighting the importance of investigating multiple pituitary hormones throughout childhood and adolescence in children with only one hormone deficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Samantha Hover, Frank W. Charlton, Jan Hellert, Jessica J. Swanson, Jamel Mankouri, John N. Barr, Juan Fontana
Summary: By studying the entry process of Bunyamwera virus, we have revealed the promoting effects of high [K+] and low pH. Using sub-tomogram averaging and AlphaFold, we have generated a pseudo-atomic model of the BUNV glycoprotein and located the fusion domain and its chaperone protein. Moreover, we have found that the BUNV envelope undergoes a dramatic rearrangement under specific conditions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sreevani Vellingiri, Chandrababu Rejeeth, Nipun Babu Varukattu, Alok Sharma, Raju Suresh Kumar, Abdulrahman Almansour, Natarajan Arumugam, Samson Afewerki, Soundarapandian Kannan
Summary: In this study, iron nanoparticles were synthesized from goat blood and used as nanocarriers for drug delivery. The results showed that the nanoparticles had good drug release effects in lung cancer cells and could be used for anticancer treatment. Future research will focus on developing targeted nuclear treatment for cancer and other related diseases using different drug carrier systems.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Guillermo Baena, Lingfeng Xia, Sakharam Waghmare, Rucha Anil Karnik
Summary: During pathogenesis, the vesicle trafficking protein SYP132 coordinates with plasma membrane H+-ATPase AHA1 to modulate the trafficking of AHA1 and antimicrobial pathogenesis-related protein 1.