Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Brunty, Kristeena Ray Wright, Brenda Mitchell, Nalini Santanam
Summary: Activation of trimethylation of histone 3 lysine 27 (H3K27me3) by EZH2 plays a role in endometriosis, with higher expression of PRC2 complex components like JARID2, miR-155, and FOXP3 noted in patient tissues. MiR-155 affects the PRC2 complex but has minimal impact on JARID2 expression, suggesting alternative pathways may be involved. A novel crosstalk between miR-155, the PRC2 complex, JARID2, and PHF19 has been identified, providing potential epigenetic targets for further study in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Shashi Bala, Yuan Zhuang, Prashanth Thevkar Nagesh, Donna Catalano, Adam Zivny, Yanbo Wang, Jun Xie, Guangping Gao, Gyongyi Szabo
Summary: This study investigated the therapeutic effect of miR-155 inhibition in liver fibrosis and found that miR-155 deficiency can significantly reduce liver fibrosis. The study also revealed that miR-155 regulates activation of hepatic stellate cells partly via STAT3 signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Yi-Yung Hung, Chen-Kai Chou, Yi-Chien Yang, Hung-Chun Fu, El-Wui Loh, Hong-Yo Kang
Summary: This study found that in patients with major depressive disorder, the expression levels of miR-146a in exosomes were higher, and patients who achieved remission showed lower levels of various microRNAs before treatment and increased levels after treatment. Let-7e, miR-145, and miR-146a showed acceptable discrimination between the remission and non-remission groups.
Review
Oncology
Katerina Kalkusova, Pavla Taborska, Dmitry Stakheev, Daniel Smrz
Summary: MiR-155 is a significant regulator of immune responses against tumors, particularly in different immune cell populations, and it can impact the process of cancer immunoediting. Its role in cellular communication is also important. MiR-155 targeting is increasingly used in cancer immunotherapy.
Article
Immunology
Seungwha Paik, Kyeong Tae Kim, In Soo Kim, Young Jae Kim, Hyeon Ji Kim, Seunga Choi, Hwa-Jung Kim, Eun-Kyeong Jo
Summary: In this study, researchers found that mycobacterial acyl carrier protein (AcpM) can suppress host cell death and promote bacterial growth by upregulating miRNA-155-5p expression. AcpM inhibits certain signaling pathways and fusion processes, interfering with host autophagy and lysosomal function, thus weakening the host's ability to eliminate Mycobacterium tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Hui Yu, Lei Qin, Yunzhi Peng, Wenhui Bai, Zhanli Wang
Summary: The study revealed that exosomes released from hypertrophic cardiomyocytes induced inflammatory responses in macrophages through miR-155, activating various signaling pathways, which may play a crucial role in the development of cardiac hypertrophy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beibei Fu, Xiaoyuan Lin, Shun Tan, Rui Zhang, Weiwei Xue, Haiwei Zhang, Shanfu Zhang, Qingting Zhao, Yu Wang, Kelly Feldman, Lei Shi, Shaolin Zhang, Weiqi Nian, Krishna Chaitanya Pavani, Zhifeng Li, Xingsheng Wang, Haibo Wu
Summary: The research reveals that the miR-342-3p/SOCS6 axis plays a crucial role in regulating anti-Mtb immunity and the balance between cell apoptosis and necrosis during Mtb infection, providing new insights for developing host-directed therapies targeting these pathways.
Article
Multidisciplinary Sciences
Zahra Saadatian, Yaser Mansoori, Lida Nariman-Saleh-Fam, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Ziba Nariman-Saleh-Fam
Summary: This study evaluated the alteration of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with coronary artery stenosis and insignificant coronary artery stenosis compared to healthy individuals. The results showed that three of these miRNAs have the potential to differentiate between coronary artery stenosis patients and healthy individuals, suggesting they could be novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Karina Maciak, Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak
Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Yung-Che Chen, Chang -Chun Hsiao, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu -Ping Chang, Chia-Cheng Tseng, Chiu-Ping Lee, Po-Yuan Hsu, Ting-Ya Wang, Po-Wen Wang, Ting-Wen Chen, Meng-Chih Lin
Summary: This study explores a new approach for treating active tuberculosis (TB) by screening and validating microRNAs with immune-regulatory functions. The research identified differentially expressed microRNAs associated with TB and revealed their roles in regulating autophagy, apoptosis, and macrophage phagocytosis. The findings provide evidence for microRNA-based host-directed immunotherapy and offer new therapeutic targets for treatment-refractory TB.
JOURNAL OF INFECTION
(2022)
Article
Immunology
Mahmoud Mahami-Oskouei, Behrooz Norouzi, Ehsan Ahmadpour, Tohid Kazemi, Adel Spotin, Zahra Alizadeh, Roghayeh Ghorbani Sani, Milad Asadi
Summary: The study compared the expression levels of miR-146a and miR-155 in the plasma of patients with hydatidosis and healthy individuals. The results indicated an increased level of both miR-146a and miR-155 in all hydatidosis patients compared to the control group, with no correlation observed in the level of miR-155 between the two groups. Upregulation of miR-146a and miR-155 in plasma may lead to the development of novel biomarkers for echinococcosis, potentially serving as important biomarkers for determining the severity of hydatidosis.
MICROBIAL PATHOGENESIS
(2021)
Article
Medicine, Research & Experimental
Jose L. Sanchez-Gloria, Roxana Carbo, Mabel Buelna-Chontal, Horacio Osorio-Alonso, Adrian Henandez-Diazcouder, Rosa Luz de la Fuente-leon, Julio Sandoval, Fausto Sanchez, I. Rubio-Gayosso, Fausto Sanchez-Munoz
Summary: Chronic cold exposure exacerbates MCT-induced pulmonary arterial hypertension in rats, resulting in increased levels of inflammatory markers and miRNAs in plasma EVs and lungs.
Article
Microbiology
Min Xiao, Song Yang, An Zhou, Tongxin Li, Jingjing Liu, Yang Chen, Ya Luo, Chunfang Qian, Fuping Yang, Bo Tang, Chunhua Li, Na Su, Jing Li, Mingying Jiang, Shiming Yang, Hui Lin
Summary: This study found that miR-27a-3p and miR-30b-5p affect the progression of TB by targeting VDR, and regulate the secretion of proinflammatory cytokines and macrophage differentiation through the NF-kB inflammatory cytokine signaling pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Qianqian Liu, Yan Gao, Bingyan Zhang, Feng Sun, Qingluan Yang, Yuanyuan Liu, Jing Wu, Kun Chen, Xinhua Weng, Wenhong Zhang, Ruofan Huang, Lingyun Shao
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Letter
Rheumatology
Tao Li, Jing Wu, Qiaoling Ruan, Wenhong Zhang, Wenhong Zhang, Ping Liu, Ning Pei, Xiuhong Xi, Shuihua Lu, Ning Jiang
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Chen Chen, Yi Zhang, Sheng-Lei Yu, Yang Zhou, Si-Yu Yang, Jia-Lin Jin, Shu Chen, Peng Cui, Jing Wu, Ning Jiang, Wen-Hong Zhang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Infectious Diseases
Qingluan Yang, Qiaoling Ruan, Xuefeng Liu, Yaojie Shen, Tian Jiang, Jing Wu, Limin Cai, Kechuan Pan, Miaoyao Lin, Xitian Huang, Lingyun Shao, Wenhong Zhang
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Yiyi Qian, Jingwen Ai, Jing Wu, Shenglei Yu, Peng Cui, Yan Gao, Jialin Jin, Xinhua Weng, Wenhong Zhang
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2020)
Article
Medicine, General & Internal
Bing-Yan Zhang, Zhi-Min Yu, Qing-Luan Yang, Qian-Qian Liu, Hua-Xin Chen, Jing Wu, Sen Wang, Ling-Yun Shao, Xin-Hua Weng, Qin-Fang Ou, Yan Gao, Wen-Hong Zhang
Editorial Material
Environmental Sciences
Jing Wu, Michelle Gamber, Wenjie Sun
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Immunology
Sen Wang, Lei He, Jing Wu, Zumo Zhou, Yan Gao, Jiazhen Chen, Lingyun Shao, Ying Zhang, Wenhong Zhang
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Microbiology
Tao Xu, Xuyang Wang, Lu Meng, Mengqi Zhu, Jing Wu, Yuanyuan Xu, Ying Zhang, Wenhong Zhang
Letter
Virology
Guiqing He, Wenjie Sun, Peipei Fang, Jianping Huang, Michelle Gamber, Jing Cai, Jing Wu
JOURNAL OF MEDICAL VIROLOGY
(2020)
Letter
Virology
Guiqing He, Jing Wu, Jichan Shi, Jianyi Dai, Michelle Gamber, Xiangao Jiang, Wenjie Sun, Jing Cai
JOURNAL OF MEDICAL VIROLOGY
(2020)
Letter
Virology
Jing Cai, Wenjie Sun, Jianping Huang, Michelle Gamber, Jing Wu, Guiqing He
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Immunology
Xuyang Wang, Liqiu Jia, Yang Liu, Jing Wang, Chao Qiu, Tao Li, Wenhong Zhang, Zhaoqin Zhu, Jing Wu, Yanmin Wan
Summary: Individuals with IL12RB1 deficiency are more susceptible to BCG and environmental mycobacteria infections. This study using a mouse model reveals that IL12RB1-deficient mice have impaired tuberculosis suppression, with decreased innate immune responses and increased IL-17 responses. It suggests that IFN-gamma responses alone may not be sufficient to contain BCG infection in the setting of IL12RB1 deficiency.
Article
Virology
Xuyang Wang, Yumeng Zhang, Yinyin Ben, Chao Qiu, Jing Wu, Wenhong Zhang, Yanmin Wan
Summary: This study reveals a negative correlation between anti-HBc IgG responses in early HBV infection and virus replication, and demonstrates the inhibitory effect of anti-HBc antibodies on virus replication. This finding has significant implications for immunotherapy against hepatitis B.
Article
Immunology
Tao Li, Xian Zhou, Yun Ling, Ning Jiang, Jingwen Ai, Jing Wu, Jiazhen Chen, Li Chen, Xiaowen Qian, Xuhui Liu, Xiuhong Xi, Lu Xia, Xiaoyong Fan, Shuihua Lu, Wen-Hong Zhang
FRONTIERS IN IMMUNOLOGY
(2019)