Article
Biotechnology & Applied Microbiology
Jian Xiao, Chuming Zhu, Peidong Ni, Wangwang Chen, Zengliang Li, Hao Fan, Xiang Ma, Zekuan Xu, Li Yang
Summary: The study found that the polymorphism rs61396151 in the SNHG5 gene is associated with a decreased risk of gastric cancer, but not with clinicopathological features. However, it was associated with overall survival rate, which was reversed after adjustments.
Article
Medicine, Research & Experimental
Luying Qiu, Yuye Wang, Fang Liu, Shumin Deng, Zhiyi He, Wenxu Zheng, Yanzhe Wang
Summary: This study investigated the association between pri-let-7f gene polymorphisms and ischemic stroke (IS). The results showed a significant increase in the risk of IS associated with the A alleles and AA genotypes of both loci. Variant genotypes of rs17276588 may also increase the risk of IS in females with alcohol intake. Gene-gene interaction analysis revealed combined effects of mutations in these SNPs. These findings suggest pri-let-7f SNPs as potential latent biomarkers for the risk of IS, but further studies are needed for clarification.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Immunology
Christian Vaquero-Yuste, Ignacio Juarez, Marta Molina-Alejandre, Elisa Maria Molanes-Lopez, Adrian Lopez-Nares, Fabio Suarez-Trujillo, Alberto Gutierrez-Calvo, Adela Lopez-Garcia, Inmaculada Lasa, Remedios Gomez, Eduardo Fernandez-Cruz, Carmen Rodrigez-Sainz, Antonio Arnaiz-Villena, Jose Manuel Martin-Villa
Summary: A study on 107 Spanish patients with gastric adenocarcinoma and 58 healthy controls revealed that the frequency of the 14bp DEL allele in the HLA-G gene was significantly increased in patients, as well as the haplotype formed by the combination of 14bp DEL/+3142 C variants. Patients with the 14bp DEL/DEL genotype showed a lower 5-year life expectancy compared to other genotypes. The findings suggest a potential association between HLA-G gene polymorphisms and gastric adenocarcinoma susceptibility, disease progression, and survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Review
Biochemistry & Molecular Biology
Wenwen Wei, Xin Wang, Yuanzhong Zhou, Xuejun Shang, Hongsong Yu
Summary: Pregnancy-induced hypertension (PIH) is a severe pregnancy complication that can lead to maternal mortality. Various genetic factors have been shown to play an important role in the occurrence and development of PIH. This review summarizes the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks that may contribute to the pathogenesis of PIH.
Article
Oncology
Yihan Cui, Wenjin Wang, Peipei Luo, Yun Feng, Chen Mi, Ai Jia
Summary: This study found that SP4 gene polymorphisms are associated with gastric cancer risk, and specific genotypes may reduce the risk of gastric cancer.
Article
Oncology
Giulia Peduzzi, Manuel Gentiluomo, Francesca Tavano, Paolo Giorgio Arcidiacono, Stefano Ermini, Pavel Vodicka, Ugo Boggi, Giulia Martina Cavestro, Gabriele Capurso, Luca Morelli, Anna Caterina Milanetto, Raffaele Pezzilli, Rita T. Lawlor, Silvia Carrara, Martin Lovecek, Pavel Souc, Feng Guo, Thilo Hackert, Faik G. Uzunoglu, Maria Gazouli, Andrea Parniczky, Juozas Kupcinskas, Maarten F. Bijlsma, Bas Bueno-de-Mesquita, Roel Vermeulen, Casper H. J. van Eijck, Krzysztof Jamroziak, Renata Talar-Wojnarowska, William Greenhalf, Domenica Gioffreda, Maria C. Petrone, Stefano Landi, Livia Archibugi, Marta Puzzono, Niccola Funel, Cosimo Sperti, Maria L. Piredda, Beatrice Mohelnikova-Duchonova, Ye Lu, Viktor Hlavac, Xin Gao, Martin Schneider, Jakob R. Izbicki, George Theodoropoulos, Stefania Bunduc, Edita Kreivenaite, Olivier R. Busch, Ewa Malecka-Panas, Eithne Costello, Francesco Perri, Sabrina Gloria Giulia Testoni, Giuseppe Vanella, Claudio Pasquali, Martin Oliverius, Hermann Brenner, Martin Loos, Mara Gotz, Konstantinos Georgiou, Alint Eross, Evaristo Maiello, Andrea Szentesi, Francesca Bazzocchi, Daniela Basso, John P. Neoptolemos, P. Eter Hegyi, Vytautas Kiudelis, Federico Canzian, Daniele Campa
Summary: Mitochondrial metabolism has been linked to PDAC risk, with genetic variability potentially playing a role. However, this study did not find significant associations between mtSNPs or n-mtSNPs and PDAC risk. Gene-level analysis highlighted three genes (TERT, SUGCT, and SURF1) that showed some association with PDAC, but not at a statistically significant level.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Xiang Ma, Younan Wang, Hao Fan, Chuming Zhu, Wangwang Chen, Zengliang Li, Jian Xiao, Peidong Ni, Zekuan Xu, Li Yang
Summary: This study investigated the correlation of CTSB-related polymorphisms with gastric cancer (GC) risk and prognosis, finding that certain variants were associated with decreased risks of GC, earlier T stage, and better overall prognosis. The results suggest the importance of CTSB-related polymorphisms in predicting GC risk and prognosis.
Article
Immunology
Xuanyan Cai, Huiyan Zha, Zhaoxu Yang, Yiwen Du, Xiaoyang Dai, Bo Yang, Jiajia Wang, Qiaojun He, Qinjie Weng
Summary: In this study, the relationship between TGF-beta 1 polymorphisms and susceptibility to chronic liver disease (CLD) was systematically analyzed using 35 eligible studies. The findings indicate that certain TGF-beta 1 gene variations are associated with an increased risk of CLD. Additionally, TGF-beta 1 gene expression is significantly elevated in CLD patients, and a TGF-beta 1 codon 263 variant may affect the secretion of TGF-beta 1 by altering its dimerization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiyon Yu, Yoon Jeong Choi, Sung-Hwan Choi, Han-Sung Jung, Ji Hyun Lee, Jung-Yul Cha
Summary: By conducting targeted next-generation sequencing on orthodontic patients, genetic factors affecting treatment duration were elucidated. Specific genetic polymorphisms were identified and found to be associated with the length of orthodontic treatment, providing important insights for predicting treatment duration and aiding both patients and orthodontists.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Yingjun Zhang, Weijian Lin, Weiping Jiang, Zhenfa Wang
Summary: The recurrence and metastasis of gastric cancer are related to the stemness of gastric cancer cells. Research has shown a negative correlation between miR-18 level and the occurrence and development of certain cancer types. This study investigates the effects of miR-18 on the stemness of gastric cancer cells through the construction of gastric cancer cell lines with stable overexpression of miR-18. The study finds that miR-18 targets Meis2 and involves the low-expressed oncogene HMGB3 in promoting the stemness of gastric cancer cells. These findings suggest that the miR-18/Meis2/HMGB3 axis may serve as a potential prognostic indicator for patients with gastric cancer.
Review
Oncology
Qimeng Zhang, Xueying Xu, Mingcheng Wu, Tiantian Qin, Shaoning Wu, Hongbo Liu
Summary: The study conducted a network meta-analysis on four single nucleotide polymorphisms in miRNAs and found that miR-196a2 rs11614913 was significantly associated with the susceptibility of HCC, especially in HBV-related cases, while the other three miRNA genes did not show significant associations. MiR-196a2 could serve as the best predictor of susceptibility in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Qi Liu, Danyan Li, Yunkai Dai, Yunzhan Zhang, Shaoyang Lan, Qi Luo, Jintong Ye, Xu Chen, Peiwu Li, Weijing Chen, Ruliu Li, Ling Hu
Summary: This study aimed to investigate the relationship between miR-146a, miR-196a2, miR-149, miR-499, and miR-27a gene single nucleotide polymorphisms (SNPs) and their expressions with pathological changes in gastric mucosa, and to further analyze the interactions between SNPs and Hp. The results showed that miR-196a2 rs11614913 and miR-27a rs895819 may affect the genetic susceptibility to gastric precancerous lesions (GPL) or gastric cancer (GC). The up-regulation of miR-499, miR-196a2, and miR-27a expression caused by Hp infection may be an important mechanism of gastric carcinogenesis.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Piao Jiang, Bin Liang, Zhen Zhang, Bing Fan, Lin Zeng, Zhiyong Zhou, Zhifang Mao, Qing Lin, Weirong Yao, Qinglin Shen
Summary: The aim of this study was to investigate the expression of miRNA-146a-5p in gastric cancer tissues and its effects on the behavior of MKN-28 cells. It also aimed to identify the function of its target gene CDC14A in gastric cancer. The results showed that miRNA-146a-5p levels were significantly decreased in gastric cancer tissues and cells, and it directly targeted CDC14A.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Toxicology
Xiaowei Wang, Dan Guan, Dafei Wang, Hanting Liu, Yanling Wu, Weida Gong, Mulong Du, Haiyan Chu, Jing Qian, Zhengdong Zhang
Summary: The study revealed the crucial regulatory role of m(6)A modification genes in gastric cancer (GC) development, with the SNP rs9906944 C > T in IGF2BP1 significantly associated with a decreased risk of GC. Higher expression of IGF2BP1 was linked to poorer overall survival in GC patients.
ARCHIVES OF TOXICOLOGY
(2021)