Article
Rheumatology
Yu Fu, Qing Lin, Zhi-rong Zhang
Summary: Our meta-analysis demonstrated that the TNFSF4 rs2205960, rs1234315, and rs844840 SNPs were significantly associated with an increased risk of SLE. In contrast, rs844644 polymorphism showed no significant association, and neither did rs844648 nor rs10489265 polymorphisms with SLE susceptibility.
ADVANCES IN RHEUMATOLOGY
(2021)
Article
Immunology
Lu-Yao Yue, Yuan Xu, Bei Tao, Chen-Song He
Summary: The present study found that plasma levels of TNFSF4 were significantly elevated in SLE patients of Southern Chinese Han origin. These elevated levels were positively associated with SLE disease activity score, optic nerve injury, leukopenia, and hypocompleminemia. Additionally, multiple polymorphisms in the TNFSF4 gene were significantly related to SLE susceptibility.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Review
Medicine, Research & Experimental
Hamidreza Ebrahimiyan, Shayan Mostafaei, Saeed Aslani, Seyedeh Tahereh Faezi, Elham Farhadi, Ahmadreza Jamshidi, Mahdi Mahmoudi
Summary: In this study, a meta-analysis was performed to investigate the association between ITGAM gene rs1143679 SNP and MBL gene rs1800451 SNP with SLE risk. The results showed a significant positive association between rs1143679 and SLE risk, while rs1800451 was significantly associated with decreased susceptibility to SLE.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study found that circulating IL-33 levels were significantly higher in patients with SLE, suggesting a relationship between IL-33 and SLE. Additionally, the research identified an association between the IL-33 rs1891385 polymorphism and SLE susceptibility.
Article
Allergy
Zongqing Liu, Tong Sun, Linjian Song, Xiaoxing Xue, Shuang Liu, Huihui Kuang, Liyuan Tian, Zheng Xiao
Summary: This meta-analysis found that interleukin polymorphisms, particularly IL-1, IL-4, IL-6, and IL-10, may impact the predisposition of SLE. The results varied among different ethnicities, with positive findings observed in Asians for certain polymorphisms and in Caucasians for others.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Lin Zhu, Peng Chen, Xuanjing Sun, Shuo Zhang
Summary: This meta-analysis suggests that IL-1A +4845G/T and IL-1B +3954C/T polymorphisms may influence the risk of RA, whereas IL-1A -889C/T, IL-1B -31T/C, and IL-1B -511C/T polymorphisms may influence the risk of SLE.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Ning Chen, Yijun Dai, Juanjuan He, Meng Zhou, Hong Sun, Ling Lin, Fei Gao, He Lin, Qing Yan
Summary: This meta-analysis investigated the relationship between TGF-beta 1 gene polymorphisms and systemic lupus erythematosus (SLE), and found that TGF-beta 1 C509T, G915C, and T869C polymorphisms were not associated with SLE risk.
Review
Medicine, General & Internal
Napoleon Bellua Sam, Shi-Yang Guan, Peng Wang, Xiao-Mei Li, De-Guang Wang, Hai-Feng Pan, Dong-Qing Ye
Summary: This study revealed significantly higher MIF levels in SLE patients compared to healthy controls, with Asians and younger patients showing even higher MIF levels. The association between SLE and MIF-173 C/G was supported, while no significant relationship was found between MIF-794 CATT and SLE.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Rheumatology
Mario Adan Moreno-Eutimio, Carmen Estefania Martinez-Aleman, Ivan Sammir Aranda-Uribe, Guillermo Aquino-Jarquin, Carlos Cabello-Gutierrez, Jose Manuel Fragoso, Rosa Elda Barbosa-Cobos, Miguel A. Saavedra, Julian Ramirez-Bello
Summary: This study investigates the association of three TNFSF4 single nucleotide variants with SLE susceptibility in Mexican patients. The results indicate that TNFSF4 rs1234315T/C, rs2205960G/T, and rs704840T/G are risk factors for SLE in Mexicans. Additionally, meta-analysis suggests that TNFSF4 rs2205960G/T is a risk factor for SLE in Latin Americans and Asians.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Melissa Northcott, Linden J. Gearing, Julie Bonin, Rachel Koelmeyer, Alberta Hoi, Paul J. Hertzog, Eric F. Morand
Summary: The effects of medication on gene module expression in SLE patients are significant, emphasizing the need to control for medication exposure in studies of gene expression in SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Fengping Liu, Tianli Ren, Xiaodi Li, Qixiao Zhai, Xifeng Xu, Nan Zhang, Peng Jiang, Yaofang Niu, Longxian Lv, GuoXun Shi, Ninghan Feng
Summary: The microbiome alterations in the gut and oral cavity are associated with the development of systemic lupus erythematosus (SLE). Research on 35 SLE patients revealed reduced bacterial richness and diversity in feces, and increased bacterial diversity in saliva. These findings suggest that different body niches in SLE patients have distinct bacterial profiles that may play a role in the disease development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Sudha Raghunath, Yifat Glikmann-Johnston, Vera Golder, Rangi Kandane-Rathnayake, Eric F. Morand, Julie C. Stout, Alberta Hoi
Summary: Cognitive dysfunction in SLE is associated with organ damage, but not disease activity, and is negatively associated with serological activity and high IFN signature. Clinicians often fail to recognize cognitive dysfunction in SLE patients.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Zhi-Chao Yuan, Wang-Dong Xu, You-Yu Lan, Jia-Min Wang, Qian Wu, Jie Zhou, An-Fang Huang
Summary: This study suggests that the A\B and A\O polymorphisms of the MBL2 gene are associated with SLE susceptibility, and the allele H may act as a protective factor for SLE.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Multidisciplinary Sciences
Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This meta-analysis revealed that the circulating level of interleukin-18 is significantly higher in systemic lupus erythematosus (SLE) patients compared to healthy controls. Patients with higher SLEDAI scores, Asian, White, Arab, or mixed ethnicity tend to have elevated levels of IL-18, indicating the potential role of IL-18 in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study compared the effectiveness and safety of voclosporin + MMF, tacrolimus + MMF, and monotherapy for induction treatment in lupus nephritis patients. The results showed that tacrolimus + MMF and voclosporin + MMF were more effective than monotherapy, with tacrolimus + MMF being the most effective. However, tacrolimus + MMF had a higher risk of serious adverse events compared to monotherapy.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study evaluated the effectiveness and safety of Janus kinase (JAK) inhibitors in patients with active psoriatic arthritis (PsA). The results showed that Filgotinib 200 mg and Upadacitinib 30 mg were the most effective in terms of ACR response rates, while Tofacitinib 10 mg was the most effective treatment based on PASI75. However, there were no significant differences in adverse events (AEs) and serious adverse events (SAEs) among the treatment options.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Review
Pharmacology & Pharmacy
Young Ho Lee, Gwan Gyu Song
Summary: This study assessed the relative efficacy and safety of various biological agents used in induction therapy for lupus nephritis. The results showed that low-dose IL-2, obinutuzumab, rituximab, and belimumab had higher complete remission rates and lower risk of serious adverse events compared to the control, indicating their superiority as treatments for lupus nephritis.
Article
Dermatology
Young Ho Lee, Gwan Gyu Song
Summary: This study found a correlation between VDR ApaI and BsmI polymorphisms and vitiligo susceptibility in the Asian population, while no association was observed for TaqI and FokI polymorphisms in European, Asian, Arab, and Latin American populations.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study compared the efficacy and tolerability of IL-6 and JAK inhibitor therapies with adalimumab in patients with RA and inadequate responses to MTX. The results showed that IL-6 and JAK inhibitors were more effective in achieving ACR20 response rate compared to adalimumab. However, adalimumab was associated with lower risk of serious adverse events.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study aimed to evaluate the effectiveness of initiating urate-lowering therapy (ULT) during acute gout episodes. The findings suggest that initiating ULT therapy during a gout attack does not increase the duration of the flare or aggravate pain.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study investigated the association between leptin levels in the blood of individuals with rheumatoid arthritis (RA) and the severity of the disease. The results showed that RA patients had elevated leptin levels, which were correlated with the activity of RA. These findings suggest that leptin plays a significant role in the pathophysiology of RA.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ahreum Kim, Sung Jae Choi, Gwan Gyu Song, Joo-Hang Kim, Jae Hyun Jung
Summary: This study aimed to identify differentially expressed genes (DEGs) of systemic lupus erythematosus (SLE) using gene expression-based computational methodologies. A total of 39 upregulated genes and 57 downregulated genes were identified in SLE patients compared to healthy controls. These DEGs were implicated in immune response pathways and were also associated with various virus infections. Additionally, certain genes were found to be closely associated with the quantities of immune cells.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Young Ho Lee, Gwan Gyu Song
Summary: Through a meta-analysis, we found that the OPN 707 T/C variant is associated with SLE susceptibility in European and Arab populations, the OPN 9250 T/C variant is associated with SLE susceptibility in Asian and Arab populations, and significant associations were also found between the OPN 1239 C/A variant and SLE.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: This study aims to evaluate the standardized mortality ratios (SMRs) in patients with systemic sclerosis (SSc). The overall SMR of SSc patients is higher than that in the general population, and the SMR is significantly increased in both men and women. The mortality rate is also higher in diffuse cutaneous SSc (dcSSc) compared to limited cutaneous SSc (lcSSc).
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Young Ho Lee, Gwan Gyu Song
Summary: According to this meta-analysis, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can be regarded as general markers of inflammation. Behcet's disease (BD) patients have higher NLR and PLR compared to healthy controls.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Review
Public, Environmental & Occupational Health
Young Ho Lee, Gwan Gyu Song
Summary: The meta-analysis demonstrated that Nintedanib is effective for patients with ILD with or without SSc, but it is associated with an increased incidence of adverse events and withdrawals due to adverse events.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2023)
