Journal
HUMAN IMMUNOLOGY
Volume 72, Issue 8, Pages 656-662Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2011.03.027
Keywords
Tuberculosis; Antimicrobial peptides; Diabetes
Categories
Funding
- National Council of Science and Technology in Mexico (CONACYT) [CB-2007-01-82424, FOMIX-Zacatecas- 2008-C01-109189, CONACYT-FOSSIS 2008-87863, CONACYT FS SALUD 2005-02-1444]
Ask authors/readers for more resources
Tuberculosis (TB) is one of the most important infectious diseases, causing 1.8 million deaths annually worldwide. This problem has increased because of the association with human immmunodeficiency virus and diabetes mellitus type 2, mainly in developing countries. In the past few years it has been highlighted the significance of antimicrobial peptides in the immunopathogenesis of TB ex vivo and in experimental models studies. In this study we analyzed the expression of CAMP, DEFA1, DEFB4, and DEFB103A in patients with latent TB and progressive TB with and without comorbidity with diabetes mellitus type 2. Antimicrobial peptide gene expression increased during progressive TB, which could be used as a biomarker for reactivation. By contrast, patients with diabetes mellitus type 2 have lower antimicrobial peptides gene expression, suggesting that the lack of its proper production in these patients contribute to enhance the risk for TB reactivation. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available