Review
Immunology
Simon Jasinski-Bergner, Dominik Schmiedel, Ofer Mandelboim, Barbara Seliger
Summary: This review provides a summary of the expression, regulation, function, and impact of HLA-G in the context of different viral infections, including virus-associated cancers. It emphasizes the potential use of HLA-G as a novel diagnostic and prognostic biomarker for viral infections, as well as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Natalia M. Araujo, Carla Osiowy
Summary: This review reflects on the major milestones in HBV/G research, highlighting its unique features and common pitfalls in detection. The comprehensive analysis of epidemiological data provides insights into the origin and potential re-emergence of this genotype.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulze zur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: Bulevirtide treatment reduces HDV RNA and ALT levels in patients with chronic hepatitis D, with a dose-dependent effect.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulzezur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: In this study, it was found that bulevirtide is effective in inhibiting the entry of hepatitis D virus and reducing the progression of liver disease in patients with chronic hepatitis B. The recommended dosage of bulevirtide is 2 mg or 10 mg per day.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cell Biology
Fanyun Kong, Fulong Zhang, Xiangye Liu, Suping Qin, Xiaoying Yang, Delong Kong, Xiucheng Pan, Hongjuan You, Kuiyang Zheng, Renxian Tang
Summary: Calcium acts as a ubiquitous second messenger in HBV infection, elevating cytosolic Ca2+ levels through different channels and promoting viral replication. Targeting Ca2+ signaling is an effective approach for the treatment of HBV infection.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Virology
Xuelian Deng, Dan Liu, Maelenn Pailine Delcourt, Huihui Gao, Lu Zhou, Daniel Candotti
Summary: Between 2011 and 2021, a total of 869,633 blood donations were collected from prequalified donors in Dalian, China. Only 0.12% of the samples were confirmed to be positive for hepatitis B virus (HBV). Testing for hepatitis delta virus (HDV) antibodies in 2175 donations revealed that only 0.09% of the samples showed weak reactivity, but they were confirmed to be false positives upon repeat testing. Among the confirmed occult HBV infection (OBI) samples, only one non-Chinese donor showed repeated reactivity to HDV antibodies, suggesting that HDV/HBV coinfection does not play a significant role in the genesis of OBI. Overall, the data indicated a very low prevalence of HDV infection among blood donors in Liaoning province, Northeast China.
Article
Genetics & Heredity
Haibing Gao, Xiangmei Wang, Huaxi Ma, Shenglong Lin, Dongqing Zhang, Wenjun Wu, Ziyuan Liao, Mengyun Chen, Qin Li, Minghua Lin, Dongliang Li
Summary: The role of genetic factors in the occurrence and progression of CHB is important. METTL16, an m(6)A regulator involved in mRNA intron splicing, participates in the progression of CHB fibrosis by regulating the m(6)A level and expression of HLA-DPB1.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Guojin Ou, Xiaojuan Liu, Yongmei Jiang
Summary: This meta-analysis reveals that specific HLA-DPB1 alleles are significantly associated with an increased antibody response to the HB vaccine, further elucidating the role of genetic factors in this immune response.
Article
Immunology
Claudia Hawkins, Minhee Kang, Debika Bhattacharya, Gavin Cloherty, Mary Kuhns, Roy Matining, Chloe Thio, Wadzanai Samaneka, Lameck Chinula, Nyirenda Mulinda, Sharlaa Badal-Faesen, Patcharaphan Sugandhavesa, Javier Lama, Simani Gaseitsiwe, Vera Holzmayer, Mark Anderson, Robert Murphy, Marion Peters
Summary: This study aims to identify serum biomarkers that assess the HBV cccDNA reservoir and predict functional cure in HIV/HBV co-infection. The results support the use of TDF-based DUAL-HBV active ART as the initial treatment option for HIV/HBV co-infection and suggest that HBV RNA could be a useful marker for evaluating treatment response in these patients.
Article
Immunology
Jade Pattyn, Greet Hendrickx, Alex Vorsters, Pierre Van Damme
Summary: The coverage of hepatitis B vaccines is increasing, and the effective implementation of vaccination programs has significantly reduced the morbidity and mortality related to hepatitis B.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Isabelle Desombere, Freya Van Houtte, Ali Farhoudi, Lieven Verhoye, Caroline Buysschaert, Yvonne Gijbels, Sibyl Couvent, Wilfried Swinnen, Hans Van Vlierberghe, Andre Elewaut, Andrea Magri, Zania Stamataki, Philip Meuleman, Jane A. McKeating, Geert Leroux-Roels
Summary: Hepatitis C virus can be transmitted by B cells, but B cells from recently infected patients failed to transmit the virus to mice, while all serum samples were infectious. The study also observed an association between circulating antibodies and B cell transmission of HCV.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Gabriela Loredana Popa, Mircea Ioan Popa
Summary: Oxidative stress plays an important role in infections, especially viral liver infections. Excessive reactive oxygen species have harmful effects on cells. Recent research shows the close relationship between oxidative stress and the pathogenesis of chronic hepatitis B, potentially providing new markers for evaluating and monitoring patients.
Review
Biochemistry & Molecular Biology
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara
Summary: Chronic hepatitis B virus (HBV) infection is a major global health problem, and the link between Toll-like receptors (TLRs) and chronic HBV infection is being increasingly recognized. TLR agonists have the potential to enhance the host immune response against HBV infection and improve CHB treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Hao Wang, Fenfang Liao, Junmo Xie, Wenbo Gao, Min Wang, Jieting Huang, Ru Xu, Qiao Liao, Zhengang Shan, Yourong Zheng, Xia Rong, Chengyao Li, Yongshui Fu
Summary: The study revealed that E2G/A/V/D mutations significantly influence the detection of HBsAg, with different underlying mechanisms for OBI caused by E2 mutations in genotype B and genotype C. Additionally, E2G/A mutations may result in a N-terminal truncated S protein, contributing to HBsAg secretion impairment in OBI.
FRONTIERS IN MICROBIOLOGY
(2021)