Article
Multidisciplinary Sciences
Shoeib Moradi, Sanda Stankovic, Geraldine M. O'Connor, Phillip Pymm, Bruce J. MacLachlan, Camilla Faoro, Christelle Retiere, Lucy C. Sullivan, Philippa M. Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn, Andrew G. Brooks, Julian P. Vivian
Summary: KIR2DL2 and KIR2DL3, two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family, regulate NK cell activation by interacting with HLA-C1, but differ in their recognition mechanism and functionality towards HLA-C1 allotypes.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Cell Biology
Xiaofei Ai, Jiying Wang, Yan Zhang, Qinghua Li, Xiaojing Wang
Summary: HLA-DQB1*04:62 differs from HLA-DQB1*04:01:01:01 by a single nucleotide in exon 3 (433A->G, N113D), resulting in a change of amino acid.
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: A single nucleotide substitution in codon 97 of the HLA-B*15:01:01:01 gene results in the emergence of a novel allele, HLA-B*15:35.
Review
Nanoscience & Nanotechnology
Jin Yang, Hongna Liu, Wenjing Pan, Mengru Song, Yutong Lu, Franklin Wang-Ngai Chow, Polly Hang-Mei Leung, Yan Deng, Masahi Hori, Nongyue He, Song Li
Summary: This article discusses the importance of the major histocompatibility complex (MHC) in humans and the rapid and accurate HLA typing technology established for preventing graft-verses-host disease (GVHD) in organ transplantation. The article also summarizes the most widely used sequencing typing platforms and the latest developments in HLA typing kits.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Editorial Material
Cell Biology
Kuo-Liang Yang, Tsung-Chih Chen, Chieh-Lin J. Teng, Py-Yu Lin
Summary: A nucleotide substitution in codon 316 of the HLA-A*24:02:01:01 gene has led to the creation of a novel allele, HLA-A*24:353.
Editorial Material
Cell Biology
Feng Liu, Jianhua Chen
Summary: The only difference between HLA-DQB1*04:74 and HLA-DQB1*04:01:01:01 is a nucleotide substitution at codon 54 in exon 2.
Editorial Material
Cell Biology
Kuo-Liang Yang, Kang-Hsi Wu, Py-Yu Lin
Summary: A nucleotide substitution in codon 268 of HLA-A*11:02:01:01 results in the formation of a novel allele, HLA-A*11:77.
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: A nucleotide substitution in codon 40 of HLA-C*12:02:01 leads to the creation of a novel allele, HLA-C*12:130.
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: Recombination between HLA-B*15:01:01:01 and HLA-B*54:01:01:01, HLAB*55:02:01:01, or HLA-B*59:01:01:01 resulted in the novel allele of HLA-B*15:86.
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: The passage describes a nucleotide substitution at codon 114 of the HLA-B*40:01:01 gene, resulting in a novel allele called HLA-B*40:33.
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: This sentence indicates that HLA-A*11:263 is located on the haplotype HLA-A*11:263-C*03:04:01-B*13:01.
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: A nucleotide substitution at position 594 of the HLA-DRB1*14:54:01:01 gene results in a novel allele, HLA-DRB1*14:227.
Editorial Material
Cell Biology
Maria Zamanakou, Sophia Vatsiou, Savvas Stokidis, Sotirios P. Fortis, Anastasios E. Germenis
Summary: Two novel alleles, HLA-A*02:01:193 and -DQA1*02:17, were identified in Greek individuals using NGS technology.
Article
Biochemical Research Methods
Yue Shen, Jerry M. Parks, Jeremy C. Smith
Summary: The HLA-Clus package provides a clustering method for HLA Class I alleles based on their 3D structural similarity. It can be used in HLA functional studies and disease association studies.
BMC BIOINFORMATICS
(2023)
Editorial Material
Cell Biology
Angeliki Xagorari, Maria Zamanakou, Sofia Vatsiou, Anastasios E. Germenis, Damianos Sotiropoulos
Summary: The new alleles A*02:943 and B*51:104:02 were identified in Greek cord blood units.
Article
Computer Science, Information Systems
Chisato Imai, Rae-Anne Hardie, Guilherme Saffi Franco, Gorkem Sezgin, Kathy Tepper, Adam McLeod, Christopher Pearce, Johanna Westbrook, Andrew Georgiou
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2020)
Article
Medicine, General & Internal
Nasir Wabe, Rae-Anne Hardie, Robert Lindeman, Craig Scowen, Alex Eigenstetter, Andrew Georgiou
Summary: The study found that a significant proportion of patients in Australian hospitals undergo potentially redundant repeat liver function testing, despite guidelines recommending a minimum interval of at least 48 hours. Patients in general wards and ICUs had proportions of at least one PRRT of 52.3% and 83.9%, respectively.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Health Care Sciences & Services
Chisato Imai, Ling Li, Rae-Anne Hardie, Andrew Georgiou
Summary: This study aimed to examine the association between recommended HbA1c testing frequency and patient outcomes. Better adherence to guideline-recommended testing frequency was associated with better glycaemic control and lower risk of chronic kidney disease.
BMJ QUALITY & SAFETY
(2021)
Letter
Medicine, General & Internal
Guilherme S. Franco, Rae-Anne Hardie, Ling Li, Chisato Imai, Gorkem Sezgin, Julie Li, Adam McLeod, Christopher Pearce, Andrew Georgiou
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Article
Health Policy & Services
Andrew Georgiou, Julie Li, Christopher Pearce, Adam McLeod, Nasir Wabe, Rae-Anne Hardie, Guilherme Saffi Franco, Chisato Imai, Gorkem Sezgin, Judith Thomas, Zhaoli Dai, Muhammad Kashif Sheikh, Amanda Proposch, Stephen Weeding, Brendon Wickham, Tony Badrick, Darnel Murgatroyd
Summary: This project aims to examine the feasibility of using near real-time electronic general practice data to promote effective care and best-practice policy. The study will be carried out over 1.5 years using data from over 450 general practices within three Victorian PHNs and supplemented by data from two PHNs in New South Wales. The project will lead to the building of a meaningful near real-time COVID-19 geospatial reporting framework and dashboard for decision-makers to identify and monitor emerging trends and the impact of interventions/policy decisions.
HEALTH RESEARCH POLICY AND SYSTEMS
(2021)
Letter
Medicine, General & Internal
Zhaoli Dai, Gorkem Sezgin, Rae-Anne Hardie, Precious McGuire, Christopher Pearce, Adam McLeod, Andrew Georgiou
Summary: This study analyzed the sociodemographic characteristics of telehealth utilization in Australia during the COVID-19 pandemic from March 2020 to August 2021. The sample included 860 general practice providers and 3,161,868 patients, with a total of 24,527,274 consultations recorded. Telehealth accounted for 37.6% of the consultations, with videoconferencing representing 2.4% and phone consultations representing 35.2%. Regression analyses indicated that older adults, those living in rural communities, and migrants from non-English speaking countries had lower utilization of videoconferencing compared to phone consultations.
INTERNAL MEDICINE JOURNAL
(2023)
Letter
Medicine, General & Internal
Rae-Anne Hardie, Gorkem Sezgin, Lisa G. Pont, Judith Thomas, Mirela Prgomet, Precious McGuire, Christopher Pearce, Andrew Georgiou
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Public, Environmental & Occupational Health
Judith Thomas, Gorkem Sezgin, Precious Mcguire, Rae-Anne Hardie, Guilherme S. Franco, Margaret Williamson, Andrew Georgiou
Summary: This study examined the utilization of telehealth for mental health consultations in Australian general practice during the COVID-19 pandemic. The findings showed widespread use of telehealth, especially video consultations, between 2020 and 2021. Females, Victoria residents, regional/remote areas, and those seeking consultations in 2020 were more likely to use telehealth.
PUBLIC HEALTH RESEARCH & PRACTICE
(2023)
Article
Health Care Sciences & Services
Chisato 'Chrissy' Imai, Ling Li, Rae-Anne Hardie, Christopher Pearce, Andrew Georgiou
Summary: This study investigates factors associated with adherence to guideline-recommended HbA1c testing frequency in patients with type 2 diabetes. The findings suggest that patient age, medication use, practice size, and financial incentives are associated with adherence to 6-monthly testing.
AUSTRALIAN JOURNAL OF PRIMARY HEALTH
(2023)
Article
Health Care Sciences & Services
Judith Thomas, Chisato Imai, Gorkem Sezgin, Rae-Anne Hardie, Stephen Weeding, Christopher Pearce, Adam McLeod, Precious McGuire, Shirmilla Datta, Julie Li, Nasir Wabe, Guilherme S. Franco, Zhaoli Dai, Gihan de Mel, Emma Gault, Muhammad Kashif Sheikh, Andrew Georgiou
Summary: The COVID-19 pandemic and response measures have directly affected Australian primary care services. A research project was conducted to understand the impact on general practice activity, involving collaboration between researchers, general practitioners, data custodians, and primary health networks. The project utilized action research cycles, engaged governance, and produced relevant knowledge outcomes.
AUSTRALIAN JOURNAL OF PRIMARY HEALTH
(2023)
Article
Primary Health Care
Chisato Imai, Judith Thomas, Rae- Anne Hardie, Christopher Pearce, Tony Badrick, Andrew Georgiou
Summary: This study analyzed the utilization of telehealth by T2DM patients in Australia and compared the differences between telehealth and face-to-face consultations. The results showed that telehealth was widely used and was equally effective as face-to-face consultations in diabetes monitoring.
Article
Medicine, General & Internal
Rae-Anne Hardie, Judith Thomas, Julie Li, Christopher Pearce, A. Georgiou
Summary: This study used an Action Research approach to identify the benefits and barriers of telehealth use in general practice. The findings revealed a range of barriers that impact general practice but also provided justification for the continuation and development of telehealth.
Review
Health Care Sciences & Services
Andrew Georgiou, Julie Li, Rae-Anne Hardie, Nasir Wabe, Andrea R. Horvath, Jeffrey J. Post, Alex Eigenstetter, Robert Lindeman, Que Lam, Tony Badrick, Christopher Pearce
Summary: Diagnostic investigations aim to increase certainty of disease presence or absence, support clinical management, and monitor patient trajectory. Digital health plays a crucial role in the diagnostic process, enhancing information transfer accuracy and timeliness, and decision-making effectiveness.
FRONTIERS IN DIGITAL HEALTH
(2021)
Review
Computer Science, Information Systems
Peter J. Gates, Rae-Anne Hardie, Magdalena Z. Raban, Ling Li, Johanna Westbrook
Summary: While some studies suggest that EMS can reduce prescribing error rates, the quality of evidence on their effectiveness in reducing medication errors and associated harm is variable. More research is needed to understand the most effective mechanisms for improving medication safety and design features that facilitate new error risks.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Computer Science, Information Systems
Meredith Makeham, Lisa Pont, Carlijn Verdult, Rae-Anne Hardie, Magdalena Z. Raban, Rebecca Mitchell, Helen Purdy, Martina Teichert, Andrew Ingersoll, Johanna I. Westbrook
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2020)
