Article
Pharmacology & Pharmacy
Manal Ali Buabeid, Hafiza Sidra Yaseen, Muhammad Asif, Ghulam Murtaza, El-Shaimaa A. Arafa
Summary: This study evaluates the anti-inflammatory and anti-angiogenic potential of Moringa olifera extract and Moringa-loaded nanoclay films. The results show that Moringa has anti-inflammatory and anti-angiogenic effects, indicating its therapeutic potential against chronic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Gian Marco Leone, Katia Mangano, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone
Summary: Due to the important role of TNF-alpha in immunoinflammatory diseases, TNF-alpha inhibitors have been successfully developed and used in the treatment of autoimmune disorders. Currently, there are five approved anti-TNF-alpha drugs and biosimilars available. This review discusses the historical development, current and potential future applications, as well as the search for biomarkers to predict responsiveness to these therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Lijuan Fu, Lujuan Xing, Yuejing Hao, Ziyi Yang, Shuang Teng, Lanlan Wei, Wangang Zhang
Summary: Xuanwei ham crude peptides (XHP) exhibited anti-inflammatory effects by inhibiting the secretion of inflammatory mediators through regulating inflammation-related signaling pathways, with specific peptide sequences showing higher anti-inflammatory capacity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Jin-Huang Shen, Yi-Fan Zhang, Li Zhang, Na-Na Yang, Xin-Hua Ma, Tian-Hua Zhong, Yong-Hong Zhang
Summary: Chukrasia tabularis, an economically important tree widely cultivated in southeast China, has been found to possess significant anti-inflammatory properties, with limonin compounds identified as the potential active ingredients responsible for this effect.
FOOD SCIENCE & NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Marwa Ben-Khemis, Dan Liu, Coralie Pintard, Zhuoyao Song, Margarita Hurtado-Nedelec, Jean-Claude Marie, Jamel El-Benna, Pham My-Chan Dang
Summary: TNF alpha disrupts IL-10 signaling by inducing STAT3 dephosphorylation through a NOX2-ROS-Lyn-SHP1 axis in human monocytes, leading to prolonged inflammation. These findings explain the poor efficacy of IL-10 therapy in patients with inflammatory diseases and suggest that anti-TNF alpha agents and SHP1/2 inhibitors could improve the therapeutic use of IL-10.
Article
Biotechnology & Applied Microbiology
Manal Buabeid, El-Shaimaa A. Arafa, Hafiza Sidra Yaseen, Muhammad Ihtisham Umar, Ghulam Murtaza
Summary: This study evaluated the anti-inflammatory and antiangiogenic properties of simvastatin and its nanofilms containing silver nanoparticles. The results showed that simvastatin has significant anti-inflammatory and antiangiogenic effects, and can effectively reduce edema. These findings are important for the field of biomedicine, but further clinical studies are needed to validate their commercial use.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Silvia Marino, Nicole Hannemann, Ryan T. Bishop, Feier Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Baeuerle, Slobodan Vukicevic, Marielle Auberval, Patrick Mollat, Aline Bozec, Aymen I. Idris
Summary: TRAF6 inhibitors may be beneficial in managing the inflammatory component of bone disorders, but they may not provide protection against local or systemic bone loss unless combined with anti-resorptive therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Maryam Teimouri, Masoud Homayouni-Tabrizi, Arezoo Rajabian, Hamed Amiri, Hossein Hosseini
Summary: This study found through systematic review and meta-analysis that resveratrol can significantly decrease serum levels of CRP and TNF-alpha in patients with CVDs.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Saeideh Sadat Shobeiri, Mohammadreza Dashti, Safoora Pordel, MohammadAli Rezaee, Navideh Haghnavaz, Malihe Moghadam, Bahareh Ansari, Mojtaba Sankian
Summary: The study showed that low doses of anti-TNF-alpha ssDNA aptamer significantly reduced psoriasis induced by IMQ, and also decreased mRNA levels of IL-17A, STAT3, and S100a9 in the psoriasis model.
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Anjali Chandra, Brian J. Miller, David R. Goldsmith
Summary: Given the evidence suggesting immune dysregulation as a factor in the development of schizophrenia, anti-inflammatory agents have shown promise as adjunctive treatments. Previous meta-analyses have indicated small-to-medium effect sizes in favor of anti-inflammatory agents, although there are challenges in interpreting the results. Factors such as geography, trial duration, sample size, and study quality score were found to predict the effectiveness of anti-inflammatory agents in reducing psychopathology scores. However, caution should be exercised due to concerns of publication bias and the lack of association with other demographic variables.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cell Biology
Breno Picin Casagrande, Luciana Pellegrini Pisani, Debora Estadella
Summary: The study found that consuming an obesogenic diet can decrease AMPK phosphorylation in the hippocampus, but does not increase serum inflammation. However, OD withdrawal leads to increased inflammatory markers in both serum and hippocampus, as well as higher AMPK phosphorylation in the hippocampus.
INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Fang-fang Dai, Min Hu, Yu-wei Zhang, Rong-hui Zhu, Li-ping Chen, Zhi-dian Li, Yan-jie Huang, Wei Hu, Yan-xiang Cheng
Summary: This study reviewed the effects of TNF-alpha disorder on pathological conditions during pregnancy and summarized the impact of anti-TNF-alpha drugs on adverse pregnancy outcomes. Intrauterine growth restriction, spontaneous abortion, and preterm birth were found to be the most common adverse pregnancy outcomes associated with anti-TNF-alpha drugs.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Simin Feng, Minghui Sui, Dan Wang, Christos Ritzoulis, Mohamed A. Farag, Ping Shao
Summary: The study showed that nano-embedded stigmasterol based on zein and pectin could alleviate colitis in mice by reducing adverse physiological symptoms, preventing colon shortening, and inhibiting the NF-kappa B signaling pathway. The addition of pectin increased the stability of the nanoparticles and improved the therapeutic effect. Future research is needed to investigate the efficacy of nano-embedded stigmasterol in humans.
Article
Biochemistry & Molecular Biology
Tomasz Powrozek, Dominika Pigon-Zajac, Marcin Mazurek, Michael Ochieng Otieno, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study aimed to evaluate the impact of inflammatory conditions on the expression of long non-coding RNAs (lncRNAs) in a mouse skeletal muscle cell line. Three lncRNAs (Gm4117, Ccdc41os1, and 5830418P13Rik) were found to be significant in inflammatory-related myotube atrophy. The expression of lncRNAs varied depending on the concentration of the inflammatory factor and the treatment time. Bioinformatics analysis identified potential target genes and miRNAs for these lncRNAs, further implicating their involvement in molecular processes related to muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
