Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Interpretation of Association Signals and Identification of Causal Variants from Genome-wide Association Studies

(2010) Kai Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

(2010) Kristin L. Bigos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Confirmed rare copy number variants implicate novel genes in schizophrenia

(2010) Gloria W.C. Tam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lithium modulates cortical excitability in vitro

(2010) Charlotte Butler-Munro et al.   BRAIN RESEARCH

KCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKspotassium channel

(2010) Junko Kurokawa et al.   Channels

KCNQ1/KCNE1 assembly, co-translation not required

(2010) Carlos G. Vanoye et al.   Channels

Gene Expression Profiling in Rodent Models for Schizophrenia

(2010) Jessica E. Van Schijndel et al.   Current Neuropharmacology

Mining recent brain proteomic databases for ion channel phosphosite nuggets

(2010) Oscar Cerda et al.   JOURNAL OF GENERAL PHYSIOLOGY

Protein Phosphatase 2A and Glycogen Synthase Kinase 3 Signaling Modulate Prepulse Inhibition of the Acoustic Startle Response by Altering Cortical M-Type Potassium Channel Activity

(2010) D. Kapfhamer et al.   JOURNAL OF NEUROSCIENCE

CACNA1C (rs1006737) is associated with schizophrenia

(2010) M Nyegaard et al.   MOLECULAR PSYCHIATRY

Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties

(2010) Sulayman D. Dib-Hajj et al.   NEUROSCIENCE LETTERS

GSA-SNP: a general approach for gene set analysis of polymorphisms

(2010) Dougu Nam et al.   NUCLEIC ACIDS RESEARCH

i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study

(2010) K. Zhang et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states

(2010) K. Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strong synaptic transmission impact by copy number variations in schizophrenia

(2010) J. T. Glessner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Case–case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

(2010) David Curtis et al.   PSYCHIATRIC GENETICS

Proteomic analysis highlights the molecular complexities of native Kv4 channel macromolecular complexes

(2010) Céline Marionneau et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gating and permeation of kainate receptors: differences unveiled

(2010) David Perrais et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

(2010) Michael A. Siuta et al.   PLOS BIOLOGY

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Mysterious α6-containing nAChRs: function, pharmacology and pathophysiology

(2009) Ke-chun Yang et al.   ACTA PHARMACOLOGICA SINICA

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

RNA editing and its impact on GABAAreceptor function

(2009) Chammiran Daniel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

EGAN: exploratory gene association networks

(2009) Jesse Paquette et al.   BIOINFORMATICS

Evolution of the Human Ion Channel Set

(2009) Surendra Nayak et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future

(2009) Maaike Alaerts et al.   HUMAN MUTATION

Noradrenergic Depression of Neuronal Excitability in the Entorhinal Cortex via Activation of TREK-2 K+Channels

(2009) Zhaoyang Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABAB-activated GIRK channels in Purkinje cells

(2009) Laura Fernández-Alacid et al.   JOURNAL OF NEUROCHEMISTRY

Alternative Splicing in the Voltage-Gated Sodium Channel DmNav Regulates Activation, Inactivation, and Persistent Current

(2009) Wei-Hsiang Lin et al.   JOURNAL OF NEUROPHYSIOLOGY

Domain General Mechanisms of Perceptual Decision Making in Human Cortex

(2009) T. C. Ho et al.   JOURNAL OF NEUROSCIENCE

A genome-wide survey of human short-term memory

(2009) A Papassotiropoulos et al.   MOLECULAR PSYCHIATRY

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

(2009) E K Green et al.   MOLECULAR PSYCHIATRY

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

(2009) Stephen J Huffaker et al.   NATURE MEDICINE

Gene set-based analysis of polymorphisms: finding pathways or biological processes associated to traits in genome-wide association studies

(2009) Ignacio Medina et al.   NUCLEIC ACIDS RESEARCH

Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels

(2009) Shuiping Dai et al.   PHYSIOLOGICAL REVIEWS

The Genetic Structure and History of Africans and African Americans

(2009) S. A. Tishkoff et al.   SCIENCE

A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia

(2009) Anna C. Need et al.   PLoS Genetics

Shifting Paradigm of Association Studies: Value of Rare Single-Nucleotide Polymorphisms

(2008) Ivan P. Gorlov et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways

(2008) Lina Chen et al.   BIOINFORMATICS

Voltage-Gated Sodium Channels in Neurological Disorders

(2008) Mohamed Chahine et al.   CNS & Neurological Disorders-Drug Targets

Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission

(2008) Kathleen Askland et al.   HUMAN GENETICS

Extending genome-wide association studies to copy-number variation

(2008) S. A. McCarroll   HUMAN MOLECULAR GENETICS

Antipsychotic-Like Effect of Retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic Acid Ester], a KCNQ Potassium Channel Opener, via Modulation of Mesolimbic Dopaminergic Neurotransmission

(2008) F. Sotty et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alternative translation initiation further increases the molecular and functional diversity of ion channels

(2008) Eric Honoré   JOURNAL OF PHYSIOLOGY-LONDON

Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS

(2008) Henrik H. Hansen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Profiling the Phospho-status of the BKCaChannel α Subunit in Rat Brain Reveals Unexpected Patterns and Complexity

(2008) Jiusheng Yan et al.   MOLECULAR & CELLULAR PROTEOMICS

Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder

(2008) T G Schulze et al.   MOLECULAR PSYCHIATRY

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk

(2008) V Moskvina et al.   MOLECULAR PSYCHIATRY

Whole-genome association study of bipolar disorder

(2008) P Sklar et al.   MOLECULAR PSYCHIATRY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

(2008) Manuel A R Ferreira et al.   NATURE GENETICS

A structural link between inactivation and block of a K+ channel

(2008) Christian Ader et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calcium Channel Regulation and Presynaptic Plasticity

(2008) William A. Catterall et al.   NEURON

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Coregulation of genes in the mouse brain following treatment with clozapine, haloperidol, or olanzapine implicates altered potassium channel subunit expression in the mechanism of antipsychotic drug action

(2008) Carlotta E. Duncan et al.   PSYCHIATRIC GENETICS

A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels

(2008) Olga Fedorenko et al.   PSYCHOPHARMACOLOGY

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

(2008) T. Walsh et al.   SCIENCE

3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors

(2008) A JENSEN et al.   TRENDS IN PHARMACOLOGICAL SCIENCES