Review
Biochemistry & Molecular Biology
Jeong A. Park
Summary: Diffuse alveolar hemorrhage is a life-threatening pulmonary complication with unclear pathogenesis and controversial treatment options, including the off-label use of FVIIa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Alyssa M. Loecher, Kathleen West, Timothy D. Quinn, Aubrey A. Defayette
Summary: DAH is a critical complication that can occur in patients post-HSCT, with treatment options including corticosteroids, aminocaproic acid, and rFVIIa. Further research is needed to explore the efficacy of these treatments for improved outcomes.
Article
Medicine, General & Internal
Daniel Laxar, Eva Schaden, Marion Wiegele, Konrad Hoetzenecker, Stefan Schwarz, Johannes Gratz
Summary: This study investigates the effect of rFVIIa on bleeding in lung transplant patients undergoing ECMO therapy. Results show that only 14% of rFVIIa administrations were effective in controlling bleeding, while 71% of patients required surgery for bleeding control. Although 84% of recommended preconditions were fulfilled, their fulfillment was not associated with rFVIIa efficacy. The incidence of thromboembolic events after rFVIIa administration was comparable to patients not receiving rFVIIa.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yotam Kolben, Fares Darawshy, Barhoum Barhoum, Avraham Abutbul, Rottem Kuint
Summary: G-CSF, commonly used in healthy adults prior to stem cell donation, can lead to rare but life-threatening pulmonary adverse events such as diffuse alveolar hemorrhage. Healthcare providers should be aware of this potential complication.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Critical Care Medicine
Zhenmei Zhang, Can Wang, Steve G. Peters, William J. Hogan, Shahrukh K. Hashmi, Mark R. Litzow, Mrinal S. Patnaik, Alexander S. Niven, Hemang Yadav
Summary: DAH after HCT has a low incidence rate but high mortality rate, requiring attention. Multiple factors may influence the incidence rate, mortality rate, and risk factors, including time of onset, platelet count, and the need for invasive mechanical ventilation. For treatment outcomes, lower doses of steroids may help improve patient survival.
Article
Otorhinolaryngology
Timothy J. Shin, Fahad Hasnain, Elizabeth O. Shay, Michael J. Ye, Bruce H. Matt, Alhasan N. Elghouche
Summary: This study evaluated the use of nebulized tranexamic acid (TXA) in the treatment of post-tonsillectomy hemorrhage (PTH) and its association with rates of operative intervention. A retrospective cohort study was conducted on adult and pediatric patients diagnosed with PTH in 2015-2022 who were treated with nebulized TXA and standard care. The results showed that treatment with nebulized TXA was associated with lower rates of operative intervention and repeat bleeding events. Further prospective studies are needed to confirm the efficacy and optimal treatment protocols. Level of evidence: 3.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2023)
Article
Immunology
Zhongnan Yang, Lei Yan, Huixia Cao, Yue Gu, Pan Zhou, Mingyue Shi, Guodong Li, Xiaojing Jiao, Na Li, Xiangnan Li, Kai Sun, Fengmin Shao
Summary: The study showed that erythropoietin (EPO) can alleviate diffuse alveolar hemorrhage (DAH) by reducing macrophage recruitment and promoting phenotype switch, suggesting its potential as a therapeutic agent for DAH. Further research is needed to validate the direct target of miR-494-3p in regulating JAK2/STAT3 signaling transduction.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Respiratory System
Biplab K. Saha, Woon H. Chong
Summary: Diffuse alveolar hemorrhage is a rare condition with diverse etiologies, where cardiac diseases are often underestimated causes, particularly heart failure and mitral valve diseases being the most common. DAH is typically caused by the stress failure of pulmonary capillaries due to pulmonary venous hypertension, with a contribution from the bronchial circulation.
Article
Immunology
Haoyang Zhuang, Shuhong Han, Li Lu, Westley H. Reeves
Summary: Serp-1 can prevent pristane-induced lung hemorrhage by enhancing LXR-regulated M2 macrophage polarization and KLH4-regulated IL-10 production, offering a potential new therapy for this severe complication of SLE.
CLINICAL IMMUNOLOGY
(2021)
Article
Otorhinolaryngology
Dylan Z. Erwin, Philip D. Heichel, Laura M. Wright, Nira A. Goldstein, Timothy P. McEvoy, Marisa A. Earley, Andrew D. Meyer
Summary: Treating PTH with nebulized TXA may be a safe first-line therapy to reduce the need for operative control of bleeding. The data suggests that a large clinical trial is needed to determine the efficacy of nebulized TXA in mitigating this common and potentially fatal post-operative complication.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Akhilesh Kumar, Maya Gopalakrishnan, Harshavardhan R. Kuri, Archana Bajpayee, Nikhil Kothari, Mahendra Kumar Garg
Summary: This case report highlights an uncommon presentation of delayed pulmonary hemorrhage after snakebite envenoming. The patient showed initial venom-induced consumption coagulopathy followed by diffuse alveolar hemorrhage (DAH), which was successfully treated with immunosuppressants and plasma exchange. Although persistent hypofibrinogenemia was observed, the patient remained healthy during the follow-up period.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Pediatrics
Lucas Hamrick, Seth J. Deskins, Saif Al-Qatarneh
Summary: A 15-year-old female patient presented with symptomatic anemia, fatigue, dyspnea, and weight loss, which were later diagnosed as systemic lupus erythematosus. She developed respiratory failure and bilateral pleural effusions during her hospital admission, but her symptoms improved with treatment.
PEDIATRIC PULMONOLOGY
(2023)
Article
Emergency Medicine
Lei Zhang, Lina Liu, Caiwei Lin, Xudong Wang
Summary: Diffuse alveolar hemorrhage (DAH) is a serious disease with main symptoms of hemoptysis and dyspnea, and ECMO can provide oxygenation support when mechanical ventilation fails. Early initiation of V-V ECMO can rescue patients' lives.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jonathan Du Toit, Maurice Salama, Howard Gluckman, Katalin Nagy
Summary: This article provides an overview of the history and current status of submerging roots for ridge preservation, and presents a detailed protocol for managing submerged roots at single tooth sites and short-span edentulous areas.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Immunology
Xieling He, Li Jiang, Longyuan Hu, Pei Du, Ming Zhu, Haijing Wu, Ming Zhao, Qianjin Lu
Summary: The study found that Mivebresib effectively protected mice against pristane-induced diffuse alveolar hemorrhage (DAH) caused by systemic lupus erythematosus (SLE). It inhibited the migration and polarization of monocytes and macrophages, as well as pathogenic B and T cells. In addition, Mivebresib inhibited M1 polarization of macrophages and the expression of pro-inflammatory cytokines, suggesting its potential as a treatment for DAH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Emergency Medicine
Mohammed S. Alshahrani, Amal H. AlSulaibikh, Mohamed R. ElTahan, Sukayna Z. AlFaraj, Laila P. Asonto, Abdullah A. AlMulhim, Murad F. AlAbbad, Nisreen Almaghraby, Mohammed A. AlJumaan, Thamir O. AlJunaid, Moath N. Darweesh, Faisal M. AlHawaj, Alaa M. Mahmoud, Bader K. Alossaimi, Shaikhah K. Alotaibi, Talal M. AlMutairi, Duaa A. AlSulaiman PharmD, Dunya Alfaraj, Reem Alhawwas, Lawrence Mbuagbaw, Kim Lewis, Madeleine Verhovsek, Mark Crowther, Gordon Guyatt, Waleed Alhazzani
Summary: This study evaluated the efficacy and safety of single-dose ketamine infusion in adults with sickle cell disease (SCD) who presented with acute sickle vasoocclusive crisis (VOC). The results showed that early use of ketamine resulted in a significant reduction in pain scores over a 2-hour period and reduced the cumulative morphine dose in the emergency department. Additionally, there were no significant drug-related side effects in the ketamine-treated group.
ACADEMIC EMERGENCY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yaseen Arabi, Sara Aldekhyl, Saad Al Qahtani, Hasan M. Al-Dorzi, Sheryl Ann Abdukahil, Jesna Jose, Mohammad Khulaif Al Harbi, Husain Al Haji, Mohammed Al Mutairi, Omar Al Zumai, Eman Al Qasim, Wedyan Al Wehaibi, Mohammed Alshahrani, Talal Albrahim, Ahmed Mady, Ali Al Bshabshe, Zohair Al Aseri, Zainab Al Duhailib, Ayman Kharaba, Rakan Alqahtani, Haifa Algethamy, Omar Alfaris, Omar Alnafel, Abdulrahman A. Al-Fares, Haytham Tlayjeh
Summary: This is a multicenter randomized controlled trial on helmet noninvasive ventilation for COVID-19 patients. The trial aims to compare the impact of helmet noninvasive ventilation with usual care on the 28-day mortality rate. As of now, 252 patients have been enrolled.
Article
Public, Environmental & Occupational Health
Waleed Alhazzani, Mohammed Alshahrani, Fayez Alshamsi, Ohoud Aljuhani, Khalid Eljaaly, Samaher Hashim, Rakan Alqahtani, Doaa Alsaleh, Zainab Al Duhailib, Haifa Algethamy, Tariq Al-Musawi, Thamir Alshammari, Abdullah Alqarni, Danya Khoujah, Wail Tashkandi, Talal Dahhan, Najla Almutairi, Haleema A. Alserehi, Maytha Al-Yahya, Bandar Al-Judaibi, Yaseen M. Arabi, Jameel Abualenain, Jawaher M. Alotaibi, Ali Al Bshabshe, Reham Alharbi, Fahad Al-Hameed, Alyaa Elhazmi, Reem S. Almaghrabi, Fatma Almaghlouth, Malak Abedalthagafi, Noor Al Khathlan, Faisal A. Al-Suwaidan, Reem F. Bunyan, Bandar Baw, Ghassan Alghamdi, Manal Al Hazmi, Yasser Mandourah, Abdullah Assiri, Mushira Enani, Maha Alawi, Reem Aljindan, Ahmed Aljabbary, Abdullah Alrbiaan, Fahd Algurashi, Abdulmohsen Alsaawi, Thamer H. Alenazi, Mohammed A. Alsultan, Saleh A. Alqahtani, Ziad Memish, Jaffar A. Al-Tawfiq, Ahmed Al-jedai
Summary: The Saudi Critical Care Society (SCCS) formed a panel of experts to issue evidence-based recommendations for the management of COVID-19 in the intensive care unit. They used the GRADE approach and evidence-to-decision framework to assess the quality of evidence and generate recommendations. The panel issued 12 recommendations on pharmacotherapeutic interventions for severe and critical COVID-19.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Critical Care Medicine
Joanna C. Dionne, Lawrence Mbuagbaw, John W. Devlin, Matthew S. Duprey, Rodrigo Cartin-Ceba, Jennifer Tsang, Kristen Sullivan, John Muscedere, Mohammed Alshahrani, Wojciech Szczeklik, Paul Lysecki, Alyson Takaoka, Brenda Reeve, Tracy Campbell, Karolina Borowska, Wojciech Serednicki, Robert Cirone, Waleed Alhazzani, Paul Moayyedi, David Armstrong, Lehana Thabane, Roman Jaeschke, Cindy Hamielec, Tim Karachi, Deborah J. Cook
Summary: The study revealed a high incidence of diarrhea in ICU patients, with 73.8% affected. Independent predictors of diarrhea included enteral nutrition, antibiotic usage, and suppositories. Diarrhea may prompt changes in patient care.
INTENSIVE CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Waleed Alhazzani, Ken Kuljit S. Parhar, Jason Weatherald, Zainab Al Duhailib, Mohammed Alshahrani, Abdulrahman Al-Fares, Sarah Buabbas, Sujith Cherian, Laveena Munshi, Eddy Fan, Fahad Al-Hameed, Jamal Chalabi, Amera A. Rahmatullah, Erick Duan, Jennifer L. Y. Tsang, Kimberley Lewis, Francois Lauzier, John Centofanti, Bram Rochwerg, Sarah Culgin, Katlynne Nelson, Sheryl Ann Abdukahil, Kirsten M. Fiest, Henry T. Stelfox, Haytham Tlayjeh, Maureen O. Meade, Dan Perri, Kevin Solverson, Daniel J. Niven, Rachel Lim, Morten Hylander Moller, Emilie Belley-Cote, Lehana Thabane, Hani Tamim, Deborah J. Cook, Yaseen M. Arabi
Summary: A study on nonintubated adult patients with acute hypoxemia and COVID-19 found that prone positioning did not significantly reduce the rate of endotracheal intubation within 30 days compared to usual care without prone positioning.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Hasan M. Al-Dorzi, Abdulaziz Al-Dawood, Fahad M. Al-Hameed, Karen E. A. Burns, Sangeeta Mehta, Jesna Jose, Sami Alsolamy, Sheryl Ann Abdukahil, Lara Y. Afesh, Mohammed S. Alshahrani, Yasser Mandourah, Ghaleb A. Almekhlafi, Mohammed Almaani, Ali Al Bshabshe, Simon Finfer, Zia Arshad, Imran Khalid, Yatin Mehta, Atul Gaur, Hassan Hawa, Hergen Buscher, Hani Lababidi, Abdulsalam Al Aithan, Yaseen M. Arabi
Summary: This study evaluated the effect of adjunctive use of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients with HF. The results showed that the use of adjunctive IPC compared with control was associated with similar rate of incident DVT and ventilator-free days in critically ill patients with HF.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Faisal Alonaizan, Jehan AlHumaid, Reem AlJindan, Sumit Bedi, Heba Dardas, Dalia Abdulfattah, Hanadi Ashour, Mohammed AlShahrani, Omar Omar
Summary: This study aimed to determine the agreement between SARS-CoV-2 fluorescent detection and rRT-PCR, using different swab methods. The results showed that the combined O/N/S swab had the highest sensitivity, and using multiple swabs for sampling improved the consistency of the detection.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Mohammed S. Alshahrani, Dunya Alfaraj, Jehan AlHumaid, Khalid Alshahrani, Aisha Alsubaie, Nasser Almulhim, Dana Althawadi, Salah Alam, Malak Alzahrani, Hassan Alwosibai, Abdullah Alshahrani, Rawan Makhdom, Faisal Alkhadra, Sukayna Al-faraj, Saad Al-Qahtani, Amal AlSulaibikh, Mohammed Al Jumaan, Laila Perlas Asonto, Sarah Alahmadi, Mohannad Alghamdi, Mohammed Al-Mulhim
Summary: The COVID-19 pandemic has led to decreased and delayed hospital visits for non-COVID-19-related emergencies, resulting in impact on patient outcomes. Delayed presentation was associated with significantly higher 28-day mortality.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Alyaa Elhazmi, Awad Al-Omari, Hend Sallam, Hani N. Mufti, Ahmed A. Rabie, Mohammed Alshahrani, Ahmed Mady, Adnan Alghamdi, Ali Altalaq, Mohamed H. Azzam, Anees Sindi, Ayman Kharaba, Zohair A. Al-Aseri, Ghaleb A. Almekhlafi, Wail Tashkandi, Saud A. Alajmi, Fahad Faqihi, Abdulrahman Alharthy, Jaffar A. Al-Tawfiq, Rami Ghazi Melibari, Waleed Al-Hazzani, Yaseen M. Arabi
Summary: The study utilized a decision tree algorithm to examine the association between ICU outcomes and a predefined set of variables in adult COVID-19 patients. The decision tree algorithm was found to be useful in predicting 28-day ICU outcomes, providing assistance for critical decision-making by bedside physicians.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Afnan J. Alshrefy, Rawaa N. Alwohaibi, Shahad A. Alhazzaa, Reema A. Almaimoni, Latifah AlMusailet, Shaya Y. AlQahtani, Mohammed S. Alshahrani
Summary: Secondary bacterial and fungal infections are common among COVID-19 patients admitted to the ICU, with a predominance of gram-negative bacteria and Candida species. The development of secondary infections is significantly associated with invasive mechanical ventilation. Poor clinical outcomes have been observed, including prolonged hospital and ICU stays and higher mortality.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Critical Care Medicine
Hassan M. Alshaqaq, Abdulaziz M. Al-Sharydah, Mohammed S. Alshahrani, Saad M. Alqahtani, Marwa Amer
Summary: An updated systematic review and meta-analysis of ten studies found that the clinical efficacy of prophylactic inferior vena cava (IVC) filters in trauma patients for preventing pulmonary embolism (PE) remains uncertain. Observational studies showed a reduction in PE and fatal PE risk, while randomized controlled trials did not yield significant results. Therefore, current evidence does not support routine use of prophylactic IVC filters.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Infectious Diseases
Wala Alkhalifa, Hassan Alhawaj, Aisha Alamri, Fatimah Alturki, Mohammed Alshahrani, Amani Alnimr
Summary: The aim of this study was to describe the frequency of candidemia cases, distribution of Candida spp., and the associated risk factors for mortality in an academic institution in Saudi Arabia. The study found that independent risk factors for mortality in candidemia patients included age, COVID-19 co-infection, and use of tocilizumab. A high rate of antifungal resistance was also observed, highlighting the importance of accurate laboratory testing.
INFECTION AND DRUG RESISTANCE
(2023)
Letter
Medicine, General & Internal
Mohammed S. Alshahrani
SAUDI JOURNAL OF MEDICINE & MEDICAL SCIENCES
(2022)
Article
Respiratory System
Kimberley Lewis, Sarah Culgin, Roman Jaeschke, Dan Perri, Corry Marchildon, Kelly Hassall, Yousef Almubarak, Wojciech Szczeklik, Thomas Piraino, Lehana Thabane, Khaled M. Alqahtani, Abdulazez Alghamdi, Mohammed Alshahrani, Waleed Alhazzani
Summary: The COMIC pilot trial supports the feasibility of a larger trial to determine the impact of CLT on reintubation and clinically significant stridor.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, General & Internal
Yaseen M. Arabi, Haytham Tlayjeh, Sara Aldekhyl, Hasan M. Al-Dorzi, Sheryl Ann Abdukahil, Mohammad Khulaif Al Harbi, Husain Al Haji, Mohammed Al Mutairi, Omar Al Zumai, Eman Al Qasim, Wedyan Al Wehaibi, Saad Al Qahtani, Fahad Al-Hameed, Jamal Chalabi, Mohammed Alshahrani, Talal Albrahim, Abdulrahman Alharthy, Ahmed Mady, Abdulhadi Bin Eshaq, Ali A. Al Bshabshe, Zohair Al Aseri, Zainab Al Duhailib, Ayman Kharaba, Rakan Alqahtani, Adnan Al Ghamdi, Ali Altalag, Khalid Alghamdi, Mohammed Almaani, Haifa Algethamy, Ahmad Al Aqeily, Faisal Al Baseet, Hashem Al Samannoudi, Mohammed Al Obaidi, Yassin T. Ismaiel, Abdulrahman A. Al-Fares
Summary: This study compares the effectiveness of helmet NIV with usual care alone in reducing mortality in patients with COVID-19 pneumonia. A total of 320 patients will be enrolled, with the primary outcome being 28-day all-cause mortality.
