Article
Medicine, Research & Experimental
Suh-Young Lee, Sun-Sin Kim, So-Hee Lee, Heung-Woo Park
Summary: This study found an association between chronic viral hepatitis infection and decreased lung function, specifically in smokers. Non-invasive measurement of hepatic fibrosis may be useful in predicting rapid lung function decline in smokers with chronic viral hepatitis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Genetics & Heredity
B. Liv Gansmo, A. Benedicte Lie, Marthe T. Maehlen, Lars Vatten, Pal Romundstad, Kristian Hveem, Per E. Lonning, Stian Knappskog
Summary: The study found a potential association between the MDM2 del1518 variant and the risk of rheumatoid arthritis, as well as indications that combinational genotypes and haplotypes in the MDM2 locus may be related to rheumatoid arthritis.
Article
Critical Care Medicine
Nadia N. Hansel, Han Woo, Kirsten Koehler, Amanda Gassett, Laura M. Paulin, Neil E. Alexis, Nirupama Putcha, Wendy Lorizio, Ashraf Fawzy, Daniel Belz, Coralynn Sack, R. Graham Barr, Fernando J. Martinez, MeiLan K. Han, Prescott Woodruff, Cheryl Pirozzi, Robert Paine, Igor Barjaktarevic, Christopher B. Cooper, Victor Ortega, Marina Zusman, Joel D. Kaufman
Summary: Indoor particulate matter and nitrogen dioxide are associated with lung function decline among smokers, especially former smokers. Former smokers living in homes with high PM levels have accelerated lung function loss, while those in homes with low PM levels have lung function loss similar to normal aging.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Oncology
Sheng-Kai Liang, Li-Hsin Chien, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Yuh-Min Chen, Ming-Shyan Huang, Hsien-Chih Lin, Wen-Tsen Fang, Hsiao-Han Hung, Shih-Sheng Jiang, Chih-Yi Chen, Kuan-Yu Chen, I-Shou Chang, Chao A. Hsiung, Chien-Jen Chen, Pan-Chyr Yang
Summary: This study identified novel SNPs of programed death ligand 2 associated with lung adenocarcinoma risk in never-smoking women. Two of these SNPs were found to be associated with pulmonary tuberculosis infection in relation to lung adenocarcinoma susceptibility. These SNPs may help in stratifying high-risk populations of never-smokers during lung cancer screening.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Anna Andrzejczak, Anna Partyka, Andrzej Wisniewski, Irena Porebska, Konrad Pawelczyk, Kuba Ptaszkowski, Piotr Kusnierczyk, Monika Jasek, Lidia Karabon
Summary: This study aimed to analyze the impact of BTLA polymorphic variants on the susceptibility to non-small cell lung cancer (NSCLC) and NSCLC patients' overall survival (OS). The results showed that the rs1982809 variant within the BTLA gene is associated with NSCLC risk. Furthermore, BTLA polymorphic variants are associated with smoking history, gender, tumor type, and disease stage in NSCLC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Divay Chandra, Rachel F. Bogdanoff, Russell P. Bowler, Kambez H. Benam
Summary: Adding menthol flavoring to e-liquid increases the number of aerosolized particles, similar to the effect of adding vitamin E acetate. The use of menthol flavored ECs is associated with reduced lung function indices.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Marek Lommatzsch, Timotheus Speer, Christian Herr, Rudolf A. Joerres, Henrik Watz, Achim Mueller, Tobias Welte, Claus F. Vogelmeier, Robert Bals
Summary: This study systematically analyzed the relationship between serum IgE levels and disease characteristics in COPD patients. The results suggest that IgE may play a role in specific subgroups of COPD patients and is associated with the risk of lung function decline.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Min-Ae Song, Kellie M. Mori, Joseph P. Mcelroy, Jo L. Freudenheim, Daniel Y. Weng, Sarah A. Reisinger, Theodore M. Brasky, Mark D. Wewers, Peter G. Shields
Summary: Smoking and electronic cigarette vaping are associated with accelerated lung epigenetic aging, indicating potential adverse effects on biological aging. Further research is needed to understand the unique effects of electronic cigarettes on pulmonary health.
CLINICAL EPIGENETICS
(2023)
Article
Critical Care Medicine
Aravind A. Menon, Rachel K. Putman, Jason L. Sanders, Takuya Hino, Akinori Hata, Mizuki Nishino, Auyon J. Ghosh, Samuel Y. Ash, Ivan O. Rosas, Michael H. Cho, David A. Lynch, George R. Washko, Edwin K. Silverman, Hiroto Hatabu, Gary M. Hunninghake
Summary: The presence of interstitial lung abnormalities (ILAs) attenuates the reduction in forced vital capacity (FVC) associated with emphysema. However, there is no interaction between ILAs and emphysema on total lung capacity or diffusing capacity of carbon monoxide.
Article
Oncology
Elyse R. Park, Sarah E. Skurla, Grelda Yazmin Juarez Caballero, Emily R. Friedman, Colin Ponzani, Robert Wallace, Jennifer Malin, Nancy L. Keating
Summary: This study examined the smoking rates and factors associated with continued smoking among lung and colorectal cancer survivors during long-term follow-up. The findings revealed that a significant proportion of lung and colorectal cancer survivors continued to smoke combustible cigarettes even after a long period of survivorship. Factors such as being male, younger, not married or partnered, having certain types of insurance, experiencing more depression symptoms, smoking more cigarettes per day, and having a history of lung disease were independently associated with continued smoking. These findings have implications for the development of tobacco treatment programs for cancer patients and survivors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Public, Environmental & Occupational Health
Remi Valter, Ophelie Guyonvarch, Ingrid Allagbe, Anne-Laurence Le Faou
Summary: The study aimed to explore factors associated with one-month abstinence in dual users compared to exclusive smokers in French smoking cessation services (SCS). The results showed that dual users had similar cessation rates as exclusive smokers, but presented more comorbidities and higher nicotine dependence levels. Predictors of abstinence in dual users included employment or retirement, multiple previous quit attempts, low nicotine dependence, high motivation to quit, and regular follow-up consultations. The findings suggest that dual users seeking help in SCS can benefit from support to achieve abstinence, despite their higher nicotine dependence and comorbidities. Further qualitative research is needed to provide tailored interventions for this specific group of smokers.
PREVENTIVE MEDICINE
(2023)
Article
Rheumatology
Ahmad Ramahi, Alain Lescoat, David Roofeh, Vivek Nagaraja, Rajaie Namas, Suiyuan Huang, John Varga, David O'Dwyer, Bonnie Wang, Kevin Flaherty, Ella Kazerooni, Dinesh Khanna
Summary: The aim of this study was to identify risk factors of percent predicted forced vital capacity (ppFVC) decline in patients with SSc-associated interstitial lung disease (SSc-ILD). The study analyzed the pulmonary function test results of 312 SSc-ILD patients and found that longer disease duration, ILD extent >20%, and anti-topoisomerase I (ATA) positivity were significantly associated with ppFVC decline. Among these factors, ATA positivity showed the strongest correlation with ppFVC decline.
Article
Environmental Sciences
Sai Li, Gang Wang, Yishuo Geng, Wei Wu, Xiaoli Duan
Summary: This study revealed the susceptibility of allergic rhinoconjunctivitis (ARC) patients to air pollution and found an association between short-term particulate matter (PM) exposure and decreased lung function. The study also found that patients with higher IgE levels were more susceptible to the effects of PM on lung function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Respiratory System
Ilona E. Kammerl, Sophie Hardy, Claudia Flexeder, Andrea Urmann, Julia Peierl, Yuqin Wang, Oliver Vosyka, Marion Frankenberger, Katrin Milger, Juergen Behr, Andrea Koch, Juliane Merl-Pham, Stefanie M. Hauck, Charles Pilette, Holger Schulz, Silke Meiners
Summary: This study found that smoking and COPD can affect the function of immunoproteasomes in peripheral immune cells, leading to their activation. Activated immunoproteasomes were observed in COPD patients and were significantly correlated with reduced lung function. Inhibition of immunoproteasomes reduced pro-inflammatory cytokine expression in immune cells from COPD patients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Geriatrics & Gerontology
Kai Triebner, Dinh Bui, Eugene Haydn Walters, Michael J. Abramson, Gayan Bowatte, Brittany Campbell, Payam Dadvand, Bircan Erbas, David P. Johns, Benedicte Leynaert, Caroline J. Lodge, Adrian J. Lowe, Jennifer L. Perret, Steinar Hustad, Francisco Gomez Real, Shyamali C. Dharmage
Summary: The study found that women with poor lung function in childhood experience a more pronounced decline in lung function after menopause, especially within the lowest tertile of childhood lung function. These findings offer new insights into respiratory health during reproductive aging and underscore the importance of holistic public health strategies covering the entire lifespan.
Article
Ophthalmology
Graham A. Wilson, Kirsten Cheyne, Sandhya Ramrakha, Antony Ambler, Gavin S. W. Tan, Avshalom Caspi, Ben Williams, Karen Sugden, Renate Houts, Rachael L. Niederer, Tien Yin Wong, Terrie E. Moffitt, Richie Poulton
Summary: This study investigated whether macular drusen in midlife are associated with accelerated biological ageing. The results showed no significant association between macular drusen and the pace of ageing or facial ageing.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Multidisciplinary Sciences
Richie Poulton, Hayley Guiney, Sandhya Ramrakha, Terrie E. Moffitt
Summary: This article reflects on the work of the Dunedin Study researchers over the past 50 years and provides insights into future developments. It highlights the historical roots and principles that have contributed to their success, as well as showcasing impactful research in the behavioral, oral health, and respiratory domains. The challenges faced during the study and how they were overcome are also discussed. The article emphasizes the importance of acknowledging and appreciating the contribution of the study participants and their families.
JOURNAL OF THE ROYAL SOCIETY OF NEW ZEALAND
(2023)
Article
Psychology, Clinical
Wendy S. Slutske, Leah S. Richmond-Rakerd, Thomas M. Piasecki, Sandhya Ramrakha, Richie Poulton, Terrie E. Moffitt, Avshalom Caspi
Summary: This study found that childhood precursors (social class, general intelligence, self-control) predicted lifelong disordered gambling, which in turn predicted negative outcomes in adulthood. Adjusting for childhood precursors weakened these associations.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Roy Lay-Yee, Timothy Matthews, Terrie Moffitt, Richie Poulton, Avshalom Caspi, Barry Milne
Summary: This study examines the relationship between social isolation and mental health outcomes in mid-adulthood. The findings suggest that adult-only social isolation is associated with suicide, depression, and suicide ideation, while child-only social isolation is only associated with depression. Persistent child-adult social isolation is closely related to depression in mid-adulthood.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Cell Biology
Daniel J. J. Simpson, Qian Zhao, Nelly N. N. Olova, Jan Dabrowski, Xiaoxiao Xie, Eric Latorre-Crespo, Tamir Chandra
Summary: Recent studies have shown that epigenetic rejuvenation can be achieved through the use of drugs that mimic calorie restriction and techniques such as reprogramming-induced rejuvenation. Mouse models are the safest option for testing rejuvenation in vivo. However, the performance of recent epigenetic clocks developed for mouse reduced-representation bisulphite sequencing (RRBS) data is significantly poor when applied to external datasets.
Article
Psychology, Clinical
Line C. Gjerde, Espen Moen Eilertsen, Tom A. McAdams, Rosa Cheesman, Terrie E. Moffitt, Avshalom Caspi, Thalia C. Eley, Espen Roysamb, Tom H. Rosenstrom, Eivind Ystrom
Summary: This study investigated the joint factor structure of psychopathology and personality in eight-year-old children. The results showed that correlations between normative and pathological traits mostly reflect one heritable and psychometrically interpretable factor. Furthermore, the association between the factor and low gestational age indicates the need for further study of early developmental mechanisms.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Psychology, Clinical
Line C. Gjerde, Espen Moen Eilertsen, Tom A. McAdams, Rosa Cheesman, Terrie E. Moffitt, Avshalom Caspi, Thalia C. Eley, Espen Roysamb, Tom H. Rosenstroem, Eivind Ystrom
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Joanne B. Newbury, Louise Arseneault, Terrie E. Moffitt, Candice L. Odgers, Laura D. Howe, Ioannis Bakolis, Aaron Reuben, Andrea Danese, Karen Sugden, Benjamin Williams, Line J. H. Rasmussen, Antonella Trotta, Antony P. Ambler, Helen L. Fisher
Summary: Children exposed to socioenvironmental adversities are more likely to develop subclinical psychotic experiences during adolescence. This association is partly explained by cognitive ability and inflammation.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Juan J. Madrid-Valero, Timothy Matthews, Nicola L. Barclay, Candice L. Odgers, Terrie E. Moffitt, Avshalom Caspi, Louise Arseneault, Alice M. Gregory
Summary: Research findings on the association between digital technology use and poor sleep quality in adolescence and young adulthood have been mixed. This study used a genetically informative twin design to investigate this association, finding that adolescents' perceived problematic use of technology is associated with poor sleep quality, even after controlling for familial factors. The study also revealed a substantial genetic correlation between problematic use of technology and sleep quality.
Article
Genetics & Heredity
Sally Martin, Daniel Poppe, Nelly Olova, Conor O'Leary, Elena Ivanova, Jahnvi Pflueger, Jennifer Dechka, Rebecca K. K. Simmons, Helen M. M. Cooper, Wolf Reik, Ryan Lister, Ernst J. J. Wolvetang
Summary: DNA methylation is directly related to neuronal genome regulation and maturation. Mouse ESC-derived neurons could recapitulate the in vivo mCH levels over a similar time period. This enables them to be used as a model system to study epigenome maturation over development.
Article
Psychology, Clinical
Avshalom Caspi, Renate M. M. Houts, Helen L. L. Fisher, Andrea Danese, Terrie E. E. Moffitt
Summary: Over the past decade, there has been a growing interest in the general factor of psychopathology, p. This paper reviews the history of the idea that all mental disorders share something in common, p, and how it is often confused with the bifactor model. The authors utilize data from the Environmental Risk Longitudinal Twin Study to examine different statistical representations of p and find that its performance remains consistent regardless of the modeling approach. They suggest that instead of focusing on statistical models, future research should aim to conduct criterion-validation studies and develop new measurement approaches to understand what all mental disorders have in common.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Ophthalmology
Ashleigh Barrett-Young, Wickliffe C. Abraham, Carol Y. Cheung, Jesse Gale, Sean Hogan, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Terrie E. Moffitt, Sandhya Ramrakha, Yih Chung Tham, Graham A. Wilson, Tien Yin Wong, Ahmad R. Hariri, Richie Poulton
Summary: This study investigates the association between retinal neuronal measurements and structural brain measurements in a middle-aged population-based cohort. The findings suggest that the thinner retinal neuronal layers are associated with older brain age and increased risk for later Alzheimer's disease, indicating that the retina may serve as an early biomarker of brain health.
Article
Psychology, Multidisciplinary
Espen Roysamb, Terrie E. Moffitt, Avshalom Caspi, Eivind Ystrom, Ragnhild Bang Nes
Summary: The major sources of worldwide variability in subjective well-being (SWB) include genetic factors, individual environmental exposures, and shared environments. The worldwide heritability of SWB is estimated to be around 31% to 32%, while individual environmental factors explain 46% to 52% of the variance, and shared environments account for 16% to 23% of the global variance in SWB. Unlike previous within-country studies, this research reveals a significant effect of shared environments, which extends beyond families to a national level.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2023)