Journal
HUMAN GENETICS
Volume 124, Issue 5, Pages 557-559Publisher
SPRINGER
DOI: 10.1007/s00439-008-0581-x
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Funding
- Grant-in-Aid from the American Heart Association (FT)
- George O'Brien Kidney Research Center [P50 DK061597]
- Genzyme Renal Innovation Program (FT)
- Satellite Healthcare (FT)
- NIH [P01 HL45522]
- SOLAR [R01 MH59490]
- National Center for Research Resources [UL1 RR025767, KL2 RR025766]
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The aim of this study is to examine whether the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms of the renin-angiotensin system (RAS) genes are associated with cardiovascular and renal-related risk factors in Mexican Americans. Study participants (N = 848) were genotyped by Taqman assays. Association analyses were performed by measured genotype approach. Of the phenotypes examined, the ACE-I/D, AGT-M235T, and AT1RA1166C polymorphisms exhibited signifi/cant association with systolic blood pressure, glomerular filtration rate and body mass index, respectively. The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease.
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