Biosafety Features of Lentiviral Vectors

Targeted lentiviral vectors pseudotyped with the Tupaia paramyxovirus glycoproteins

(2012) T Enkirch et al.   GENE THERAPY

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations

(2012) Daniela Cesana et al.   JOURNAL OF CLINICAL INVESTIGATION

Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts

(2012) Arianna Moiani et al.   JOURNAL OF CLINICAL INVESTIGATION

Safer, Silencing-Resistant Lentiviral Vectors: Optimization of the Ubiquitous Chromatin-Opening Element through Elimination of Aberrant Splicing

(2012) S. Knight et al.   JOURNAL OF VIROLOGY

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia

(2012) Dirk Heckl et al.   MOLECULAR THERAPY

Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

(2012) Julia D Suerth et al.   MOLECULAR THERAPY

A TLR and Non-TLR Mediated Innate Response to Lentiviruses Restricts Hepatocyte Entry and Can be Ameliorated by Pharmacological Blockade

(2012) Judith Agudo et al.   MOLECULAR THERAPY

Lentiviral Vectors Displaying Modified Measles Virus gp Overcome Pre-existing Immunity in In Vivo-like Transduction of Human T and B Cells

(2012) Camille Lévy et al.   MOLECULAR THERAPY

Preclinical Safety and Efficacy of Human CD34+ Cells Transduced With Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome

(2012) Samantha Scaramuzza et al.   MOLECULAR THERAPY

Lentiviral Transduction of CD34+ Cells Induces Genome-Wide Epigenetic Modifications

(2012) Yoshiaki Yamagata et al.   PLoS One

Measles Virus Glycoprotein-Based Lentiviral Targeting Vectors That Avoid Neutralizing Antibodies

(2012) Sabrina Kneissl et al.   PLoS One

Multiple roles of the capsid protein in the early steps of HIV-1 infection

(2012) Ariberto Fassati   VIRUS RESEARCH

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice

(2011) C. Frecha et al.   BLOOD

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

(2011) A. Biffi et al.   BLOOD

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells

(2011) T. Maetzig et al.   BLOOD

Risk assessment in skin gene therapy: viral–cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors

(2011) D Almarza et al.   GENE THERAPY

Pseudotype-Independent Nonspecific Uptake of Gammaretroviral and Lentiviral Particles in Human Cells

(2011) Christine Voelkel et al.   HUMAN GENE THERAPY

Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer

(2011) K Pike-Overzet et al.   LEUKEMIA

Solving the Problem of γ-Retroviral Vectors Containing Long Terminal Repeats

(2011) Derek A Persons et al.   MOLECULAR THERAPY

Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming

(2011) Eva Warlich et al.   MOLECULAR THERAPY

Ex vivo gene transfer and correction for cell-based therapies

(2011) Luigi Naldini   NATURE REVIEWS GENETICS

Properties and functions of the nucleocapsid protein in virus assembly

(2011) Delphine Muriaux et al.   RNA Biology

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

(2011) Karen E. Ocwieja et al.   PLoS Pathogens

A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells

(2010) S. Zhou et al.   BLOOD

Correction of β-thalassemia major by gene transfer in haematopoietic progenitors of pediatric patients

(2010) Emanuela Anna Roselli et al.   EMBO Molecular Medicine

Entry kinetics and cell-cell transmission of surface-bound retroviral vector particles

(2010) Lee S. O'Neill et al.   JOURNAL OF GENE MEDICINE

Effect of the Internal Promoter on Insertional Gene Activation by Lentiviral Vectors with an Intact HIV Long Terminal Repeat

(2010) S. Knight et al.   JOURNAL OF VIROLOGY

Nuclear RNA Export and Packaging Functions of HIV-1 Rev Revisited

(2010) M. Blissenbach et al.   JOURNAL OF VIROLOGY

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK

(2010) Y Y Ng et al.   LEUKEMIA

LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

(2010) Rik Gijsbers et al.   MOLECULAR THERAPY

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

(2010) Stefan Stein et al.   NATURE MEDICINE

Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome

(2010) Kaan Boztug et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Hematopoietic Stem Cell-Specific miRNAs Enables Gene Therapy of Globoid Cell Leukodystrophy

(2010) B. Gentner et al.   Science Translational Medicine

Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS

(2009) M A Zanta-Boussif et al.   GENE THERAPY

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

(2009) Eugenio Montini et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element

(2009) Hideki Hanawa et al.   MOLECULAR THERAPY

Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region

(2009) Paritha I Arumugam et al.   MOLECULAR THERAPY

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

(2009) Ute Modlich et al.   MOLECULAR THERAPY

Genomic and Functional Assays Demonstrate Reduced Gammaretroviral Vector Genotoxicity Associated With Use of the cHS4 Chromatin Insulator

(2009) Chang Long Li et al.   MOLECULAR THERAPY

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

The 3′ Region of the Chicken Hypersensitive Site-4 Insulator Has Properties Similar to Its Core and Is Required for Full Insulator Activity

(2009) Paritha I. Arumugam et al.   PLoS One

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

Lentiviral vectors with measles virus glycoproteins – dream team for gene transfer?

(2009) Christian J. Buchholz et al.   TRENDS IN BIOTECHNOLOGY

HMGA2, MicroRNAs, and Stem Cell Aging

(2008) Scott M. Hammond et al.   CELL

Strategies for Targeting Lentiviral Vectors

(2008) Cecilia Frecha et al.   CURRENT GENE THERAPY

Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells

(2008) B Moreno-Carranza et al.   GENE THERAPY

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional Gene Activation by Lentiviral and Gammaretroviral Vectors

(2008) M. Bokhoven et al.   JOURNAL OF VIROLOGY

Reduced Genotoxicity of Avian Sarcoma Leukosis Virus Vectors in Rhesus Long-term Repopulating Cells Compared to Standard Murine Retrovirus Vectors

(2008) Jingqiong Hu et al.   MOLECULAR THERAPY

Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors

(2008) Daniela Zychlinski et al.   MOLECULAR THERAPY

Stem Cell Marking With Promotor-deprived Self-inactivating Retroviral Vectors Does Not Lead to Induced Clonal Imbalance

(2008) Kerstin Cornils et al.   MOLECULAR THERAPY

Stable knockdown of microRNA in vivo by lentiviral vectors

(2008) Bernhard Gentner et al.   NATURE METHODS

Combinatorial Incorporation of Enhancer-Blocking Components of the Chicken β-Globin 5′HS4 and Human T-Cell Receptor α/δ BEAD-1 Insulators in Self-Inactivating Retroviral Vectors Reduces Their Genotoxic Potential

(2008) Ali Ramezani et al.   STEM CELLS

Replication-competent retrovirus vectors for cancer gene therapy

(2007) Chien-Kuo Tai   Frontiers in Bioscience-Landmark