Article
Clinical Neurology
William C. Walker, Sarah W. Clark, Kaleb Eppich, Elisabeth A. Wilde, Aaron M. Martin, Chelsea M. Allen, Melissa M. Cortez, Mary Jo Pugh, Samuel R. Walton, Kimbra Kenney
Summary: This study analyzed the relationship between lifetime history of mild traumatic brain injury (mTBI) and other factors with headache prevalence and impact among combat-exposed current and former service members. The results showed that regardless of the remoteness of mTBI, participants with positive mTBI history had higher headache prevalence and impact. Blast-related mTBI posed the highest risk and was uniquely associated with elevated headache burden. Other demographic and potentially modifiable risk factors were also identified.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
Nicholas S. Race, Katharine D. Andrews, Elizabeth A. Lungwitz, Sasha M. Vega Alvarez, Timothy R. Warner, Glen Acosta, Jiayue Cao, Kun-han Lu, Zhongming Liu, Amy D. Dietrich, Sreeparna Majumdar, Anantha Shekhar, William A. Truitt, Riyi Shi
Summary: TBI is associated with increased risk for mental health disorders, and deficits in psychosocial processing may contribute to post-TBI mental health issues. A pre-clinical investigation using rats found that a single mild blast TBI induced impairment of psychosocial processing in the absence of other confounding factors, and this impairment may be related to acute upregulations of an oxidative stress metabolite.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chidozie C. Anyaegbu, Harrison Szemray, Sarah C. Hellewell, Nathan G. Lawler, Kerry Leggett, Carole Bartlett, Brittney Lins, Terence McGonigle, Melissa Papini, Ryan S. Anderton, Luke Whiley, Melinda Fitzgerald
Summary: Mild traumatic brain injury (mTBI) can cause structural, cellular, and biochemical changes in the brain that are difficult to detect and may persist chronically. Lipidomic analysis of blood samples, which can easily cross the blood-brain barrier, may provide valuable insights into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to analyze plasma lipid concentrations after 11 days of sham, one (1 x), or two (2 x) mTBI in rats. They identified 18 lipid species that distinguished between different injury conditions and found that the changes in lipid concentrations varied depending on the number of mTBI, suggesting a balance of damage and reparative responses.
Article
Clinical Neurology
Faith W. Akin, Owen D. Murnane, Courtney D. Hall, Kristal M. Riska, Jennifer Sears
Summary: The purpose of this study was to assess vestibular and balance function in individuals with chronic dizziness associated with mTBI/blast. The findings show significant differences between the case group and the control group in saccadic accuracy, VOR gain, vestibular evoked myogenic potentials asymmetry ratio, sensory organization test score, Dynamic Gait Index score, and gait. Abnormalities in vestibular, ocular motor, and balance/gait testing were observed in participants with mTBI/blast, with the most frequent abnormalities occurring in tests of balance and gait function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jean-Nicolas Tourigny, Valerie Boucher, Veronique Paquet, Emile Fortier, Christian Malo, Eric Mercier, Jean-Marc Chauny, Gregory Clark, Pierre-Gilles Blanchard, Pierre-Hugues Carmichael, Jean-Luc Gariepy, Myreille D'Astous, Marcel Emond
Summary: The study validated the sensitivity and specificity of the updated BIG in predicting the need for interhospital transfer in patients with complicated mild traumatic brain injury. The results showed that patients in the uBIG-1 group could be safely managed at their initial center without the need for transfer.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Article
Neurosciences
Scott D. McDonald, William C. Walker, Shannon E. Cusack, Ruth E. Yoash-Gantz, Treven C. Pickett, David X. Cifu, Larry A. Tupler
Summary: This study found that, even after adjusting for various factors, deployment-related mild traumatic brain injury (mTBI) during OEF/OIF/OND was still associated with several persistent post-concussive symptoms (PPCSs), including headaches, sleep disturbance, and difficulty making decisions. In addition, deployment-related mTBI was also linked to symptoms not commonly associated with mTBI, such as nausea/upset stomach and numbness/tingling.
Article
Neurosciences
Caroline A. Browne, Hildegard A. Wulf, Moriah L. Jacobson, Mario G. Oyola, T. John Wu, Irwin Lucki
Summary: Neurobehavioral deficits can emerge in patients after a mild traumatic brain injury (TBI) and nearly half of them may experience these deficits for months. Ketamine, commonly used as an anesthetic/analgesic, may have beneficial effects on patients with a history of TBI, but caution should be exercised due to potential impairing effects. Studies on mice showed that sensitivity to ketamine increased in mice after TBI, suggesting caution should be taken when using ketamine in TBI patients.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Xuan Li, Xiaoyan Jia, Yuling Liu, Guanghui Bai, Yizhen Pan, Qiuyu Ji, Zhaoyi Mo, Wenpu Zhao, Yixin Wei, Shan Wang, Bo Yin, Jie Zhang, Lijun Bai
Summary: Traumatic brain injury disrupts the coordinated activity of the triple network and produces impairments across several cognitive domains. This study used brain network interaction index and dynamic functional connectivity to examine the time-varying cross-network interactions among the triple network in patients with mild TBI. The findings suggest that increased and more variable cross-network interactions are associated with more severe and multiple domains of cognitive impairments in mild TBI.
Article
Behavioral Sciences
Chandni Sheth, Jadwiga Rogowska, Margaret Legarreta, Erin McGlade, Deborah Yurgelun-Todd
Summary: The study revealed increased connectivity between the ACC and other brain regions in Veterans with mTBI, consistent with previous research findings. This may explain enhanced top-down control networks to compensate for microstructural damage post-mTBI.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Clinical Neurology
Justin K. Zhang, Kathleen S. Botterbush, Kazimir Bagdady, Chi Hou Lei, Philippe Mercier, Tobias A. Mattei
Summary: This study provides an overview of thermobaric weapons and their potential to cause blast-related traumatic brain injury (bTBI). It also highlights the long-term cognitive and neuropsychiatric sequelae following bTBI and discusses diagnostic, therapeutic, and rehabilitation strategies. The findings aim to guide mitigation strategies and humanitarian relief in Ukraine.
WORLD NEUROSURGERY
(2022)
Article
Pediatrics
Xenophon Sinopidis, Panagiotis Kallianezos, Constantinos Petropoulos, Despoina Gkentzi, Eirini Kostopoulou, Sotirios Fouzas, Theodore Dassios, Aggeliki Vervenioti, Ageliki Karatza, Stylianos Roupakias, Antonios Panagidis, Evangelos Blevrakis, Eleni Jelastopulu
Summary: This study aims to evaluate the stress of children with mild head injuries and their parents' relevant perception during the early post-traumatic period. Results showed that 33.7% of children and 19.0% of parents were diagnosed with stress after one week, and 9.9% of children and 3.9% of parents after one month. It indicates that mild head injuries can have an impact on the emotional well-being of children and should not be overlooked.
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Neurosciences
Jill Daugherty, Kelly Sarmiento, Matthew Breiding
Summary: This study examines how the wording of questions can influence the reporting of traumatic brain injury (TBI). The results show that a greater percentage of respondents reported a lifetime history of concussion compared to mild TBI, suggesting that the terminology used can impact reporting.
Article
Psychology, Clinical
Audreyana Jagger-Rickels, Anna Stumps, David Rothlein, Hannah Park, Francesca Fortenbaugh, Agnieszka Zuberer, Jennifer R. Fonda, Catherine B. Fortier, Joseph DeGutis, William Milberg, Regina McGlinchey, Michael Esterman
Summary: This study explores the relationship between PTSD symptoms severity, brain functioning, and cognition, finding a link between reduced negative coupling in certain brain networks and impaired executive function in individuals with PTSD. The results suggest that poor executive functioning may represent a neurocognitive subtype of PTSD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Catherine B. Fortier, Brigitta M. Beck, Kimberly B. Werner, Katherine M. Iverson, Sahra Kim, Alyssa Currao, Jennifer R. Fonda, Tara E. Galovski
Summary: The study aims to adapt the Boston Assessment of TBI-Lifetime (BAT-L) interview for female survivors of intimate partner violence (IPV), validate the adapted BAT-L/IPV, and report the prevalence of head injury. The results show that BAT-L/IPV performed well in diagnosing traumatic brain injuries (TBI) in female IPV survivors.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Nursing
Anna G. Etchin, Jennifer R. Fonda, Elizabeth P. Howard, Catherine B. Fortier, William P. Milberg, Karen Pounds, Regina E. McGlinchey
Summary: This study examines the major deployment and clinical exposures that contribute to reintegration challenges among post-9/11 veterans. The findings suggest that depression severity has the strongest association with reintegration challenges, followed by PTSD severity, post-deployment stress, and deployment safety concerns. Veterans with a history of interpersonal early life trauma (I-ELT) have a stronger association with deployment safety concerns.
Article
Psychology, Clinical
John P. K. Bernstein, Anna Stumps, Francesca Fortenbaugh, Jennifer R. Fonda, Regina E. McGlinchey, William P. Milberg, Catherine B. Fortier, Michael Esterman, Melissa Amick, Joseph DeGutis
Summary: Deployment-related posttraumatic sequelae are associated with increased disability in U.S. veterans deployed following the September 11, 2001 terrorist attacks. However, few studies have examined the psychiatric and somatic variables associated with changes in functional disability over time.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Psychology, Clinical
Colleen E. Jackson, Alyssa Currao, Jennifer R. Fonda, Alexandra Kenna, William P. Milberg, Regina E. McGlinchey, Catherine B. Fortier
Summary: The study utilized a hybrid PTSD diagnostic interview combining DSM-IV and DSM-5 criteria, finding high agreement, sensitivity, specificity, positive predictive value, negative predictive value, and interrater reliability between male and female participants.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Psychology, Clinical
Catherine B. Fortier, Alyssa Currao, Alexandra Kenna, Sahra Kim, Brigitta M. Beck, Dylan Katz, Colleen Hursh, Jennifer R. Fonda
Summary: This study evaluated the safety and feasibility of home-based telemental health group workshops in post-9/11 U.S. military veterans. The results demonstrate the safety, feasibility, and high satisfaction of group telemental health in U.S. veterans, offering convenient and cost-effective care options.
Article
Psychology, Clinical
Anna G. Etchin, Vincent Corbo, Emma Brown, Catherine B. Fortier, Jennifer R. Fonda, William P. Milberg, Alyssa Currao, Regina E. McGlinchey
Summary: Maladaptive anger and aggression are common in US military veterans. Early life adversity predisposes veterans to later life psychopathology, and posttraumatic stress disorder (PTSD) and depression severities have the strongest associations with current veteran anger.
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY
(2022)
Article
Psychology, Clinical
Sahra Kim, Alyssa Currao, Jennifer R. Fonda, Katherine M. Iverson, Alexandra Kenna, Meghan E. Pierce, Brigitta M. Beck, Ricardo E. Jorge, Catherine B. Fortier
Summary: Intimate partner violence (IPV) is prevalent among Veterans, and it increases the risk of head, neck, and face injuries as well as mental health disorders. This study examined the associations between lifetime IPV and health and functioning in post-9/11 Veterans and found that IPV experience was significantly related to TBI, pain, and psychiatric conditions. Additionally, it was found that PTSD, mood disorder, and pain were significantly associated with functional disability, especially in women. The study suggests the need for novel, transdiagnostic treatments for Veterans with a history of IPV.
JOURNAL OF AGGRESSION MALTREATMENT & TRAUMA
(2023)
Article
Clinical Neurology
Joshua A. Adkinson, Evangelia Tsolaki, Sameer A. Sheth, Brian A. Metzger, Meghan E. Robinson, Denise Oswalt, Cameron C. McIntyre, Raissa K. Mathura, Allison C. Waters, Anusha B. Allawala, Angela M. Noecker, Mahsa Malekmohammadi, Kevin Chiu, Richard Mustakos, Wayne Goodman, David Borton, Nader Pouratian, Kelly R. Bijanki
Summary: This study investigates the connectivity between stimulation targets and mood-related networks in psychiatric DBS patients using a multimodal approach. The results demonstrate both similarities and differences between tractography-predicted structural connectivity and stimulation-induced electrophysiological responses, providing new insights for surgical targeting and network-wide effects of neuromodulation.
Article
Engineering, Biomedical
Mahsa Malekmohammadi, Richard Mustakos, Sameer Sheth, Nader Pouratian, Cameron C. McIntyre, Kelly R. Bijanki, Evangelia Tsolaki, Kevin Chiu, Meghan E. Robinson, Joshua A. Adkinson, Denise Oswalt, Stephen Carcieri
Summary: The DBS Illumina 3D algorithm uses patient-specific imaging to assist clinical programming by optimizing stimulation settings to activate a target area while minimizing stimulation of areas outside the target, showing promising clinical application potential.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neuroimaging
Travis C. Evans, Marina Rodriguez Alonso, Audreyana Jagger-Rickels, David Rothlein, Agnieszka Zuberer, John Bernstein, Catherine B. Fortier, Jennifer R. Fonda, Audri Villalon, Ricardo Jorge, William Milberg, Regina McGlinchey, Joseph DeGutis, Michael Esterman
Summary: Posttraumatic stress disorder (PTSD) is associated with dysregulated sustained attention, and previous studies have not distinguished associations between PTSD and sustained attention ability and strategy. This study found that PTSD symptoms were selectively associated with reduced sustained attention ability but not impulsive response strategies. Additionally, both PTSD symptomatology and sustained attention ability were associated with reduced synchronization in the dorsal attention network (DAN) to endogenous attentional fluctuations.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychology, Clinical
Jennifer R. Fonda, Michael L. Crowe, Laura K. Levin, Audreyana Jagger-Rickels, Brian P. Marx, William P. Milberg, Regina E. McGlinchey, Catherine B. Fortier
Summary: This study examined the associations between mild traumatic brain injury (mTBI) and neurobehavioral, psychiatric, and functional disability symptoms among recent-era U.S. veterans. The results showed that mTBI had minimal impact compared to other symptoms and did not affect the connectivity of the symptoms network.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Clinical Neurology
Dora Lendvai, Robin Whittemore, Julie A. Womack, Catherine B. Fortier, William P. Milberg, Jennifer R. Fonda
Summary: This study aimed to explore the associations between blast exposure and metabolic abnormality, as well as the potential mediating effect of comorbid psychological and somatic conditions. The results showed no significant associations between blast exposure and metabolic abnormalities. Future research with larger samples and longer follow-up is needed to further investigate this association.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2023)
Article
Psychology, Clinical
Sahra Kim, Alyssa Currao, John Bernstein, Jennifer R. Fonda, Catherine B. Fortier
Summary: This study examined cognitive functioning in post-9/11 Veterans with the deployment trauma phenotype (DTP), and found that these Veterans had decreased cognitive control/processing speed and episodic memory. The comorbidity of PTSD and depressive disorder also negatively impacted performances in episodic memory. However, mild traumatic brain injury alone did not show any cognitive deficits. Clinical interventions should target psychiatric symptoms and employ a transdiagnostic approach to address this multimorbid population.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Criminology & Penology
Meghan E. Pierce, Catherine Fortier, Jennifer R. Fonda, William Milberg, Regina McGlinchey
Summary: Intimate partner violence (IPV) is found to independently contribute to the severity of posttraumatic stress disorder (PTSD) in both male and female post-9/11 veterans. However, there are gender differences in how different trauma types contribute to PTSD symptom severity. More research is needed to further understand these findings.
JOURNAL OF INTERPERSONAL VIOLENCE
(2022)