Article
Neurosciences
Bochao Cheng, Xiuli Wang, Neil Roberts, Yushan Zhou, Song Wang, Pengcheng Deng, Yajing Meng, Wei Deng, Jiaojian Wang
Summary: Postpartum depression and postpartum depression comorbid with anxiety are common and severe mental health problems in postnatal women. This study used resting-state functional magnetic resonance imaging to investigate the neural mechanisms and potential treatment targets for these conditions, and found specific brain region abnormalities that contribute to understanding and diagnosing these disorders.
Article
Neurosciences
Li-Xia Yuan, Na Zhao, Xiu-Qin Wang, Ya-Ting Lv, Hongjian He
Summary: The study found that local activity metrics display a significant dependency on TE, showing an initial large change followed by a slow variation; different local activity metrics exhibit distinct characteristics with regards to TE; this highlights the importance of carefully considering the impact of TE on data acquisition and multi-center data analysis in RS-fMRI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Qing Chen, Yanmeng Bi, Xiaohua Zhao, Yuqi Lai, Weixin Yan, Lingpeng Xie, Tingting Gao, Shuwen Xie, Ting Zeng, Jun Li, Shanshan Kuang, Lei Gao, Zhiping Lv
Summary: This study investigated abnormalities in spontaneous brain activity in MDD patients, finding that mean ALFF and fALFF could potentially serve as neuroimaging markers to differentiate MDD patients from healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Jifei Sun, Yue Ma, Limei Chen, Zhi Wang, Chunlei Guo, Yi Luo, Deqiang Gao, Xiaojiao Li, Ke Xu, Yang Hong, Xiaobing Hou, Jing Tian, Xue Yu, Hongxing Wang, Jiliang Fang, Xue Xiao
Summary: In this study, the differences in local brain functional activity and its characteristics were observed in patients with treatment-resistant depression (TRD) and non-treatment-resistant depression (nTRD) using amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). The study found that abnormal neurological functional activity was present in some brain regions, and these abnormalities were correlated with clinical symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Juan Yue, Na Zhao, Yang Qiao, Zi-Jian Feng, Yun-Song Hu, Qiu Ge, Tian-Qing Zhang, Zhu-Qian Zhang, Jue Wang, Yu-Feng Zang
Summary: This study tested the reliability and validity of a new functional magnetic resonance imaging (fMRI) metric called Wavelet-ALFF, and applied it to investigate the modulation effect of repetitive transcranial magnetic stimulation (rTMS). The results showed that Wavelet-ALFF had higher reliability and validity compared to the previous metric FFT-ALFF, especially in higher frequency bands. Wavelet db2-ALFF showed the best reliability and validity, suggesting it can be a powerful tool for examining regional spontaneous brain activities in future studies.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Article
Anatomy & Morphology
Toshiki Kusano, Hiroki Kurashige, Isao Nambu, Yoshiya Moriguchi, Takashi Hanakawa, Yasuhiro Wada, Rieko Osu
Summary: Several fMRI studies have shown that resting-state brain activity is comprised of components corresponding to the spatial pattern induced by task performance, with components in motor-related areas corresponding to elementary movements of individual body parts. This suggests that resting-state brain activity may have a finer structure than previously thought.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Nobuko Sakakibara, Kai Makita, Daiki Hiraoka, Ryoko Kasaba, Ryo Kuboshita, Koji Shimada, Takashi X. Fujisawa, Akemi Tomoda
Summary: Mothers with high levels of trait anxiety tend to have less adaptive sensory processing, leading to increased parenting stress. Resting-state neural activity in the left lobule VI of the cerebellum is positively correlated with trait anxiety and parenting stress levels, indicating a potential neural indicator for maternal trait anxiety and risk of parenting stress.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Giuseppe A. Zito, Clement Tarrano, Prasanthi Jegatheesan, Asya Ekmen, Benoit Beranger, Michael Rebsamen, Cecile Hubsch, Sophie Sangla, Cecilia Bonnet, Cecile Delorme, Aurelie Meneret, Bertrand Degos, Floriane Bouquet, Marion Apoil Brissard, Marie Vidailhet, Cecile Gallea, Emmanuel Roze, Yulia Worbe
Summary: This study investigated the resting state functional connectivity in different body representation areas within the motor cortex and cerebellum in cervical dystonia patients. Patients showed increased functional connectivity between bilateral trunk representation area of the motor cortex and cerebellar vermis, which did not correlate with structural changes or symptom severity.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Psychiatry
Irene Neuner, Tanja Veselinovic, Shukti Ramkiran, Ravichandran Rajkumar, Gereon Johannes Schnellbaecher, N. Jon Shah
Summary: Given the diversity and complexity of mental disorders, personalized approaches are the most promising avenue for clinical transfer and establishment of personalized psychiatry. Recent studies using ultra-high-field MRI technology have assessed changes in resting-state network properties in depressed patients during therapy, revealing significant changes and providing new insights.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Fanyu Zhang, Bo Hua, Tengfei Wang, Mei Wang, Zhong Xiang Ding, Ju-Rong Ding
Summary: Growth hormone deficiency (GHD) is a developmental disorder characterized by short stature, slow growth, and cognitive and behavioral abnormalities due to partial or complete deficiency of growth hormone secreted by the pituitary gland. Research shows abnormal brain functional activity in children with GHD, which may explain their abnormal cognition and behavior.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Xinling Chen, Yongbo Xu, Bingjie Li, Xiaoyan Wu, Ting Li, Li Wang, Yijie Zhang, Wanghuan Lin, Chen Qu, Chunliang Feng
Summary: Arginine vasopressin (AVP), a neuropeptide with widespread receptors in brain regions important for socioemotional processing, is critical in regulating various mammalian social behavior and emotion. The study demonstrated that the role of AVP in socioemotional functioning recruits multiple brain networks distributed across the whole brain rather than specific localized neural pathways. This data-driven approach also opens a novel avenue to delineate neural underpinnings of various neuropeptides or hormones.
Article
Neurosciences
Yiyuan Shen, Weiwei Wang, Yin Wang, Liqin Yang, Chengjie Yuan, Yang Yang, Fei Wu, Junlong Wang, Yan Deng, Xu Wang, Hanqiu Liu
Summary: This study investigated the differences in intrinsic functional cerebral activity between chronic ankle instability (CAI) patients and healthy controls (HCs), and explored its correlation with clinical measurement in CAI patients. The results revealed that CAI patients exhibited enhanced regional inherent neuronal activity within the sensorimotor network, while lower activity was observed in pain/emotion modulation related regions. Additionally, information exchanges within the sensorimotor network were stronger, but weaker between distant interhemispheric regions. The increased inherent activity in the right middle frontal gyrus was also related to clinical severity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yuyang Li, Mengqi Zhao, Yuting Cao, Yanyan Gao, Yadan Wang, Bing Yun, Le Luo, Wenming Liu, Chanying Zheng
Summary: Table tennis players showed differences in brain functional connectivity in both static and dynamic states, indicating that long-term table tennis skill training leads to changes in brain activity and network organization.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yu Wang, Yi Lu, Meimei Du, Nimo Mohamed Hussein, Lan Li, Yu Wang, Chuanwan Mao, Tao Chen, Fangfang Chen, Xiaozheng Liu, Zhihan Yan, Yuchuan Fu
Summary: This study found that the lack of direct parental care during early childhood could affect brain function development involving cognition, behavior, and emotion in left-behind children. The findings emphasize the importance of intellectual and emotional care for left-behind children.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Pablo Najt, Fei Wang, Linda Spencer, Jennifer A. Y. Johnston, Elizabeth T. Cox Lippard, Brian P. Pittman, Cheryl Lacadie, Lawrence H. Staib, Xenophon Papademetris, Hilary P. Blumberg
BIOLOGICAL PSYCHIATRY
(2016)
Article
Neurosciences
Elizabeth T. C. Lippard, Carolyn M. Mazure, Jennifer A. Y. Johnston, Linda Spencer, Judah Weathers, Brian Pittman, Fei Wang, Hilary P. Blumberg
JOURNAL OF NEUROSCIENCE RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
E. T. C. Lippard, K. P. Jensen, F. Wang, J. A. Y. Johnston, L. Spencer, B. Pittman, J. Gelernter, H. P. Blumberg
MOLECULAR PSYCHIATRY
(2017)
Article
Psychology, Developmental
Judah Weathers, Elizabeth T. C. Lippard, Linda Spencer, Brian Pittman, Fei Wang, Hilary P. Blumberg
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2018)
Article
Public, Environmental & Occupational Health
Elizabeth T. Cox Lippard, Jennifer A. Y. Johnston, Hilary P. Blumberg
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2014)
Article
Psychiatry
Lingtao Kong, Kaiyuan Chen, Fay Womer, Wenyan Jiang, Xingguang Luo, Naomi Driesen, Jie Liu, Hilary Blumberg, Yanqing Tang, Ke Xu, Fei Wang
JOURNAL OF PSYCHIATRIC RESEARCH
(2013)
Article
Psychiatry
Hu Liu, Yanqing Tang, Fay Womer, Guoguang Fan, Tao Lu, Naomi Driesen, Ling Ren, Ye Wang, Yong He, Hilary P. Blumberg, Ke Xu, Fei Wang
SCHIZOPHRENIA BULLETIN
(2014)
Article
Clinical Neurology
Martha Sajatovic, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Farren B. S. Briggs, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit Mulsant, Sigfried Schouws, Nadine Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Betsy Wilson, Lisa T. Eyler
Summary: Literature on older-age bipolar disorder (OABD) is limited. This study analyzed data from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) and found that mood symptom severity was low among older individuals, but functioning was mildly impaired and associated with age and education level. Depressive symptoms were strongly linked to worse functioning in older individuals, highlighting the importance of effective treatments for BD depression in this population.
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Lejla Colic, Luca Villa, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: Using a whole-brain Intrinsic Connectivity Distribution approach, hubs of brain dysfunction were identified in adolescents and young adults with Bipolar I Disorder, particularly showing higher connectivity in depressed states, which were closely related to mood symptoms and could be potential targets for early intervention.
Editorial Material
Clinical Neurology
Danielle A. Goldman, Hilary P. Blumberg
Article
Clinical Neurology
Laura Montejo, Carla Torrent, Esther Jimenez, Anabel Martinez-Aran, Hilary P. Blumberg, Katherine E. Burdick, Peijun Chen, Annemieke Dols, Lisa T. Eyler, Brent P. Forester, Jennifer R. Gatchel, Ariel Gildengers, Lars Kessing, Kamilla W. Miskowiak, Andrew T. Olagunju, Regan E. Patrick, Sigfried Schouws, Joaquim Radua, Caterina del M. Bonnin, Eduard Vieta
Summary: Through a comprehensive neuropsychological assessment, we found that cognitive dysfunction is present in euthymic older adults with bipolar disorder, with significant deficits in almost all cognitive domains, especially in the memory domain. This highlights the importance of including a routine complete neuropsychological assessment and considering therapeutic strategies for this population.
Article
Clinical Neurology
Katherine E. Burdick, Caitlin E. Millett, Anastasia K. Yocum, Cara M. Altimus, Ole A. Andreassen, Valerie Aubin, Raoul Belzeaux, Michael Berk, Joanna M. Biernacka, Hilary P. Blumberg, Anthony J. Cleare, Claudia Diaz-Byrd, Caroline Dubertret, Bruno Etain, Lisa T. Eyler, Brent P. Forester, Janice M. Fullerton, Mark A. Frye, Sebastien Gard, Ophelia Godin, Emmanuel Haffen, Federica Klaus, Trine Vik Lagerberg, Marion Leboyer, Anabel Martinez-Aran, Susan McElroy, Philip B. Mitchell, Emilie Olie, Phebe Olorunfemi, Christine Passerieux, Amy T. Peters, Daniel L. Pham, Mircea Polosan, Julia R. Potter, Martha Sajatovic, Ludovic Samalin, Raymund Schwan, Megan Shanahan, Brisa Sole, Rebecca Strawbridge, Amanda L. Stuart, Ivan Torres, Torrill Ueland, Eduard Vieta, Lana J. Williams, Anna L. Wrobel, Lakshmi N. Yatham, Allan H. Young, Andrew A. Nierenberg, Melvin G. McInnis
Summary: This study aimed to assess the influence of key factors on community function in multiple well-characterized samples of individuals with bipolar disorder (BD) and found several factors that affect community functioning, such as depressive symptoms, educational level, and number of mood episodes.
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Article
Clinical Neurology
Amulya Mallu, Carol K. Chan, Lisa T. Eyler, Annemiek Dols, Soham Rej, Hilary P. Blumberg, Kaylee Sarna, Brent P. Forester, Regan E. Patrick, Orestes V. Forlenza, Esther Jimenez, Eduard Vieta, Sigfried Schouws, Ashley Sutherland, Joy Yala, Farren B. S. Briggs, Martha Sajatovic
Summary: This study investigates the relationship between occupational status and other characteristics in older adults with bipolar disorder (OABD). The findings suggest that educational level, age, psychiatric severity, and comorbidity are associated with unemployment in this population.