Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Cell Biology
Joseph S. R. Alisch, Nikkita Khattar, Richard W. Kim, Luis E. Cortina, Abinand C. Rejimon, Wenshu Qian, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Summary: Cerebral blood flow varies with age in different brain regions, with white matter regions showing increased blood flow with age and women having higher blood flow than men. The study results provide a foundation for further investigation of CNS perfusion in various scenarios.
Article
Endocrinology & Metabolism
Jan Willem van Dalen, Henri J. M. M. Mutsaerts, Jan Petr, Matthan Wa Caan, Eric P. Moll van Charante, Bradley J. MacIntosh, Willem A. van Gool, Aart J. Nederveen, Edo Richard
Summary: This study found no associations between blood pressure measures and cerebral blood flow, but antihypertensive medication use was associated with lower cerebral blood flow and increased ASL signal heterogeneity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Yusuke Watanabe, Naoyuki Takei, Tsuyoshi Ueyama, Satoru Miyawaki, Satoshi Koizumi, Seiji Kato, Hidemasa Takao, Osamu Abe, Nobuhito Saito
Summary: The study found that in severe steno-occlusive diseases, the Combo strategy using ATT correction can improve CBF measurement accuracy, and VS significantly enhances CBF measurement accuracy in standard protocol and in moyamoya patients for the Combo.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Physiology
Sergio M. Solis-Barquero, Rebeca Echeverria-Chasco, Marta Calvo-Imirizaldu, Elena Cacho-Asenjo, Antonio Martinez-Simon, Marta Vidorreta, Pablo D. Dominguez, Reyes Garcia de Eulate, Miguel Fernandez-Martinez, Maria A. Fernandez-Seara
Summary: A PCASL sequence combined with background suppression and accelerated 3D RARE stack-of-spirals was used to evaluate cerebrovascular reactivity induced by breath-holding in healthy volunteers. The study found that elevated cerebral blood flow was observed in most regions under hypercapnia, with significantly higher values in gray matter compared to white matter.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph G. Woods, Eric C. Wong, Emma C. Boyd, Divya S. Bolar
Summary: In this study, a novel pulse sequence called VESPA ASL is introduced that combines velocity-selective and pseudo-continuous ASL to simultaneously label different pools of arterial blood for robust cerebral blood flow (CBF) and arterial transit time (ATT) measurement. The results show that VESPA ASL accurately measures CBF in the presence of long ATTs, and ATTs < TI can also be measured. VESPA ASL offers important advantages over existing methods for noninvasive perfusion and transit time imaging in vascular diseases with delayed arterial transit.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Diana Kindler, Cinzia Maschio, Ruiqing Ni, Valerio Zerbi, Daniel Razansky, Jan Klohs
Summary: The study found no significant differences in regional cerebral blood flow between P301L mice and non-transgenic littermates at different disease stages, indicating that hypoperfusion and neurodegeneration are not phenotypes of P301L mice. Additional research is needed to further understand the relationship between tau, neurodegeneration, vascular dysfunction, and modulators in Alzheimer's disease and primary tauopathies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Xiao-Hui Wang, Xiao-Fan Liu, Min Ao, Ting Wang, Jinglan He, Yue-Wen Gu, Jing-Wen Fan, Li Yang, Renqiang Yu, Shuliang Guo
Summary: This study aims to explore the cerebral perfusion pattern and blood flow status of anxiety in patients with pulmonary nodules, and found significant differences between the anxiety group and the non-anxiety group. By detecting the cerebral blood flow in specific brain regions, the anxiety group can be accurately distinguished from the non-anxiety group.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neuroimaging
Weizhao Lu, Chunyan Yu, Liru Wang, Feng Wang, Jianfeng Qiu
Summary: This study used a machine learning approach to identify three subtypes of cerebral small vessel disease (CSVD) with distinct patterns of cerebral blood flow (CBF). These subtypes showed significant differences in clinical measurements and imaging phenotypes, highlighting the importance of understanding perfusion alterations in CSVD for precision diagnosis.
NEUROIMAGE-CLINICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyu Wang, Weiqiang Dou, Dong Dong, Xinyi Wang, Xueyu Chen, Kunjian Chen, Huimin Mao, Yu Guo, Chao Zhang
Summary: This study aimed to explore the feasibility of three-dimensional pseudo-continuous arterial-spin-labeling (tASL) in evaluating MCA recanalization. After recanalization, tASL provided good prognosis and was found to be an independent predictor of good clinical outcome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Multidisciplinary Sciences
Patricia Clement, Marco Castellaro, Thomas W. Okell, David L. Thomas, Pieter Vandemaele, Sara Elgayar, Aaron Oliver-Taylor, Thomas Kirk, Joseph G. Woods, Sjoerd B. Vos, Joost P. A. Kuijer, Eric Achten, Matthias J. P. van Osch, John A. Detre, Hanzhang Lu, David C. Alsop, Michael A. Chappell, Luis Hernandez-Garcia, Jan Petr, Henk J. M. M. Mutsaerts
Summary: ASL-BIDS is a standardized method for ASL data storage that can improve the reproducibility and data sharing of ASL research.
Article
Clinical Neurology
Zhen-Gui Xu, Jin-Jing Xu, Jinghua Hu, Yuanqing Wu, Dan Wang
Summary: This study investigated abnormal cerebral blood flow in tinnitus patients and the effects of headache on cerebral blood flow, finding decreased CBF in the auditory and prefrontal cortex of chronic tinnitus patients. Headache may accelerate CBF reductions in tinnitus, forming the neurological mechanism in chronic tinnitus with tension-type headache.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Abir Troudi, Fatima Tensaouti, Eloise Baudou, Patrice Peran, Anne Laprie
Summary: This article introduces the magnetic resonance imaging techniques for pediatric brain tumors, especially the ASL MRI technique in evaluating treatment response and neurocognitive sequelae. ASL is a noninvasive technique for measuring cerebral blood flow, but it has some drawbacks and technical requirements.
Article
Neurosciences
Xiaoshuai Li, Yansheng Zhao, Ying Hui, Yuntao Wu, Qian Chen, Huijing Shi, Han Lv, Mengning Li, Pengfei Zhao, Wenfei Zhang, Xinyu Zhao, Jing Li, Liufu Cui, Zhenchang Wang
Summary: This study assessed the lateralization of cerebral blood flow in the auditory cortex of patients with idiopathic tinnitus and healthy controls using 3D pseudocontinuous arterial spin labeling. The results showed a significant asymmetry in cerebral blood flow between the left and right hemispheres of the auditory cortex in both tinnitus patients and healthy controls. Tinnitus patients exhibited higher cerebral blood flow in the bilateral primary auditory cortex compared to healthy controls, and the severity of tinnitus was positively correlated with cerebral blood flow in the left primary auditory cortex.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Fang Ye, Lei Du, Bing Liu, Xinying Gao, Aocai Yang, Die Liu, Yue Chen, Kuan Lv, Pengfei Xu, Yuanmei Chen, Jing Liu, Lipeng Zhang, Shijun Li, Amir Shmuel, Qi Zhang, Guolin Ma
Summary: This study compared cerebral blood flow using pCASL perfusion imaging in individuals with autism spectrum disorders (ASD) and typically developing children. The results showed that individuals with ASD had reduced cerebral blood flow in certain brain regions, and there were correlations between cerebral blood flow and clinical characteristics/developmental profile.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Danfeng Xie, Yiran Li, Hanlu Yang, Li Bai, Tianyao Wang, Fuqing Zhou, Lei Zhang, Ze Wang
MAGNETIC RESONANCE IMAGING
(2020)
Article
Neurosciences
Aldo Camargo, Ze Wang
Summary: Longitudinal changes in cerebral blood flow (CBF) were observed in both Alzheimer's disease (AD) patients and normal controls (NC), with CBF reductions in areas such as the hippocampus. Stable NC and MCI patients showed different patterns of CBF reduction, with NC-MCI converters and MCI-AD converters exhibiting changes in specific brain regions.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Ze Wang
Summary: The study reveals that resting brain entropy is negatively associated with general functionality in the default mode network (DMN) and executive control network (ECN), independently of age and sex. Furthermore, resting brain entropy in DMN/ECN increases with age but decreases with education years, suggesting it may reflect a latent functional reserve that can be enhanced by education.
Article
Physics, Multidisciplinary
Jue Lu, Ze Wang
Summary: Entropy measures the irregularity and randomness of a dynamic system, while multi-scale entropy analysis, such as MSE, calculates system complexity through sample entropy at different scales. The issue with current MSE algorithm is that SampEn calculations at different scales are based on the same threshold, leading to systematic bias as data standard deviation changes with subsampling scales.
Article
Multidisciplinary Sciences
Shiva Shahrampour, Justin Heholt, Andrew Wang, Faezeh Vedaei, Feroze B. Mohamed, Mahdi Alizadeh, Ze Wang, George Zabrecky, Nancy Wintering, Anthony J. Bazzan, Thomas P. Leist, Daniel A. Monti, Andrew B. Newberg
Summary: The study found that administration of N-acetyl-cysteine (NAC) in patients with multiple sclerosis (MS) led to altered cerebral blood flow (CBF) and improved cognition and attention. This suggests potential clinical impact of NAC in MS patients, warranting further large-scale efficacy studies to determine optimal dosages and differential effects.
Article
Neurosciences
Fan Nils Yang, Tina Tong Liu, Ze Wang
Summary: Sleep disturbance and mental disorders have a bidirectional influence, and a shared neural mechanism between them, specifically involving the default mode network and the dorsal attention network, has been identified in preadolescents. Longitudinal analysis shows that less segregated default mode network and dorsal attention network are associated with negative outcomes on mental well-being and sleep disturbance a year later.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Zhang, Danfeng Xie, Yiran Li, Aldo Camargo, Donghui Song, Tong Lu, Jean Jeudy, David Dreizin, Elias R. Melhem, Ze Wang
Summary: This study evaluated the transferability of a DL-based ASL MRI denoising method across different image sequences and populations, finding that DLASL outperformed traditional methods on different datasets, significantly improving image quality, and enhancing the detection of AD-related hypoperfusion patterns.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Yiran Li, Hanlu Yang, Danfeng Xie, David Dreizin, Fuqing Zhou, Ze Wang
Summary: Recent years have witnessed a growing research interest in replacing the computationally intensive MR image reconstruction process with deep neural networks. The proposed hybrid DL image reconstruction method, combining a state-of-the-art deep learning network with a traditional data reconstruction algorithm, showed superior reconstruction results compared to other state-of-the-art DL-based methods and a traditional compressed sensing method.
APPLIED SCIENCES-BASEL
(2022)
Article
Critical Care Medicine
David Dreizin, Kathryn Champ, Matthew Dattwyler, Uttam Bodanapally, Elana B. Smith, Guang Li, Rohan Singh, Ze Wang, Yuanyuan Liang
Summary: This study compared the performance of computed tomography (CT) volumetry-based quantitative modeling to the 1994 and 2018 AAST Organ Injury Scale and Thompson classifier in determining whether to perform splenectomy or angioembolization for blunt splenic injury. The results showed that the quantitative CT volumetry model was as accurate as the 2018 AAST scoring and significantly better than the Thompson scoring.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Neurosciences
Liandong Lin, Da Chang, Donghui Song, Yiran Li, Ze Wang
Summary: This study investigates the relationship between brain entropy during resting state and brain activations and deactivations during task performance. The results show that lower brain entropy at rest is associated with stronger activations and deactivations in brain regions engaged by the tasks. Higher workload leads to more extensive negative correlations between resting brain entropy and task activations. These findings suggest that resting brain activity can predict task-related brain activity and may facilitate both task activations and deactivations.
Article
Pediatrics
Fan Nils Yang, Weizhen Xie, Ze Wang
Summary: Insufficient sleep has a long-lasting effect on the neurocognitive development of early adolescents, impacting mental health, cognition, brain function, and brain structure. Early sleep intervention is valuable for improving long-term developmental outcomes in children.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Luis Hernandez-Garcia, Veronica Aramendia-Vidaurreta, Divya S. Bolar, Weiying Dai, Maria A. Fernandez-Seara, Jia Guo, Ananth J. Madhuranthakam, Henk Mutsaerts, Jan Petr, Qin Qin, Jonas Schollenberger, Yuriko Suzuki, Manuel Taso, David L. Thomas, Matthias J. P. van Osch, Joseph Woods, Lirong Yan, Ze Wang, Li Zhao, Moss Y. Zhao, Thomas W. Okell
Summary: This review article provides a comprehensive review of recent technical developments in advanced arterial spin labeling (ASL) methods, focusing on readouts and trajectories, image reconstruction, noise reduction, partial volume correction, quantification of nonperfusion parameters, and more. The aim is to enhance understanding and provide guidance for the implementation of these new approaches in research and MRI practice.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neuroimaging
Aldo Camargo, Ze Wang
Summary: This study compared three ASL MRI sequences in AD research and found that the 3D PCASL sequence had greater sensitivity in detecting CBF differences between patients and controls. MCI patients showed reduced CBF and CBF redistribution, and the orbito-frontal cortex exhibited a U-shaped pattern of CBF changes from normal aging to MCI to AD. Furthermore, 3D PCASL and 2D PASL had different correlations with memory-related rCBF.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianpaolo Del Mauro, Ze Wang
Summary: This study examines the relationship between brain entropy (BEN) measured by resting-state fMRI and physiological indices. The results show that respiratory rate (RR) negatively affects BEN, while systolic blood pressure (s-BP) and body mass index (BMI) positively affect BEN. Moreover, after controlling for physiological effects, BEN is still associated with cognitive ability in the fronto-parietal cortex and the sensorimotor system.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Computer Science, Interdisciplinary Applications
Wenyu Jiang, Luhui Cai, Ze Wang
Summary: Substance use disorders are associated with impaired decision making/inhibition control, information processing, and common alterations in frontal and limbic brain areas. A study on marijuana dependence, nicotine dependence, and alcohol dependence found increased brain entropy in these disorders, with overlapping hyper-brain entropy in certain brain regions. Hyper-brain entropy in these areas was correlated with increased impulsivity or reduced inhibition control in substance use disorder, providing a sensitive marker for detecting brain and behavioral alterations.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)