Article
Radiology, Nuclear Medicine & Medical Imaging
Chun Ki Franklin Au, Jill Abrigo, Chunlei Liu, Wanting Liu, Jack Lee, Lisa Wing Chi Au, Queenie Chan, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Ho Ko, Vincent Chung Tong Mok, Weitian Chen
Summary: AD is associated with higher magnetic susceptibility in the fimbria compared with controls. QSM values showed significant differences between the control and early AD groups, and could be used for differentiation, with a model incorporating clinical and radiologic data correctly classifying up to 76% of subjects.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neurosciences
Oliver C. Kiersnowski, Gavin P. Winston, Lorenzo Caciagli, Emma Biondetti, Maha Elbadri, Sarah Buck, John S. Duncan, John S. Thornton, Karin Shmueli, Sjoerd B. Vos
Summary: Using quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*), we investigated brain alterations in patients with temporal lobe epilepsy (TLE) compared to healthy controls (HC). We found significant changes in susceptibility and R2* in various brain regions, indicating selective loss of neurons and iron redistribution in the hippocampi, increased iron content in the thalamus and putamen, and correlations with disease severity and cognitive test scores.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Emma L. Twait, Kim Blom, Huiberdina L. Koek, Maarten H. T. Zwartbol, Rashid Ghaznawi, Jeroen Hendrikse, Lotte Gerritsen, Mirjam I. Geerlings
Summary: This study used high-field 7T MRI to explore the association between psychosocial factors and hippocampal (subfield) volumes. The results showed that depression and anxiety were not associated with specific hippocampal (subfield) volumes, while childhood maltreatment and recent stressful life events may have an impact on hippocampal volume. Additionally, low social support was associated with smaller CA3 volume.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Pierre Wibawa, Mark Walterfang, Charles B. B. Malpas, Yifat Glikmann-Johnston, Govinda Poudel, Adeel Razi, Anthony J. J. Hannan, Dennis Velakoulis, Nellie Georgiou-Karistianis
Summary: This study examined the volumes of hippocampal subfields in individuals with early symptomatic Huntington disease (HD) using T1-weighted MRI. The results showed significantly lower subfield volumes in the symptomatic HD group compared to the pre-symptomatic HD and control groups. These findings suggest the involvement of specific hippocampal subregions in the memory impairment observed in early symptomatic HD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Chia-Ming Shih, Hsin-Chih Lo, Meng-Chi Hsieh, Jyh-Horng Chen
Summary: Functional quantitative susceptibility mapping (fQSM) was introduced in this study to complement BOLD-fMRI in quantitatively assessing local susceptibility and venous oxygen saturation (SvO(2)). Results showed that the susceptibility change of fQSM was four times larger than the BOLD signal change, with more restricted activation responses in the visual pathway compared to BOLD. This study demonstrated the feasibility, sensitivity, and specificity of fQSM, providing quantitative clues and localized information in small animal brains.
Article
Geriatrics & Gerontology
Simon Doran, Daniel Carey, Silvin Knight, James F. Meaney, Rose Anne Kenny, Celine De Looze
Summary: This study examined the relationship between hippocampal subfield volumes and cognitive decline and identified several hippocampal subfields associated with global cognitive decline. The results strengthen the predictive value of hippocampal subfield atrophy in risk of cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neuroimaging
Tales Santini, Minseok Koo, Nadim Farhat, Vinicius P. Campos, Salem Alkhateeb, Marcelo A. C. Vieira, Meryl A. Butters, Caterina Rosano, Howard J. Aizenstein, Joseph Mettenburg, Enrico M. Novelli, Tamer S. Ibrahim
Summary: Individuals with sickle cell disease (SCD) show significantly smaller volume in specific subregions of the hippocampus, such as the Dentate Gyrus and Cornu Ammonis (CA) 2 and 3, compared to healthy controls. This study supports previous findings of reduced temporal lobe volume in SCD patients, suggesting the need for further research on the mechanisms behind structural changes in hippocampal subfields and their impact on cognitive performance in SCD patients.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Jennifer Monereo-Sanchez, Jacobus F. A. Jansen, Sebastian Kohler, Martin P. J. van Boxtel, Walter H. Backes, Coen D. A. Stehouwer, Abraham A. Kroon, Jeroen P. Kooman, Casper G. Schalkwijk, David E. J. Linden, Miranda T. Schram
Summary: The study found that diabetes and different stages of hyperglycemia are associated with tissue volume differences in specific subfields of the hippocampus. This research provides a potential opportunity for early prevention of brain diseases.
NEUROIMAGE-CLINICAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christof Boehm, Sarah Schlaeger, Jakob Meineke, Kilian Weiss, Marcus R. Makowski, Dimitrios C. Karampinos
Summary: This study aims to define effective in-phase echo times based on a multi-peak fat model for quantitative susceptibility mapping (QSM) in water-fat regions. The relationship between fat fraction, field map quantification bias, and susceptibility bias was analyzed. The results show that the proposed effective multi-peak in-phase echoes achieve similar quantitative performance to water-fat separation-based QSM while reducing computational expense for field map estimation.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Sonia Mazzucchi, Eleonora Del Prete, Mauro Costagli, Daniela Frosini, Davide Paoli, Gianmichele Migaleddu, Paolo Cecchi, Graziella Donatelli, Riccardo Morganti, Gabriele Siciliano, Mirco Cosottini, Roberto Ceravolo
Summary: This study evaluated the diagnostic potential of a multimodal MRI protocol combining morphometric and quantitative susceptibility mapping (QSM) imaging in patients with determined parkinsonisms. The results showed that QSM had excellent diagnostic accuracy in distinguishing PD from PSP and good accuracy in distinguishing PD from MSA-p. Combining morphometric imaging and QSM could improve the diagnostic phase of degenerative parkinsonisms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Lawrence Ver Hoef, Hrishikesh Deshpande, Joel Cure, Goutham Selladurai, Julia Beattie, Richard E. Kennedy, Robert C. Knowlton, Jerzy P. Szaflarski
Summary: The study introduces a method called HR-MICRA for consistent high resolution imaging of hippocampal internal architecture on any MRI platform. By averaging scans at different multiples, clear visualization of the hippocampal structure can be achieved in different planes.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Yuto Uchida, Hirohito Kan, Keita Sakurai, Kenichi Oishi, Noriyuki Matsukawa
Summary: This review summarizes the latest advances in the diagnosis and pathological mechanisms of Alzheimer's disease, including the closer association of tau pathology rather than beta-amyloid pathology with the onset and progression of Alzheimer's symptoms, as well as the pathomechanism of altered iron metabolism interacting with abnormal proteins related to AD pathology. The study also investigates the association of cerebral susceptibility values with other pathological biomarkers for AD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Bradley G. Karat, Jordan Dekraker, Uzair Hussain, Stefan Kohler, Ali R. Khan
Summary: This study used diffusion magnetic resonance imaging (dMRI) and a surface-based approach to reveal the microstructural distributions in different subfields of the hippocampus. The neurite density, dispersion, and myelin content varied across the subfields, reflecting the known differences in cellular and myelin architecture. Additionally, the macrostructural measurements were consistent with ex vivo descriptions of hippocampal anatomy. By combining in vivo dMRI with computational approaches, a comprehensive understanding of hippocampal microstructure can be obtained, which is important for cognition and disease diagnosis.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Hyungseok Jang, Sam Sedaghat, Jiyo S. Athertya, Dina Moazamian, Michael Carl, Yajun Ma, Xing Lu, Alicia Ji, Eric Y. Chang, Jiang Du
Summary: This study developed an ultrashort echo time quantitative susceptibility mapping technique with an efficient 3D cones trajectory and validated its effectiveness in the human brain. The results showed that this technique provides reliable estimation of magnetic susceptibility and offers a new biomarker for susceptibility mapping in the in vivo brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Holly Spence, Chris J. McNeil, Gordon D. Waiter
Summary: This study explored the relationship between regional brain iron accumulation and age, cognition in a cohort of individuals from the Aberdeen children of the 1950s cohort. The results showed that while some regions of the brain exhibited associations between iron content and cognitive performance, there was an overall lack of correlation between regional iron content and cognitive ability in cognitively healthy individuals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Christian Thaler, Qiyuan Tian, Max Wintermark, Pejman Ghanouni, Casey H. H. Halpern, Jaimie M. M. Henderson, Raag D. D. Airan, Michael Zeineh, Maged Goubran, Christoph Leuze, Jens Fiehler, Kim Butts Pauly, Jennifer A. McNab
Summary: This study detected microstructural changes within the CTCT after tcMRgFUS treatment and found a correlation between these changes and lesion-tract overlap, which helps to elucidate the treatment mechanism and improve targeting strategies.
BRAIN CONNECTIVITY
(2023)
Article
Clinical Neurology
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Sabrina Adamo, Christopher Scott, Vincent Gaudet, Joel Ramirez, Walter Swardfager, Hugo Cogo-Moreira, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Min Su Kang, Jennifer S. Rabin, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the association between cerebrovascular burden and cognitive function, and found that the relationship was mainly mediated by localized neurodegeneration rather than amyloid beta deposition. The results suggest an amyloid-independent pathway through which vascular burden affects cognitive function.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Ying Meng, Maged Goubran, Jennifer S. Rabin, Melissa McSweeney, Julie Ottoy, Christopher B. Pople, Yuexi Huang, Alexandra Storace, Miracle Ozzoude, Allison Bethune, Benjamin Lam, Walter Swardfager, Chinthaka Heyn, Agessandro Abrahao, Benjamin Davidson, Clement Hamani, Isabelle Aubert, Henrik Zetterberg, Nicholas J. Ashton, Thomas K. Karikari, Kaj Blennow, Sandra E. Black, Kullervo Hynynen, Nir Lipsman
Summary: In this study, the researchers investigated the feasibility and tolerability of opening the blood-brain barrier in the default mode network using MR-guided focused ultrasound in patients with Alzheimer's disease. The intervention resulted in a reduction of local amyloid in PET imaging, but had no effect on disease-specific markers in plasma or CSF. The study highlights the importance of understanding the impact of blood-brain barrier modulation on neurodegenerative diseases and its potential for therapeutic delivery.
Article
Endocrinology & Metabolism
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Jordan A. Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the relationship between A beta-PET signal in white matter (WM) regions and diffusion MRI-based microstructural alterations. The results showed that decreased A beta-PET signal in WMH regions was closely associated with higher free water and higher WMH volume, while increased A beta-PET signal in normal-appearing WM was closely associated with higher cortical A beta and lower free water-adjusted FA. Furthermore, cognitive impairment was more closely related to higher free water than to either free water-adjusted FA or WM PET.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
William S. H. Kim, Xiang Ji, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Fuqiang Gao, Zhongmin Lin, Aravinthan Jegatheesan, Mario Masellis, Maged Goubran, Jennifer S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. Black, Simon J. Graham, Bradley J. MacIntosh
Summary: This study aimed to investigate whether adults who experienced flu-like symptoms due to COVID-19 would exhibit alterations in cerebral blood flow (CBF) in the weeks/months beyond infection. The results showed that the COVID-19 group had significantly decreased CBF in subcortical regions (thalamus, orbitofrontal cortex, and basal ganglia) compared to the control group. Within the COVID-19 group, significant CBF differences in occipital and parietal regions were observed between those with and without self-reported ongoing fatigue.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Jieli Geng, Fuqiang Gao, Joel Ramirez, Kie Honjo, Melissa F. Holmes, Sabrina Adamo, Miracle Ozzoude, Gregory M. Szilagyi, Christopher J. M. Scott, Glen T. Stebbins, David L. Nyenhuis, Maged Goubran, Sandra E. Black
Summary: This study investigates the associations between thalamic volumes and post-stroke cognitive function. The results show that the thalamic volumes on the affected side in stroke patients are smaller compared to the control group, and they are associated with cognitive impairment. These findings suggest that the remote effect of stroke on thalamic volume is correlated with global cognitive impairment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Di Yu, Nuanyi Liang, Julia Zebarth, Qing Shen, Miracle Ozzoude, Maged Goubran, Jennifer S. Rabin, Joel Ramirez, Christopher J. M. Scott, Fuqiang Gao, Robert Bartha, Sean Symons, Seyyed Mohammad Hassan Haddad, Courtney Berezuk, Brian Tan, Donna Kwan, Robert A. Hegele, Allison A. Dilliott, Nuwan D. Nanayakkara, Malcolm A. Binns, Derek Beaton, Stephen R. Arnott, Jane M. Lawrence-Dewar, Ayman Hassan, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Leanne Casaubon, Gustavo Saposnik, Yurika Otoki, Krista L. Lanctot, Mario Masellis, Sandra E. Black, Richard H. Swartz, Ameer Y. Taha, Walter Swardfager
Summary: A study found that cerebral small vessel disease is associated with the ratio of certain fatty acid metabolites, and this association has not been examined in stroke patients before. The study analyzed clinical and imaging data of stroke patients and found that the ratio of these fatty acid metabolites is related to small vessel stroke, white matter hyperintensities, and temporal lobe atrophy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Engineering, Biomedical
Daniel R. R. Allen, Collin Clarke, Terry M. M. Peters, Elvis C. S. Chen
Summary: A Virtual Reality C-Arm simulator was proposed for training in interventional spine procedures, leading to significant improvement in C-Arm placement accuracy and procedure time reduction. The simulator eliminates the exposure to ionizing radiation associated with the current training standard.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Multidisciplinary Sciences
Brian Hsueh, Ritchie Chen, YoungJu Jo, Daniel Tang, Misha Raffiee, Yoon Seok Kim, Masatoshi Inoue, Sawyer Randles, Charu Ramakrishnan, Sneha Patel, Doo Kyung Kim, Tony X. Liu, Soo Hyun Kim, Longzhi Tan, Leili Mortazavi, Arjay Cordero, Jenny Shi, Mingming Zhao, Theodore T. Ho, Ailey Crow, Ai-Chi Wang Yoo, Cephra Raja, Kathryn Evans, Daniel Bernstein, Michael Zeineh, Maged Goubran, Karl Deisseroth
Summary: Emotional states influence bodily physiology, and it is unclear whether an increased heart rate can induce anxiety responses. Using noninvasive optogenetic methods, researchers found that optically induced tachycardia enhances anxiety-like behavior, suggesting that both central and peripheral processes are involved in the development of emotional states.
Article
Clinical Neurology
Miracle Ozzoude, Brenda Varriano, Derek Beaton, Joel Ramirez, Sabrina Adamo, Melissa Holmes, Christopher J. M. Scott, Fuqiang Gao, Kelly Sunderland, Paula McLaughlin, Maged Goubran, Donna Kwan, Angela Roberts, Robert Bartha, Sean Symons, Brian Tan, Richard Swartz, Agessandro Abrahao, Gustavo Saposnik, Mario Masellis, Anthony Lang, Connie Marras, Lorne Zinman, Christen Shoesmith, Michael Borrie, Corinne Fischer, Andrew Frank, Morris Freedman, Manuel Montero-Odasso, Sanjeev Kumar, Stephen Pasternak, Stephen Strother, Bruce Pollock, Tarek Rajji, Dallas Seitz, David Tang-Wai, John Turnbull, Dar Dowlatshahi, Ayman Hassan, Leanne Casaubon, Jennifer Mandzia, Demetrios Sahlas, David A. Breen, David Grimes, Mandar Jog, Thomas D. L. Steeves, Stephen Arnott, Sandra Black, Elizabeth Finger, Jennifer Rabin, Maria Carmela Tartaglia
Summary: White matter hyperintensities and cortical thickness are both associated with neuropsychiatric symptoms, but they contribute differently. Neurodegenerative and cerebrovascular diseases are associated with neuropsychiatric symptoms, with frontotemporal dementia and Parkinson's disease having more severe symptoms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Nathan W. W. Churchill, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Xiang Ji, Fuqiang Gao, Zhongmin Lin, Aravinthan Jegatheesan, Mario Masellis, Maged Goubran, Jennifer S. S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. E. Black, Bradley J. J. MacIntosh, Simon J. J. Graham, Tom A. A. Schweizer
Summary: This cross-sectional observational study aimed to determine if there are significant alterations in resting brain function among non-hospitalized individuals with PACS. The results showed that COVID-19 patients had lower functional connectivity in the brain, and the severity of symptoms was associated with altered functional connectivity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Julia Zebarth, Radia Kamal, George Perlman, Michael Ouk, Lisa Y. Xiong, Di Yu, William Z. Lin, Joel Ramirez, Mario Masellis, Maged Goubran, Bradley J. MacIntosh, Sandra E. Black, Hugo Cogo-Moreira, Christopher J. M. Scott, Robert Bartha, Sean Symons, Seyyed M. H. Haddad, Miracle Ozzoude, Nuwan Nanayakkara, Derek Beaton, Stephen Arnott, Dariush Dowlatshahi, Richard H. Swartz, Gustavo Saposnik, David Grimes, Anthony Lang, Corinne E. Fischer, Andrew Frank, Sanjeev Kumar, Bruce G. Pollock, David Tang-Wai, Elizabeth Finger, Jennifer S. Rabin, Walter Swardfager
Summary: Type 2 diabetes mellitus (T2DM) and hypertension are risk factors for cerebral small vessel disease (SVD), and their relationships with MRI-visible perivascular spaces (PVS) were investigated. T2DM patients had greater volumes of PVS in the white matter, and those with T2DM and hypertension had even greater volumes. Mediation models revealed indirect effects of T2DM on other SVD markers mediated by PVS in patients with hypertension. Understanding the regulation of cortical perivascular fluid dynamics may elucidate mechanisms linking T2DM to cerebral small vessel damage.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Maged Goubran, Brian David Mills, Marios Georgiadis, Mahta Karimpoor, Nicole Mouchawar, Sohrab Sami, Emily Larson Dennis, Carolyn Akers, Lex Mitchell, Brian Boldt, David Douglas, Phillip Scott Digiacomo, Jarrett Rosenberg, Gerald Grant, Max Wintermark, David Benjamin Camarillo, Michael Zeineh
Summary: This study investigated longitudinal changes in brain microstructure of high-contact (football) and low-contact (volleyball) collegiate athletes using advanced diffusion MRI. It found significant differences in microstructural metrics and tracts between football and volleyball players, especially in concussed football players. The findings suggest alterations in white matter development in football athletes due to concussive and repeated subconcussive impacts.
Article
Behavioral Sciences
Nathan W. Churchill, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Xiang Ji, Fuqiang Gao, Zhongmin Lin, Mario Masellis, Maged Goubran, Jennifer S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. Black, Bradley J. Macintosh, Simon J. Graham, Tom A. Schweizer
Summary: This study investigates the neurophysiological mechanisms underlying post-COVID headache, finding suppressed scaling properties in the brain activity of individuals with persistent headache compared to those without headache. This finding suggests a potential biomarker specific to post-COVID headache.
BRAIN AND BEHAVIOR
(2023)
Article
Engineering, Biomedical
Shuwei Xing, Joeana Cambranis Romero, Priyanka Roy, Derek W. Cool, David Tessier, Elvis C. S. Chen, Terry M. Peters, Aaron Fenster
Summary: This study proposes a 3D US-CT/MRI registration pipeline based on nnUNet vessel segmentation models. The effectiveness of the proposed approach is demonstrated through experiments on healthy volunteers and patient trials.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)