Article
Oncology
Paul R. Dominguez Gutierrez, Elizabeth P. Kwenda, William Donelan, Padraic O'Malley, Paul L. Crispen, Sergei Kusmartsev
Summary: This study identifies Hyal2-expressing tumor-associated myeloid cells of monocyte-macrophage lineage as contributors to hyaluronan degradation in bladder cancer tissue, leading to accumulation of inflammatory and proangiogenic low molecular weight hyaluronan fragments.
Review
Biochemistry & Molecular Biology
Qian Guo, Cuixia Yang, Feng Gao
Summary: CD44, a non-kinase transmembrane glycoprotein, interacts with its major ligand hyaluronan to trigger downstream signaling cascades that promote cellular behaviors such as proliferation and invasiveness. The activation state of CD44 varies in different tissues, but its role in tumor progression and CSC properties requires further investigation.
Article
Oncology
Weinan Li, Xiaoyu Zhang, Yang Nan, Li Jia, Jialin Sun, Lina Zhang, Yanhong Wang
Summary: The pH-responsive and CD44 receptor-mediated targeted nanoparticles loaded with Thioridazine showed great potential in eliminating cancer stem cells. In vitro release studies demonstrated effective drug release in acidic pH conditions. Cellular uptake studies confirmed efficient uptake of the nanoparticles in mammospheres, and in vivo distribution studies showed prolonged retention at tumor sites and improved tumor-suppressing effects.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Theodoros Karalis, Spyros S. Skandalis
Summary: Hyaluronan plays important roles in normal physiology and cancer, and its accumulation is associated with poor prognosis in cancer patients. Targeting the hyaluronan system may be a promising therapeutic strategy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Ting Xu, Lulu Han, Lingyun Jia
Summary: The selective mediation of cancer cell rolling is important for the high-throughput enrichment of high-speed cancer cells. A dense and stretched low molecular weight hyaluronic acid (HA) surface was constructed to promote the rolling of CD44-high cancer cells. This artificial biomaterial holds promise in enriching intact cells for downstream analysis in the clinics.
ACTA BIOMATERIALIA
(2022)
Article
Endocrinology & Metabolism
Mohamed Aboul Ezz, Alireza Mansouri, Ihshan Akthar, Mohamed Samy Yousef, Rasoul Kowsar, Akio Miyamoto
Summary: Recently, it was found that sperm induces the expression of CD44 and TLR2-mediated inflammation in the bovine uterus. This study aimed to investigate the effect of the interaction between CD44 and hyaluronan (HA) on sperm attachment and TLR2-mediated inflammation. In-silico approaches and in-vitro experiments using a sperm-BEECs co-culture model were conducted. The results showed a high affinity between CD44 and HA, and HA treatment increased sperm attachment and upregulated pro-inflammatory gene expression in BEECs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Alexandra N. Donlan, Tara E. Sutherland, Chelsea Marie, Saskia Preissner, Ben T. Bradley, Rebecca M. Carpenter, Jeffrey M. Sturek, Jennie Z. Ma, G. Brett Moreau, Jeffrey R. Donowitz, Gregory A. Buck, Myrna G. Serrano, Stacey L. Burgess, Mayuresh M. Abhyankar, Cameron Mura, Philip E. Bourne, Robert Preissner, Mary K. Young, Genevieve R. Lyons, Johanna J. Loomba, Sarah J. Ratcliffe, Melinda D. Poulter, Amy J. Mathers, Anthony Day, Barbara J. Mann, Judith E. Allen, William A. Petri
Summary: Research shows that elevated IL-13 levels are associated with severe COVID-19. In a mouse model, neutralizing IL-13 reduced disease severity and lung HA deposition. Administration of IL-13 induced HA in the lungs. Blocking the HA receptor CD44 prevented mortality, highlighting a potentially novel mechanism for IL-13-mediated HA synthesis in pulmonary pathology.
Review
Environmental Sciences
Jyoti Chandra, Nagashekhara Molugulu, Sivakumar Annadurai, Shadma Wahab, Ritu Karwasra, Surender Singh, Rahul Shukla, Prashant Kesharwani
Summary: Cancer is a complex disease that develops in response to a combination of hereditary and environmental risk factors, resulting in genomic changes. CD44, a transmembrane glycoprotein, serves as a potential biomarker and therapeutic target for cancer stem cells. Hyaluronic acid, a polysaccharide, shows affinity for the CD44 receptor, making it a promising candidate for selectively targeting CD44-positive cancer cells.
ENVIRONMENTAL RESEARCH
(2023)
Review
Oncology
Isis Wolf, Christian Gratzke, Philipp Wolf
Summary: Despite research and improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. Recent findings have highlighted the role of PC stem cells (PCSCs) in tumorigenesis, relapse, metastasis, and treatment resistance. This review discusses the impact of PCSCs in clinical practice and presents new therapeutic approaches to improve outcomes for PC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Environmental
Yuelong Niu, Jun Zhang, Jian Sun, Xinge Zhang, Zhongming Wu
Summary: The pathogenic bacteria-induced diabetic ulcer is a serious problem due to poor healing, but a non-antibiotic strategy utilizing a nanostructure with photothermal therapy shows promise in targeting and killing bacteria, promoting wound healing in diabetic rats.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Cell Biology
Michael Rose, Erik Noetzel, Jennifer Kistermann, Julian Eschenbruch, Sandra Rushrush, Lin Gan, Ruth Knuechel, Nadine T. Gaisa, Edgar Dahl
Summary: This study reveals that loss of ITIH5 in basal-type bladder cancer may inhibit cell growth and migration, and impact drug response via regulating the HA-CD44 axis.
Article
Chemistry, Applied
Junghan Lee, Enkhzaya Davaa, Yixin Jiang, Kyung-Ju Shin, Min Hye Kim, Hyunsu An, Jinho Kim, Su-Geun Yang, Steve K. Cho
Summary: In this study, we designed a photo-triggered reactive oxygen species (ROS)-generating nanoparticle and demonstrated its combined therapeutic effects against ovarian cancer. The study also identified a correlation between cancer stem cell markers and poor clinical outcomes in ovarian cancer patients, and showed that the nanoparticle could actively target these cancer stem cells. The experimental results indicated therapeutic effects of the nanoparticle both in vitro and in vivo, potentially overcoming the local therapeutic limitation of photodynamic therapy.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Ana M. Carvalho, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva
Summary: This study reveals the altered expression of hyaluronan (HA) receptors CD44 and RHAMM in the tumor microenvironment, which are associated with poor prognosis and treatment outcomes. The study also demonstrates the bi-directional communication between HA and breast cancer cell lines with different surface expression of CD44 and RHAMM. These findings are significant for the development of therapies targeting HA signaling in the tumor microenvironment.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Cornelia Tolg, Britney Jodi-Ann Messam, James Benjamin McCarthy, Andrew Cook Nelson, Eva Ann Turley
Summary: Signaling from actively remodeling extracellular matrix, particularly involving hyaluronan, plays a critical role in tissue repair and disease progression, such as metastatic cancer. This review discusses the multifunctional nature of hyaluronan and its receptors in wound healing, as well as the deregulation of HA metabolism in malignant progression and the potential for targeting HA in breast cancer management.
