Article
Medicine, General & Internal
Chul-Hyun Park, Kunwoo Kim, Jin-Tae Hwang, Jae-Hyung Choi, Yong-Taek Lee, Young Sook Park, Jung Ho Park, Kyung Jae Yoon
Summary: This study compared two methods of measuring upper esophageal sphincter (UES) relaxation and determined their diagnostic value in UES relaxation impairment. The results showed that VFSS and HRM have complementary ability in evaluating UES relaxation duration in patients with oropharyngeal dysphagia.
Review
Surgery
Pedro Norton, Fernando A. M. Herbella, Francisco Schlottmann, Marco G. Patti
Summary: This study reviewed the evaluation of the upper esophageal sphincter (UES) using high-resolution manometry (HRM) and found that HRM allows for more precise measurements compared to conventional manometry, but the clinical significance of these parameters still needs confirmation. Various diseases can affect UES function, including achalasia, gastroesophageal reflux disease, globus, neurologic diseases, and Zenker's diverticulum.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Otorhinolaryngology
Sophia M. Colevas, Lily N. Stalter, Corinne A. Jones, Timothy M. Mcculloch
Summary: This study describes the manometric representation of the resting upper esophageal sphincter (UES) using a clinically accessible method of measurement. The results demonstrate excellent within-subject reliability of the resting UES mean pressures and significant effects of age, number of sensors contained within the resting UES, and preceding swallow volume on mean resting UES pressure.
Article
Gastroenterology & Hepatology
Taher Omari, Charles Cock, Peter Wu, Michal Marcin Szczesniak, Mistyka Schar, Jan Tack, Nathalie Rommel
Summary: This study aimed to establish a methodology for diagnosing oropharyngeal disorders using P-HRM-I. The results showed that UES relaxation pressure was the best indicator for differentiating patients from controls and diagnosing UES disorders. A diagnostic scheme was also devised to identify patients with UES disorder or propulsive disorder. Additionally, the study found that patients with pharyngeal pressurizations and evidence of reduced UES relaxation and/or distensibility had higher aspiration scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Biophysics
Kechen Shu, James L. Coyle, Subashan Perera, Yassin Khalifa, Aliaa Sabry, Ervin Sejdic
Summary: This study aimed to investigate the correlation between high-resolution cervical auscultation (HRCA) signals and maximal upper esophageal sphincter (UES) opening measured from videofluoroscopy recordings. The results showed that HRCA signal features were significantly associated with the normalized anterior-posterior distension of UES opening, with a stronger correlation observed during the duration of UES opening.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Otorhinolaryngology
Katharina Winiker, Kristin Gozdzikowska, Esther Guiu Hernandez, Seh Ling Kwong, Phoebe Macrae, Maggie-Lee Huckabee
Summary: This study investigated the potential for behavioral modulation of resting pressure at the upper esophageal sphincter (UOS) in healthy adults. Participants were able to increase resting pressure after one week of training, but there was no evidence for purposeful pressure decrease. The capacity for purposeful pressure modulation was influenced by intensive biofeedback training, while healthy subjects may be limited by physiological factors.
Article
Otorhinolaryngology
Simone Miller, Martin Ptok, Michael Jungheim
Summary: This study investigated the UES reaction to different levels of acidity during swallowing, finding prolonged Restitution Times with stronger acid boluses. Significant differences were found towards neutral and less acidic boluses. Post-Swallow Maximum and Period of Sphincter Activity varied significantly, with higher values for the strongest acid bolus. Relaxation Times showed a slight trend of prolongation with higher bolus acidity, suggesting reflexive protective mechanisms triggered by receptors in the pharyngeal mucosa or UES.
Article
Otorhinolaryngology
Howell Henrian G. Bayona, Nicole Pizzorni, Jan Tack, Ann Goeleven, Taher Omari, Nathalie Rommel
Summary: This study demonstrates the diagnostic value of certain proposed and adjunct HRPM metrics for identifying signs of unsafe and inefficient bolus transport in patients with oropharyngeal dysphagia.
Article
Otorhinolaryngology
Kei Aoyama, Kenjiro Kunieda, Takashi Shigematsu, Tomohisa Ohno, Ichiro Fujishima
Summary: This study investigated the effect of different body positions on esophageal motility using high-resolution manometry. Results showed stronger esophageal contractions in the bridge position compared to upright, with shorter peristaltic breaks and longer distal latency. Further research is needed to examine the effectiveness of swallowing in the bridge position.
Article
Medicine, Research & Experimental
Seh Ling Kwong, Ester G. Hernandez, Katharina Winiker, Kristin Gozdzikowska, Phoebe Macrae, Maggie-Lee Huckabee
Summary: This study examined the effect of topical nasal anesthetic (TNA) on swallowing and tolerability during high-resolution impedance manometry (HRIM) with a 4.2-mm catheter. The results showed that TNA did not improve comfort or significantly affect swallowing behavior during the procedure.
Article
Medicine, Research & Experimental
Frederik J. Meisoll, Michael Jungheim, Jacob F. Fast, Simone Miller, Martin Ptok
Summary: The study found that when triggering the laryngeal adductor reflex, two distinct pressure phases of the upper esophageal sphincter were identified, labeled as P1 and P2. P1 phase may be a result of vocal fold activity causing changes in UES pressure, while the constriction during P2 phase could strengthen the barrier function of the UES in preparation to clear the airways.
Review
Food Science & Technology
Pengxu Wei
Summary: This article focuses on the treatment methods and effects of botulinum toxin injection for UES dysfunction. The research suggests that the entire UES should be targeted for injection rather than just the cricopharyngeal muscle. The article also discusses the therapeutic mechanisms of botulinum toxin and the strengths and weaknesses of guiding techniques.
Article
Gastroenterology & Hepatology
Sawangpong Jandee, Kasemsak Jandee
Summary: This study evaluated the diagnostic yield of high-resolution manometry in Thai patients, finding the highest yield in dysphagia patients. However, the test was not as beneficial in detecting clinically relevant esophageal motor disorders in patients presenting with non-dysphagia symptoms.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, Research & Experimental
Dustin Romain, Lauran K. Evans, Yvette Diaz, Kathryn Allen, Kristine Galek
Summary: This study presented a rare case of hypotonic upper esophageal sphincter (UES), with the patient able to achieve a more normal swallow pressure pattern using biofeedback and a specific maneuver during manometry. It also highlighted the importance of combining manometry with other swallow imaging techniques for effective treatment planning and patient outcomes.
Review
Otorhinolaryngology
Sebastian H. Doeltgen, Harsharan Kaur, Stephanie K. Daniels, Leila Mohammadi, Joanne Murray
Summary: The upper esophageal sphincter (UES) is crucial for safe swallowing, and there are various behavioral interventions available to improve UES opening. Different types of interventions have shown varying degrees of success in improving UES opening, with limited evidence base for their effectiveness.
Article
Medicine, Research & Experimental
Corinne A. Jones, Michelle R. Ciucci, Suzan M. Abdelhalim, Timothy M. McCulloch
Summary: This study measured swallowing pressure variability in healthy adults and found that it differed by pharyngeal region, bolus volume, and age, but not by sex. Abnormal swallowing pressure variability may indicate motor control deviations in individuals with swallowing impairment.
Article
Multidisciplinary Sciences
Tiffany J. Glass, Cynthia A. Kelm-Nelson, John C. Szot, Jacob M. Lake, Nadine P. Connor, Michelle R. Ciucci
Article
Audiology & Speech-Language Pathology
Sana Smaoui, Melanie Peladeau-Pigeon, Catriona M. Steele
Summary: This study investigated hyoid movement in healthy adults consuming liquids of various consistencies, finding stable measures across thin to extremely thick liquids without systematic alterations in movement or position.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Review
Neurosciences
Charles Lenell, Courtney K. Broadfoot, Nicole E. Schaen-Heacock, Michelle R. Ciucci
Summary: The rat model is a useful tool for studying communication and related deficits, as rat produce ultrasonic vocalizations (USVs) that are altered by various experimental conditions. Sex differences are apparent in both the rat larynx and USV acoustics, and are differentially affected by experimental conditions. Therefore, studying these sex differences across the lifespan can provide valuable insights into the effects of experimental conditions.
Article
Behavioral Sciences
Jesse D. Hoffmeister, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Vocal communication impairment and anxiety are common symptoms of Parkinson's Disease and both are influenced by the noradrenergic system. The study revealed significant relationships between vocal impairment, anxiety, and brainstem norepinephrine in a genetic rat model of PD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Audiology & Speech-Language Pathology
Jesse D. Hoffmeister, Christopher L. Ulmschneider, Corinne A. Jones, Michelle R. Ciucci, Timothy M. McCulloch
Summary: This study examined the feasibility of measuring phonatory air pressure at multiple locations in the lower vocal tract simultaneously using high-resolution pharyngeal manometry (HRM). The results showed that air pressures from different locations varied during vocal tract semi-occlusion tasks, with pressures increasing as the occlusion level increased. The high spatial and temporal resolution provided by HRM may be valuable for future studies investigating differences in lower vocal tract air pressures between normal and disordered populations.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Review
Neurosciences
Maryann N. Krasko, Jesse D. Hoffmeister, Nicole E. Schaen-Heacock, Jacob M. Welsch, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Parkinson's disease is a progressive disorder affecting 10 million people worldwide, with over 90% developing hypokinetic dysarthria. Limited understanding of pathological mechanisms and treatment options has led to exploration of rat models for insights into vocal deficits.
Article
Behavioral Sciences
Jesse D. Hoffmeister, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Vocal deficits and anxiety are common symptoms of Parkinson's Disease that have a significant impact on quality of life. Current dopamine replacement therapies are not effective in treating these symptoms, leading researchers to explore drug therapies targeting noradrenaline. The study showed that noradrenergic manipulation with certain drugs can decrease anxiety and modulate vocalization in a PD rat model.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Geriatrics & Gerontology
A. Kurosu, F. Osman, S. Daggett, R. Pena-Chavez, A. Thompson, S. M. Myers, P. VanKampen, S. S. Koenig, M. Ciucci, J. Mahoney, Nicole Rogus-Pulia
Summary: The study aimed to determine the prevalence of self-reported dysphagia in community-dwelling older adults receiving meal support and identify associated factors. Results showed approximately one in five community-dwelling older adults had self-reported dysphagia, with factors such as poor nutritional status, difficulty chewing, prior dysphagia and pneumonia diagnosis, and meal service site being associated with dysphagia.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Neurosciences
Denis Michael Rudisch, Maryann N. Krasko, Alex F. Nisbet, Nicole E. Schaen-Heacock, Michelle R. Ciucci
Summary: This paper reviews the important contributions of measuring tongue behaviors in awake rats and mice and discusses how these methods have been modified by other researchers to advance translational science.
BRAIN RESEARCH BULLETIN
(2022)
Review
Otorhinolaryngology
Rodolfo E. Pena-Chavez, Nicole E. Schaen-Heacock, Mary E. Hitchcock, Atsuko Kurosu, Ryo Suzuki, Richard W. Hartel, Michelle R. Ciucci, Nicole M. Rogus-Pulia
Summary: This study conducted a scoping review to examine the impact of food and liquid properties on swallowing physiology and function in adults. The findings revealed that various properties of food and liquids can modify the oral and pharyngeal phases of swallowing, including taste, odor, carbonation, viscosity, hardness, adhesiveness, and cohesiveness. These modifications also affect various measurements during swallowing, such as penetration/aspiration, oral transit time, lingual pressures, submental muscle contraction, oral and pharyngeal residue, hyoid and laryngeal movement, pharyngeal and upper esophageal sphincter pressures, and total swallow duration.
Article
Behavioral Sciences
Courtney K. Broadfoot, Charles Lenell, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Social isolation significantly affects vocalization and neurotransmitter levels in the VTA of rats.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Rehabilitation
Maryann N. Krasko, Denis Michael Rudisch, Ryan J. Burdick, Nicole E. Schaen-Heacock, Courtney K. Broadfoot, Alex F. Nisbet, Nicole Rogus-Pulia, Michelle R. Ciucci
Summary: This review summarizes current treatments for PD-associated dysphagia, including pharmacological, surgical, and behavioral interventions, as well as the contributions of translational animal research. Current interventions targeting dopamine dysfunction have limited effects, and behavioral interventions are most effective for dysphagia treatment. Animal research has advanced our understanding of PD and dysphagia mechanisms and shows promise for studying treatment options.
CURRENT PHYSICAL MEDICINE AND REHABILITATION REPORTS
(2023)
Article
Rehabilitation
Denis Michael Rudisch, Maryann N. N. Krasko, Ryan Burdick, Courtney K. K. Broadfoot, Nicole Rogus-Pulia, Michelle R. R. Ciucci
Summary: The majority of individuals with Parkinson disease (PD) experience dysphagia, which is often diagnosed late in the disease progression. This review provides an overview of the current understanding of PD pathophysiology and discusses the diagnostic practices, knowledge gaps, and future directions in dysphagia research.
CURRENT PHYSICAL MEDICINE AND REHABILITATION REPORTS
(2023)
Letter
Clinical Neurology
Cynthia A. Kelm-Nelson, Sarah A. Lechner, Samantha E. Lettenberger, Taylor A. R. Kaldenberg, Natalie K. Pahapill, Amy Regenbaum, Michelle R. Ciucci
BRAIN COMMUNICATIONS
(2021)