Article
Pharmacology & Pharmacy
Ruxue Huang, Lulu Ding, Ying Ye, Ke Wang, Wenjing Yu, Bingzhao Yan, Zongping Liu, Jicang Wang
Summary: Cadmium induces kidney injury and apoptosis, while Quercetin reduces kidney damage caused by Cadmium by decreasing oxidative stress and inhibiting apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chikage Mori, Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh
Summary: Cadmium, a toxic heavy metal widely present in the environment, causes renal proximal tubule disorder in chronic poisoning. This study reveals that PPAR delta plays a critical role in modifying susceptibility to Cd renal toxicity, possibly through the apoptosis pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaomin Li, Ting Chen, Xiaofen Wu, Xiao Jiang, Peng Luo, E. Zixuan, Chaoqun Hu, Chunhua Ren
Summary: Apoptosis is a critical biological process for embryonic development, tissue differentiation, and organism homeostasis. A novel apoptosis-inducing factor called AIF-2 has been identified in sea cucumbers, and it is involved in heavy metal-induced apoptosis, contributing to the understanding of the caspase-independent apoptotic pathway in ancient echinoderm species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Caiying Zhang, Xueru Wang, Gaohui Nie, Zejing Wei, Shaoxing Pi, Chang Wang, Fan Yang, Ruiming Hu, Chenghong Xing, Guoliang Hu
Summary: The experiment results suggest that molybdenum and cadmium may induce oxidative stress and pyroptosis in duck kidneys, with a more significant impact when combined.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Ling Ou, Haixia Wang, Zhidi Wu, Panpan Wang, Li Yang, Xiaoyun Li, Kehuan Sun, Xiaofeng Zhu, Ronghua Zhang
Summary: Cadmium toxicity on bone involves factors such as reduced cell viability, inhibition of osteoblast-related proteins, decreased alkaline phosphatase activity, DNA damage induction, and promotion of apoptosis. Mechanisms include Exportin-1 accumulation, JNK phosphorylation, and activation of Caspase-dependent pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Zhuanxu Ouyang, Bijing Yang, Jiangnan Yi, Shanshan Zhu, Suge Lu, Yingwei Liu, Yangwei Li, Yuanliang Li, Khalid Mehmood, Riaz Hussain, Muhammad Ijaz, Jianying Guo, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: This study revealed the harmful effects of sodium fluoride on liver tissues of ducks, including promoting apoptosis and altering the expression levels of key genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Jiabin Chen, Weina Lai, Yaotang Deng, Min Liu, Ming Dong, Zhidong Liu, Ting Wang, Xiang Li, Zhiqiang Zhao, Xiao Yin, Jinmei Yang, Rian Yu, Lili Liu
Summary: This study investigated the role of miR-363-3p in Cd-induced nephrotoxicity in occupational workers. The findings suggest that the increase of miR-363-3p is associated with down-regulation of PI3K and suppressed proliferation and enhanced apoptosis of renal tubule epithelial cells. MiR-363-3p may be considered for possible therapeutic strategies for Cd-associated kidney damage.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Francesca Anson, Pintu Kanjilal, S. Thayumanavan, Jeanne A. Hardy
Summary: Cytosolic protein delivery shows promise in various applications. However, the use of fluorescent tags can lead to undesired consequences which are often overlooked, making distinguishing between cytosolically released and endosomally entrapped proteins challenging. The development of a caspase-3 variant tagged with GFP aims to address this issue and facilitate the study of therapeutic properties and apoptotic cell death mechanisms.
Article
Biology
Kanglei Zhang, Wenxuan Dong, Jiahui Li, Zhonggui Gong, Wenjing Liu, Shuangjiang He, Hui Zou, Ruilong Song, Gang Liu, Zongping Liu
Summary: This study investigated the effects of Cadmium (Cd) on quail kidney injury and the protective effect of Honokiol (HKL) on Cd-induced nephrotoxicity. The results showed that Cd caused significant changes in growth performance, kidney histopathology, antioxidant enzymes, and other parameters, while HKL treatment alleviated oxidative stress and improved kidney function.
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Rania A. Abdel-Emam, Marwa F. Ali
Summary: This study aimed to investigate the hepatoprotective effect of L-carnitine against lead acetate-induced hepatocellular injury and its underlying mechanisms. The results showed that L-carnitine effectively reduced liver enzymes' levels and improved oxidative and inflammatory markers. The phosphorylation of glycogen synthase kinase-3 beta was enhanced by L-carnitine, while lead acetate treatment reduced its phosphorylation. Histopathological examination revealed that L-carnitine decreased hepatic damage and inflammation. Overall, L-carnitine displayed significant protective effects against hepatocellular apoptosis and inflammation induced by lead acetate.
Article
Biochemistry & Molecular Biology
Jiaming Zheng, Guobin Qiu, Yewen Zhou, Kezhe Ma, Sheng Cui
Summary: The study evaluated the ameliorative function of Taurine against Cadmium-induced liver toxicity in mice. Results showed that Taurine can alleviate liver cell damage induced by Cadmium and has anti-inflammatory and anti-apoptotic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Cell Biology
Lujia Feng, Yantao Wei, Yimeng Sun, Linbin Zhou, Shaowei Bi, Weirong Chen, Wu Xiang
Summary: Cataracts are a leading cause of blindness worldwide, with age being a major risk factor. The exact mechanisms of cataractogenesis are still unclear. A recent study found that microRNA-34a (MIR34A) is involved in cataract development, but the underlying pathogenesis is unknown. This study showed that hexokinase 1 (HK1) is a target gene of MIR34A and demonstrated that MIR34A modulates lens epithelial cell apoptosis and cataract development through the HK1/caspase 3 signaling pathway.
Review
Biochemistry & Molecular Biology
Merve Nur Ceylan, Sevginur Akdas, Nuray Yazihan
Summary: The study found that serum zinc level and dietary zinc intake may play a crucial role in preventing osteoporosis, while zinc supplementation may help improve bone turnover markers for bone formation (such as serum osteocalcin and serum alkaline phosphatase) and bone mineral density at the femoral neck site.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Ophthalmology
Gokhan Koca, Evin Singar, Aylin Akbulut, Nuray Yazihan, Nihat Yumusak, Ayten Demir, Meliha Korkmaz
Summary: The study showed that resveratrol (RSV) has radioprotective, antioxidant, and anti-apoptotic effects on lacrimal gland damage caused by high-dose radioactive iodine therapy. The findings suggest that RSV could protect the lacrimal glands from inflammation and cellular damage induced by RAI treatment.
CURRENT EYE RESEARCH
(2021)
Article
Pathology
Ozge Yucel Celik, Sevginur Akdas, Aykan Yucel, Burcu Kesikli, Nuray Yazihan, Dilek Uygur
Summary: The study found that placental zinc concentrations and the placental zinc/copper ratio were significantly lower in pregnancies with IUGR, suggesting a potential association between placental zinc and zinc/copper status and IUGR.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Pathology
Hasan Eroglu, Mehmet Akif Erdol, Nazan Vanli Tonyali, Gokcen Orgul, Derya Biriken, Aykan Yucel, Nuray Yazihan, Dilek Sahin
Summary: The study compared proBNP levels in maternal serum and fetal cord blood between healthy pregnancies and those with intrauterine growth restriction (IUGR). It was found that proBNP levels were significantly higher in newborn cord blood with IUGR compared to the control group, but there was no significant difference in maternal serum proBNP levels between women with IUGR and healthy controls.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Metin Yalaza, Irem Akin, Seda Altiner, Pelin Aribal Ayral, Nuray Yazihan
Summary: The study demonstrated that carnosine has beneficial effects on improving lung injury by reducing oxidative stress, proinflammatory cytokines, and apoptosis. Further investigations are needed to elucidate which mechanism is more effective to cure lung damage in humans.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Ophthalmology
H. Atilgan, A. Akbulut, N. Yazihan, N. Yumusak, E. Singar, G. Koca, M. Korkmaz
Summary: This study evaluated the radioprotective effect of spirulina on the lacrimal glands after RAI treatment, and the results showed that spirulina can protect the lacrimal glands from RAI-induced damage.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Review
Medicine, Research & Experimental
Irem Akin, Sevginur Akdas, Merve Nur Ceylan, Seda Altiner, Pelin Aribal Ayral, Nuray Yazihan
Summary: This study demonstrated that AdvaxTM, derived from delta inulin, is a safe and well-tolerated adjuvant capable of enhancing the immunogenicity and protection of vaccines without safety concerns. Further research is required to confirm the effects of AdvaxTM in different vaccine formulations.
ADVANCES IN MEDICAL SCIENCES
(2022)
Article
Veterinary Sciences
Sibel Isin, Nuray Yazihan, Burcu Kesikli, Derya Biriken, Sevginur Akdas, Ferda Topal Celikkan, Batuhan Bakirarar, Pelin Aribal Ayral
Summary: This study aimed to evaluate the effects of dose-dependent ascorbic acid (AA) administration on the repair process after gastrocnemius muscle injury in rats. It was found that a dose of 5 mg/kg/day AA administration reduced serum IL-6 and muscle tissue TNF-alpha levels, and increased liver tissue IL-10 levels. Muscle tissue collagen levels were not statistically different between the groups.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2023)
Article
Endocrinology & Metabolism
Deniz Oluklu, Dilek Menekse Beser, Derya Uyan Hendem, Selcan Sinaci, Ezgi Turgut, Nuray Yazihan, Dilek Sahin
Summary: This study compared the serum midkine levels in pregnant women with different types of diabetes mellitus and healthy pregnant women. The results showed that the serum midkine levels were higher in pregnant women with diabetes mellitus compared to healthy pregnant women. However, serum midkine levels were not able to predict adverse neonatal outcomes in the diabetic group.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joachim Greilberger, Ralf Herwig, Mehtap Kacar, Naime Brajshori, Georg Feigl, Philipp Stiegler, Reinhold Wintersteiger
Summary: The study showed that aKG and 5-HMF have significant effects on apoptosis and cell proliferation of Jurkat cell line, with 5-HMF demonstrating better inhibitory effects on cell growth and mitochondrial activity compared to aKG. The combination of both substances synergistically showed the highest effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ralf Herwig, Katharina Erlbacher, Amela Ibrahimagic, Mehtap Kacar, Naime Brajshori, Petrit Beqiri, Joachim Greilberger
Summary: The study demonstrated that the water-soluble vitamin D dimeric compound VitD-dgVDBP promotes macrophage activity while reducing O-2(-) production, and has positive effects on cell apoptosis and immune pathways such as CD16.
Article
Biology
Hajer Mohamed Hmmam, Muhsine Sinem Ethemoglu, Meltem Yalcin, Cihan Suleyman Erdogan, Bayram Yilmaz, Mehtap Kacar
Summary: This study investigated the effects of fluoxetine on airway smooth muscles (ASMs) using an isolated organ bath system. The results showed that fluoxetine had no contractile effect on ASMs in the isolated organ bath system. Future studies are needed to evaluate the effects of oral usage of fluoxetine on bronchial muscle in different experimental models, in order to explain the adverse/beneficial effects of fluoxetine in subjects with respiratory conditions.
Article
Obstetrics & Gynecology
Bedri Sakcak, Ezgi Turgut, Ramazan Denizli, Nihat Farisogullari, Atakan Tanacan, Nuray Yazihan, Dilek Sahin
Summary: This study aimed to evaluate changes in maternal serum midkine levels in pre-eclampsia. The study included 40 pregnant women with pre-eclampsia and 66 healthy pregnant women in the control group. The results showed that the midkine level was significantly higher in pregnant women with pre-eclampsia compared to the controls. Midkine may be associated with complicated inflammatory processes leading to pre-eclampsia, and further research is needed to investigate its role as a novel marker for prediction of pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Food Science & Technology
Irem Uzunsoy, Sebnem Ozturkoglu Budak, Tuba Sanli, Birce Taban, Aykut Aytac, Nuray Yazihan, Ahmet Levent Bas, Barbaros Ozer
Summary: The present study investigated the suitability of combinations of Streptococcus thermophilus and five Lactobacillus delbrueckii subsp. bulgaricus isolates for industrial yogurt productions. The fermentation profiles of the combinations were analyzed, and the physical, chemical, and sensory characteristics of the yogurt samples were monitored during storage. The results showed that all the combinations were suitable for commercial yogurt productions, with similar gelation profiles and shear-thinning non-Newtonian flow behavior.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2023)
Article
Virology
Nuray Yazihan, Atakan Tanacan, Seyit A. Erol, Ali T. Anuk, Selcan Sinaci, Derya Biriken, Huseyin L. Keskin, Ozlem T. Moraloglu, Dilek Sahin
Summary: The study compared VEGF-A values between pregnant women with COVID-19 and healthy controls, as well as their association with inflammation parameters, disease severity, and obstetric complications. The results showed similar serum VEGF-A levels between the two groups, but a higher rate of obstetric complications in the COVID-19 group.
JOURNAL OF MEDICAL VIROLOGY
(2021)
