Review
Toxicology
Frank Thevenod, Timm Schreiber, Wing-Kee Lee
Summary: The kidney plays a crucial role in sensing changes in systemic oxygen tension and detoxification of transition metals. This review explores the molecular mechanisms of how these metals interact with the oxygen sensing pathway in the kidney and their implications in renal physiology, pathophysiology, and toxicology.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Hana Caloudova, Jana Blahova, Jan Mares, Lukas Richtera, Ales Franc, Michaela Garajova, Frantisek Tichy, Jiri Lenz, Jana Caloudova, Vladimira Enevova, Pavel Kopel, Barbora Havelkova, Pavla Lakdawala, Zdenka Svobodova
Summary: In this study, the subchronic effects of Magneli phase titanium suboxides (Magneli TiOx) were evaluated and compared with TiO2 particles. It was found that Magneli TiOx had fewer adverse effects on fish compared to TiO2, and exhibited good antioxidant stress resistance.
Review
Plant Sciences
Anmol Gupta, Priya Dubey, Manoj Kumar, Aditi Roy, Deeksha Sharma, Mohammad Mustufa Khan, Atal Bihari Bajpai, Ravi Prakash Shukla, Neelam Pathak, Mirza Hasanuzzaman
Summary: Arsenic contamination is a severe problem with toxic effects on the environment and human health. Mycoremediation approaches, using specific fungi, have potential for reducing arsenic levels and mitigating its detrimental effects. This review explores the relationship between arsenic exposure, oxidative stress, and signaling pathways, and discusses the mechanisms involved in mycoremediation.
Article
Environmental Sciences
Ana Claudia F. Souza, Daniel S. S. Bastos, Felipe Couto-Santos, Luiz Otavio Guimaraes-Ervilha, Larissa S. Araujo, Pedro H. C. A. Souza, John L. P. Coimbra, Leandro L. Oliveira, Simone E. F. Guimaraes, Mariana Machado-Neves
Summary: This study investigated the long-term effects of prenatal arsenic exposure on reproductive parameters of male offspring at peripubertal and adult periods. Results revealed that arsenic exposure affected body and reproductive organ weights, as well as testicular and epididymal morphology in peripubertal animals but recovered in adulthood. Antioxidant gene expression and the endogenous antioxidant system in the testes and epididymides were affected by arsenic exposure in both peripubertal and adult rats. Impairment in daily sperm production and sperm parameters was observed in adult animals. Therefore, prenatal arsenic exposure has a long-term impact on reproductive parameters and may affect fertility potential in adult animals through oxidative stress.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Medicine, Research & Experimental
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
Summary: This review aims to provide a comprehensive collection of potential cytoprotective remedies in overcoming nephrotoxicity caused by anti-neoplastic drug metabolism and renal oxidative stress. There is an increasing need for renal replacement therapy and higher mortality rates from end-stage renal disease in the next decade, making the discussion of 43 different cytoprotective compounds crucial.
Article
Engineering, Environmental
Patricia Carneiro, Raquel Vieira, Carlos Venancio, Luis Felix
Summary: This study evaluated the effects of acute exposure to menthol on zebrafish embryos and found that it led to decreased hatching rate, heart rate, and increased malformations and mortality. At the molecular level, menthol exposure increased reactive oxygen species and antioxidant enzyme activity, as well as altered energy metabolism and mitochondrial function. At the behavioral level, menthol-treated larvae exhibited anxiety-like behavior. Additionally, there were decreases in dopaminergic neurons and acetylcholinesterase activity, indicating neuro-behavioral impairment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Environmental Sciences
Jinze Ma, Ping Jiang, Yong Huang, Chen Lu, Guiyou Tian, Xiaoping Xiao, Yunlong Meng, Xiaoqiang Xiong, Bo Cheng, Di Wang, Huiqiang Lu
Summary: The herbicide flumioxazin has been found to induce cardiac defects in vertebrates, possibly due to oxidative stress. This study investigated the underlying mechanisms and found that flumioxazin caused cardiac malformations and abnormal gene expression associated with cardiac development. It also led to increased oxidative stress and apoptosis in the zebrafish heart. The antioxidant astaxanthin reversed these effects and protected against flumioxazin-induced cardiotoxicity.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Guangrong Xie, Qipeng Zhang, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, Xuemei Jiang, Jian Li, Mengmeng Sun, Yuanfeng Zou, Chao Huang, Lixia Li, De Wu, Bin Feng
Summary: This study found that excessive intake of oxidized fat during pregnancy and lactation can harm both the mother's body and the health of their offspring. However, supplementation of vitamin D and inulin during pregnancy and lactation can mitigate these damages.
Article
Biochemistry & Molecular Biology
Srividya Ganapathy, Elisa R. Farrell, Simran Vaghela, Lucy Joshee, Earl G. Ford, Olga Uchakina, Robert J. McKallip, Jennifer L. Barkin, Christy C. Bridges
Summary: This study assessed the transport of MeHg into placental syncytiotrophoblasts and characterized the mechanisms by which it exerts toxic effects. MeHg compounds were found to be transported into cells primarily by sodium-independent amino acid carriers and organic anion transporters. MeHg altered mitochondrial function and viability, decreased mitophagy and autophagy, and increased oxidative stress. Exposure to higher concentrations of MeHg inhibited the ability of cells to protect against MeHg-induced injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Naseh Abdollahzade, Shirin Babri, Maryam Majidinia
Summary: Prenatal exposure to arsenic increases the risk of brain damage in the fetus, while melatonin shows neuroprotective effects by reducing oxidative stress and inflammation caused by arsenic, as well as suppressing DNA damage and apoptosis in the brain tissues of offspring rats.
Article
Engineering, Environmental
Hamada AbdElgawad, Gaurav Zinta, Walid Abuelsoud, Yasser M. Hassan, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Rafat Zrieq, Gerrit T. S. Beemster, Sebastjen Schoenaers
Summary: Utilizing a strain of Nocardiopsis lucentensis S5 can reduce arsenic uptake and toxicity in barley and maize plants. This strain also stimulates plant detoxification capacity, promotes biomass gain, and aids in plant growth recovery on arsenate polluted soils.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Fei Xu, Peng Chen, Hao Li, Suyu Qiao, Jiaxin Wang, Ying Wang, Xitong Wang, Bohan Wu, Huangkang Liu, Can Wang, Heng Xu
Summary: Through comparative transcriptome analysis, differences in the response of Pleurotus ostreatus and Pleurotus cornucopiae to Cd contamination were identified, including differences in Cd accumulation, removal rates, and expression of differentially expressed genes. Functional categories and pathways involved in Cd detoxification also differed between the two species, providing new insights into the molecular mechanisms of mycoremediation and accumulator screening.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
S. M. L. Lavarias, K. D. Colpo, S. M. Landro, E. S. Ambrosio, A. Rodrigues Capitulo, F. Arrighetti
Summary: The study evaluated the acute effects of two pesticides on prawns, finding that lipid peroxidation and protein oxidation levels were affected at the lowest concentrations. Additionally, histopathological damage was observed in a dose-dependent manner.
Article
Environmental Sciences
Leila Lemos, Laura Gantiva, Catherine Kaylor, Alessandra Sanchez, Natalia Quinete
Summary: This study assessed the exposure of per- and polyfluoroalkyl substances (PFAS) and phthalate esters (PAEs) in American oysters collected from three study sites in Florida. The results showed that all tested PFAS and PAEs compounds were detected in at least one oyster at each site. The oysters from Biscayne Bay exhibited the highest concentrations of PFAS and PAEs, while the oysters from Marco Island displayed the highest levels of lipid peroxidation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Koser Bano, Bharty Kumar, Mohammed Nasser Alyemeni, Parvaiz Ahmad
Summary: In this study, the use of salicylic acid (SA) was found to reduce the toxicity of arsenic (As) and enhance the antioxidant capacity of Brassica napus plants, leading to improved growth and photosynthesis. A concentration of 500 mM SA was most effective in mitigating the adverse effects of As.
Article
Environmental Sciences
Lianthuamluaia Lianthuamluaia, Puthiyottil Mishal, Debabrata Panda, Uttam Kumar Sarkar, Vikash Kumar, Kavitha Mandhir Sandhya, Gunjan Karnatak, Suman Kumari, Asit Kumar Bera, Subrata Das, Yusuf Ali
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Chemistry, Medicinal
Arun Kumar De, Ramachandran Muthiyan, Samiran Mondal, Nilkamal Mahanta, Debasis Bhattacharya, Perumal Ponraj, Kangayan Muniswamy, Anandamoy Kundu, Madhu Sudhan Kundu, Jai Sunder, Dhanasekar Karunakaran, Asit Kumar Bera, Sibnarayan Dam Roy, Dhruba Malakar
Article
Microbiology
Tanmoy Rana
Article
Agriculture, Dairy & Animal Science
Arun Kumar De, Sneha Sawhney, Samiran Mondal, Perumal Ponraj, Sanjay Kumar Ravi, Gopal Sarkar, Santanu Banik, Dhruba Malakar, Kangayan Muniswamy, Ashish Kumar, Arvind Kumar Tripathi, Asit Kumar Bera, Debasis Bhattacharya
Article
Fisheries
A. K. Bera, B. K. Das, D. Mohanty, N. Chakraborty, S. Dey, R. C. Malick, R. K. Manna, P. Majhi, Lianthuamluaia, T. Tayung, H. S. Swain, A. K. Sahoo, H. Chowdhury, U. K. Sarkar
Summary: This study investigated a mass mortality of fishes in a small tropical reservoir in Odisha, India, potentially caused by environmental factors and diseases. In experimental challenges, isolated bacteria showed pathogenicity in respective hosts, similar to the situation in the reservoir.
Article
Environmental Sciences
Nilemesh Das, Raju Baitha, Ashok Kumar, Rajisha Ravindran, Nanitha Krishna, Sanjib Kumar Manna, Dhruba Jyoti Sarkar, Asit Kumar Bera, Subir Kumar Nag, Basanta Kumar Das, Prasanna Kumar Patil
Summary: This study investigated the pharmacokinetics and withdrawal period of oxytetracycline (OTC) in intensively cultured catfish. The findings revealed low bioavailability and low blood concentration after oral administration, indicating that in-feed administration of OTC may not be effective for controlling bacterial diseases in catfish.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tanmoy Rana
Summary: Selenium nanoparticles (Se-NPs) have regulatory effects on growth performance, antioxidant defense, and antimicrobial activity in poultry research, playing a crucial role in modulating intestinal health through the maintenance of beneficial microflora and production of short-chain fatty acids.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Tanmoy Rana
Summary: This review examines the role and mechanisms of nitric oxide (NO) in inflammatory bowel disease (IBD) and its impact on dogs. The accelerated production of NO may lead to intestinal inflammation and cell damage. NO plays a crucial role in modulating epithelial permeability and immune response, but excessive production can have adverse effects on mucosal cells. Chronic inflammation and nitric oxide play key roles in gastrointestinal carcinogenesis.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Immunology
V. Kumar, B. K. Das, H. S. Swain, H. Chowdhury, S. Roy, A. K. Bera, R. Das, S. N. Parida, S. Dhar, A. K. Jana, B. K. Behera
Summary: Temperature plays a role in the susceptibility of freshwater fishes to parasitic infections, such as Ichthyophthirius multifiliis, which causes white spot disease. In this study, the researchers investigated the mechanism of co-infection between the parasite and the bacteria Aeromonas hydrophila in Pangasianodon hypophthalmus. They found that supplementation with turmeric oil improved the fish's immune response and increased survival against co-infection. The use of turmeric oil in aquaculture may be a promising strategy to control co-infections in fishes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Arun Kumar De, Sneha Sawhney, Ramachandran Muthiyan, Debasis Bhattacharya, Perumal Ponraj, Dhruba Malakar, Jai Sunder, T. Sujatha, Ashish Kumar, Samiran Mondal, Asit Kumar Bera, P. A. Bala, Eaknath B. Chakurkar
Summary: This study investigates the genetic diversity and population structure of Andaman cattle, a precious indigenous species in India, and examines its evolution in relation to zebu domestication and the Island Southeast Asia. The findings show that Andaman cattle has high genetic diversity and the potential to withstand climate change. The study also reveals a close genetic affinity between Andaman cattle, cattle from the Indian subcontinent, and those from Island Southeast Asia, indicating multidirectional gene flow and cultural/trade relationships.
Article
Microbiology
Vikash Kumar, Basanta Kumar Das, Himanshu Sekhar Swain, Hemanta Chowdhury, Suvra Roy, Asit Kumar Bera, Ramesh Chandra Malick, Bijay Kumar Behera
Summary: The study found that an extract from Eclipta alba leaves, at concentrations between 50-100 ppm, can protect Heteropneustes fossilis fingerlings against Aphanomyces invadans infection. The extract induces anti-stress and antioxidative response in fish, enhancing their survival and immunity against the pathogen. This study suggests that the extract could be used as part of a holistic strategy to control epizootic ulcerative syndrome (EUS) in fish species.
Article
Biology
Nabanita Chakraborty, Basanta Kumar Das, Asit Kumar Bera, Simanku Borah, Debasmita Mohanty, Anil Kumar Yadav, Jeetendra Kumar, Satish Kumar Koushlesh, Thangjam Nirupada Chanu, Soumya Prasad Panda, Ravali Vallangi
Summary: This study aims to investigate the virulence genes and antibiotic resistance of Aeromonas strains in fish, and the results suggest that these strains pose a potential threat to aquaculture and may transfer antibiotic resistance to human pathogens.
Article
Genetics & Heredity
Arun Kumar De, Sneha Sawhney, Jai Sunder, Ramachandran Muthiyan, Perumal Ponraj, Tamilvanan Sujatha, Dhruba Malakar, Samiran Mondal, Asit Kumar Bera, Ashish Kumar, Eaknath Bhanudasrao Chakurkar, Debasis Bhattacharya
Summary: Andaman and Nicobar Islands in Southeast Asia have native breeds of livestock and poultry, including Andaman local goat and Teressa goat. However, their origin and genetic makeup have not been fully studied. This study analyzed the mitochondrial D-loop sequence of Andaman goats to investigate their genetic diversity, phylogeographical signaling, and population expansion events. The Teressa goat showed lower genetic diversity compared to the Andaman local goat. The majority of haplotypes in Andaman goats belonged to haplogroup A, with some belonging to haplogroup B and D. Based on the poor geographical signaling, it is hypothesized that Andaman goats have been imported to the islands through multidirectional or unidirectional diffusion. Importantly, the possibility of unidirectional diffusion from the Indian subcontinent via maritime routes cannot be ignored.
Article
Veterinary Sciences
Perumal Ponraj, Arun Kumar De, Samiran Mondal, Sanjay Kumar Ravi, Sneha Sawhney, Gopal Sarkar, Asit Kumar Bera, Dhruba Malakar, Ashish Kumar, Laishram Brojendra Singh, Sheikh Zamir Ahmed, Kangayan Muniswamy, Bosco Augustine Jerard, Debasis Bhattacharya
Summary: This study successfully treated Stephanofilariasis in cattle using an FDA-approved drug and herbal preparation. The tri-model therapy significantly reduced lesions within 30 days of treatment and has the potential to cure humpsore.
VETERINARY SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Subhashree Das, A. K. De, P. Perumal, A. K. Bera, T. Rana, K. Muniswamy, A. Kundu, R. Muthiyan, D. Malakar, D. Bhattacharya, P. Das, S. Samanta, D. Pan
INDIAN JOURNAL OF ANIMAL SCIENCES
(2020)
